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Dioscorea nipponica Makino saponin extraction method

An extraction method, the technology of Dioscorea chinensis, applied in the field of medicinal chemistry, can solve the problems of increasing product cost, long extraction time, solvent consumption, etc., and achieve the effects of saving production cost, short extraction time, and reducing consumption

Active Publication Date: 2012-03-28
JILIN HONGJIU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the extraction of Dioscorea saponins by using the heat reflux extraction method is only to extract the saponins in Dioscorea chinensis through leaching, and the extraction times are many, the extraction time is long, and the extraction rate is low.
Moreover, hot reflux extraction requires continuous heating, which will cause a large amount of volatilization loss of ethanol during the heating reflux process, and a large amount of ethanol solvent will remain in the extracted medicinal residues, resulting in a large amount of solvent consumption and increasing product costs.
In addition, heat reflux extraction requires steam heating, so a large amount of thermal energy is consumed, and environmental problems such as exhaust gas and dense smoke are generated, which pose a certain burden on environmental protection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 100g of 2-3mm coarse particles of Dioscorea chinensis, put it into a medicinal vacuum composite bag, add 8 times the amount of 95% ethanol, seal it, soak it for 4 hours, put it in the liner of the ultra-high pressure extraction equipment, start the electric heating, and put the The temperature rises to 60°C, within 5 minutes, the pressure rises to 500MPa, maintains for about 10 minutes, and then instantly reduces the pressure to zero within 2 seconds. Collect the ultra-high pressure extract, filter the extract, and reserve the filtrate for later use. Put the residual medicinal residues into a filter bag, centrifuge at 3000r / min for 15min, collect the centrifuged supernatant and combine with the filtrate, recover ethanol at 60°C, concentrate in vacuum until there is no alcohol smell, add 7 times the amount of distilled water and stir fully, At ~25°C, settle for 8 hours, centrifuge at 3000r / min for 15min, take the sediment, dilute with water, and spray dry to obtain ...

Embodiment 2

[0034] Take 100g of 2-3mm coarse particles of Dioscorea chinensis, put it into a medicinal vacuum composite bag, add 6 times the amount of 100% ethanol, seal it, soak it for 3 hours, put it in the liner of the ultra-high pressure extraction equipment, start the electric heating, and put the The temperature rises to 60°C, the pressure rises to 500MPa within 5 minutes, maintains for about 10 minutes, and then instantly reduces the pressure to zero within 2 seconds. Collect the ultra-high pressure extract, filter the extract, and reserve the filtrate for later use. Put the residual drug residue into a filter bag, centrifuge at 5000r / min for 15min, collect the centrifuged supernatant and combine it with the filtrate, recover ethanol at 60°C, concentrate in vacuo until there is no alcohol smell, add 8 times the amount of distilled water and stir thoroughly, at 20 At ~25°C, settle for 10 hours, centrifuge at 2000r / min for 20min, take the sediment, dilute with water, and spray dry to...

Embodiment 3

[0036]Take 100g of 2-3mm coarse particles of Dioscorea chinensis, put it into a medicinal vacuum composite bag, add 10 times the amount of 80% ethanol, seal it, soak it for 4 hours, put it in the liner of the ultra-high pressure extraction equipment, start the electric heating, and put the The temperature rises to 60°C, the pressure rises to 500MPa within 5 minutes, maintains for about 10 minutes, and then instantly reduces the pressure to zero within 2 seconds. Collect the ultra-high pressure extract, filter the extract, and reserve the filtrate for later use. Put the residual drug residue into a filter bag, centrifuge at 5000r / min for 10min, collect the centrifuged supernatant and combine it with the filtrate, recover ethanol at 60°C, concentrate in vacuum until there is no alcohol smell, add 5 times the amount of distilled water and stir thoroughly, At ~25°C, settle for 6 hours, centrifuge at 4000r / min for 20min, take the sediment, dilute with water, and spray dry to obtain...

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Abstract

The invention which relates to the pharmaceutical chemical field discloses a Dioscorea nipponica Makino saponin extraction method. According to the Dioscorea nipponica Makino saponin extraction method, a required ethanol solvent is once added under a superhigh pressure of 500MPa; Dioscorea nipponica Makino saponins are extracted in an enclosed state; the solvent fully contacts effective components of cells of Dioscorea nipponica Makino tissues and is fully dissolved; the Dioscorea nipponica Makino saponins are transferred to the extract; the extraction time is short; and the extraction rate is high. According to the invention, no solvent is lost in the enclosed state, and residual ethanol is collected by centrifuging the drug residue after extraction, so the organic solvent consumption isreduced, and the production cost is saved. In addition, the temperature required by the extraction method of the invention is low, so the extraction method has the advantages of low energy consumption, energy saving and environmental protection.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a method for extracting diosgenin from pangolin. Background technique [0002] Dioscorea nipponica, aliased as Chuanshanlong, wild yam, Chuandilong, ground keel, and dragon, is the rhizome of Dioscorea dioscorea nipponica makino, which is mainly produced in Jilin, Liaoning, Heilongjiang, Hebei, Shaanxi, Shanxi and other places. Spring, Excavated in autumn, excavated rhizomes, removed cork and fibrous roots, and dried in the sun. The main chemical constituents of Dioscorea chinensis are a variety of steroidal saponins such as dioscin. Modern pharmacological studies have shown that diosgenin has the functions of expectorant, antitussive, asthma, lower cholesterol and blood pressure, slow heart rate, increase the amplitude of cardiac contraction, and improve coronary circulation. effect. [0003] Most of the existing methods for extracting Dioscorea chinensis use heat reflux ext...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P11/10A61P11/14A61P11/06A61P3/06A61P9/12A61P9/06A61P9/04A61P9/10
Inventor 冯涛金爱玉白凤英
Owner JILIN HONGJIU BIO TECH
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