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Microbicidal compositions including activated nitrogenous compound and 1,4-bis (bromoacetoxy)-2-butene, and methods of using the same

A technology of bromoacetoxy and nitrogen compounds, which is applied in the field of compositions for controlling microbial growth in water systems, can solve problems such as increased processing costs, and achieve the effects of reducing adverse side effects and high antimicrobial efficacy

Inactive Publication Date: 2012-02-08
BUCKMAN LAB INT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to increased disposal costs due to the addition of a greater proportion of oxidizing biocides, adverse side effects of strong oxidizing agents, such as those on systems and other process chemicals, adversely affect both the system and the final product

Method used

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  • Microbicidal compositions including activated nitrogenous compound and 1,4-bis (bromoacetoxy)-2-butene, and methods of using the same
  • Microbicidal compositions including activated nitrogenous compound and 1,4-bis (bromoacetoxy)-2-butene, and methods of using the same
  • Microbicidal compositions including activated nitrogenous compound and 1,4-bis (bromoacetoxy)-2-butene, and methods of using the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] Ammonium sulfate in the form of BUSPERSE 2454 from Buckman Laboratories (Memphis, Tenn) as a nitrogen-containing compound (activated N-compound) and 1,4-bis(bromoacetoxy)-2-butene (BBAB )Compositions. The amounts of nitrogen-containing compounds activated by oxidizing agents shown in Table 1 are based on the active ingredient alone. Introduced from Buckman Laboratories (Memphis, Tenn.) 1210's BBAB in the form of an emulsion. The amounts of BBAB shown in Table 1 are based on the active ingredient of BBAB alone, not on the total amount of the emulsion. The organism tested was Enterobacter aerogenes (ATCC 13048). The incubation period was 18 hours (37°C).

[0127] Table 1

[0128]

[0129] Mic A = alone activated N-compound MIC= 5.0 mg. / l

[0130] Mic B = MIC of BBAB alone = 40 mg. / l

[0131] [A] = Combining individual BBAB activated N-compound MIC (mg. / l)

[0132] [B] = MIC of individual BBAB combined with BBAB (mg. / l)

[0133] * = value < 1 indicates...

Embodiment 2

[0135] Synergy in the presence of sulfites . The efficacy of the actives and mixtures was evaluated in a white water (ww) sample containing 12.8 ppm of sulfite. Two ATP measurements were performed and percent inhibition was calculated as a measure of antimicrobial efficacy. Raw data were converted to percent inhibition by using the following formula:

[0136] % inhibition=[(u-t) / u]×100

[0137] in:

[0138]u = at time 10分钟 ATP value of unprocessed ww

[0139] t = at time 10分钟 The ATP value of ww after treatment

[0140] The data in Table 2 demonstrate the synergistic activity of the compounds with a 20 minute delay between additions and a 10 minute incubation before measuring ATP values.

[0141] Table 2

Embodiment 3

[0143] Evaluation of the synergistic effect against filamentous bacteria . The Fractional Inhibitory Concentration Index (FIC) was determined using the checkerboard method as an index of synergy between activated N-compounds and Busan 1210 (BBAB) against pure isolates of filamentous bacteria cultured from paper mill sludge deposits. predictor. Isolates were identified by 16S ribosomal RNA sequencing technology. MicroSeq data analysis and identification software was used for gene assembly and data analysis; isolates were identified as Flectobacillus strains.

[0144] The modified basal medium buffer was inoculated with a suspension of the bacterial isolate to obtain a final concentration of 1 × 10 5 cells. There was a delay between additions, Busan 1210 (BBAB) was added 20 minutes before monochloramine (MCA) was added. After an exposure time of 3 hours, the treatment reagents were sub-cultured on nutrient and plate count agar (PCA) and incubated at 28°C for 48 hours. Pla...

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Abstract

Microbicidal compositions for aqueous systems are provided that include (a) a nitrogenous compound activated by an oxidant or an enzyme and (b) 1,4-bis(bromoacetoxy)-2- butene (BBAB). The components are present in a combined amount synergistically effective to control the growth of at least one microorganism. Methods for controlling the growth of microorganisms in aqueous systems with the compositions are also provided.

Description

Background of the invention [0001] This application claims priority under U.S.C 35 Section 119(e) of earlier U.S. Provisional Patent Application No. 61 / 143,180 (dated January 8, 2009), the entire contents of which are incorporated herein by reference. [0002] The present invention relates to compositions and methods for controlling the growth of microorganisms in aqueous systems. More specifically, the present invention relates to the treatment of aqueous systems with synergistic mixtures or combinations of nitrogen-containing compounds and 1,4-bis(bromoacetoxy)-2-butene activated by oxidizing agents or enzymes. [0003] Biocides are used to destroy or control the growth of microorganisms in different environments and industries. Depending on their mode of action and chemical profile, biocides are generally classified as oxidizing or non-oxidizing; their successful application depends on their range of pH and / or temperature sensitivity, chemical sensitivity and / or compatibil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/02A01N59/00A01N37/12A01P1/00A01P3/00A01P13/00C02F1/50A01N63/50
CPCA01N37/12A01N59/02C02F1/50Y02A50/30A01N63/50A01N25/04A01N59/00A01N2300/00
Inventor D.A.马雷斯
Owner BUCKMAN LAB INT INC
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