Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Active fraction in lucid ganoderma fruiting body, extracting method, application thereof and preparation

A technology of Ganoderma lucidum fruiting bodies and effective parts, which can be applied to medical preparations containing active ingredients, medical formulas, plant raw materials, etc., and can solve problems such as insufficient research

Active Publication Date: 2012-03-14
上海复浩生物科技有限公司
View PDF2 Cites 18 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on Ganoderma lucidum extract and its medicinal effects, especially the hypoglycemic effect is not sufficient, and there has been no literature report on the effective part extracted from the fruiting body of Ganoderma lucidum that has a significant hypoglycemic effect.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Active fraction in lucid ganoderma fruiting body, extracting method, application thereof and preparation
  • Active fraction in lucid ganoderma fruiting body, extracting method, application thereof and preparation
  • Active fraction in lucid ganoderma fruiting body, extracting method, application thereof and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] 10g of ganoderma lucidum fruiting body raw material (purchased from Leiyunshang, place of origin Jilin) ​​was defatted three times with 95% by volume medicinal ethanol at a degreasing temperature of 70°C for 5 hours each time. (Defatted product) was extracted twice with 1M sodium carbonate aqueous solution at 20°C for 12 hours, the extract was filtered, 1M hydrochloric acid was neutralized to neutrality, concentrated under reduced pressure to obtain an alkali extraction concentrate, and the 1kDa dialysis bag was dialyzed for 2 day, the solution in the dialysis bag was concentrated to 1 / 5 volume, and 0.50 g of the extract was obtained after direct freeze-drying (yield 5.0%).

Embodiment 2

[0089] Adopt the same method as Example 1 to obtain the alkali extraction concentrated solution through dialysis, add 95% ethanol by volume of 5 times the volume of the solution, leave it at room temperature for 12 hours, centrifuge to collect the supernatant, freeze-dry to obtain 0.42g of Ganoderma lucidum extract (produced rate of 4.2%).

Embodiment 3

[0091] 10g of Ganoderma lucidum fruiting body raw material (purchased from Leiyunshang, place of origin Jilin) ​​was refluxed with 95% by volume of medicinal ethanol to degrease 3 times at a degreasing temperature of 78°C for 5 hours each time, and the degreased filter residue was air-dried. The product (defatted product) was extracted twice at 20°C with 1M sodium hydroxide solution, the extraction time was 24 hours, the extract was filtered, 1M hydrochloric acid was neutralized to neutrality, concentrated under reduced pressure to obtain an alkali extraction concentrate, 1kDa dialysis bag water Dialyze for 2 days, concentrate the solution in the dialysis bag to 1 / 5 volume, add 95% ethanol by volume 5 times the volume of the solution, leave it at room temperature for 12 hours, centrifuge to collect the supernatant, freeze-dry to obtain 0.40 g of Ganoderma lucidum extract (yield 4.0%).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an active fraction in a lucid ganoderma fruiting body, an extracting method, application thereof and a preparation. The activity half suppression ratio IC50 of the active fraction on protein tyrosine phosphatase-1B is below 80 mug / mL, and has a remarkable blood sugar reducing effect.

Description

technical field [0001] The invention belongs to the field of medicine or health products, and in particular relates to an effective part for lowering blood sugar in the fruit body of ganoderma lucidum, a method for extracting the effective part from the fruit body of ganoderma lucidum and its application. Background technique [0002] Ganoderma [ Ganoderma lucidum (Fr.) Karst] is a fungus belonging to the genus Ganoderma lucidum of the basidiomycete class. It has been known as "immortal grass" and "auspicious grass" since ancient times. It is a precious traditional Chinese medicine that strengthens the body and strengthens the body. The medicinal value is extremely high, and it is regarded as a precious Chinese medicinal material, and it is a treasure in the treasure house of traditional Chinese medicine. The "Shen Nong's Materia Medica" of the Eastern Han Dynasty listed Ganoderma lucidum as the top grade, and believed that it could "benefit the heart and qi", "calm the so...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61P1/16A61P3/04A61P3/06A61P3/10A61P9/10A61P13/12A61P17/02A61P25/00A61P27/12
CPCA61K36/074A61P1/16A61P3/00A61P3/04A61P3/06A61P3/10A61P7/00A61P9/00A61P9/10A61P9/12A61P13/12A61P17/02A61P25/00A61P25/02A61P27/02A61P27/12
Inventor 周平杨宏杰滕宝松王晨栋
Owner 上海复浩生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com