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Coenzyme A for injection and production process thereof

A technology for injection and water for injection, which is applied in the field of preparation of coenzyme A freeze-dried powder injection, which can solve the problems of low production efficiency and long freezing time, and achieve the effects of improving production efficiency, full appearance and clear solution

Inactive Publication Date: 2012-04-04
HENAN FUREN HUAIQINGTANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, in the prior art, the freezing time is long and the production efficiency is low

Method used

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Embodiment Construction

[0019] Coenzyme A for injection of the present invention is composed of coenzyme A, mannitol, dextran, calcium gluconate, sodium bisulfite, medicinal charcoal, and fresh water for injection; wherein, every 1000ml of coenzyme A for injection contains 100,000 units of coenzyme A , 32g mannitol, 16g dextran, 4g calcium gluconate, 3g sodium bisulfite and 3g medicinal charcoal, and the rest are fresh water for injection.

[0020] The production process of the present invention is as follows: unscrambling→washing, drying and extinguishing→washing, extinguishing and corking→preparation→filling→freeze-drying→capping→light inspection→packing→storage.

[0021] 1. Washing, drying, and sterilizing bottles: Put the sorted vials into the bottle washing machine, rough wash with water for injection, wash with three gases and three water, and sterilize in a tunnel oven. Its control parameters: compressed air pressure: 0.30-0.45Mpa, injection water pressure ≥ 0.35Mpa, water temperature: 60°C-80...

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Abstract

The invention provides a coenzyme A for injection and a production process thereof. The coenzyme A for injection consists of a coenzyme A, mannitol, dextran-40, calcium gluconate, sodium bisulfite, medicinal charcoal and fresh water for injection. The production process comprises the following steps of: adding the dextran-40, mannitol and calcium gluconate into the water for injection for dissolving, adding the medicinal charcoal, and cooking to boiling state; filtering and decarburizing the solution with a titanium stick, and filtering; mixing a sodium bisulfite aqueous solution with the filtered and decarburized solution, regulating the pH value with hydrochloric acid, replenishing the water for injection for preparing, and filtering with a microporous filtering film to obtain a coenzyme A solution for injection; and pre-freezing the coenzyme A solution for injection, subliming and drying to obtain a coenzyme A freeze-dried powder injection. In a preparation method, a freeze drying process is improved, the freeze drying time is shortened, and the production efficiency is increased greatly. The obtained freeze-dried powder injection has plump appearance, a clarified solution and high product content stability, and is quickly dissolved in water.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a preparation method of coenzyme A freeze-dried powder injection. Background technique [0002] Coenzyme A is a coenzyme for acetylation reactions in the body. Participate in the acetylation reaction in the body and play an important role in the metabolism of sugar, fat and protein, such as tricarboxylic acid cycle, liver glycogen accumulation, acetylcholine synthesis, lowering cholesterol, regulating blood lipid content and synthesizing steroid substances, etc. This product is closely related. [0003] Coenzyme A injection is used for adjuvant treatment of leukopenia, idiopathic thrombocytopenic purpura and functional low fever. Because it is unstable to heat, the potency is easy to decrease, and the active ingredients of the drug are easily adsorbed by activated carbon. Therefore, problems such as poor drug content stability, poor color grade, and high reject rate o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/7076A61K47/36A61P7/00A61P7/04A61P3/00
Inventor 朱永杰陈水库白宗锋
Owner HENAN FUREN HUAIQINGTANG PHARMA
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