Method for extracting theophylline sodium salt or theophylline by styrene type macroporous resin
A technology for theophylline sodium salt and theophylline, which is applied in the field of extraction of theophylline sodium salt or theophylline, which can solve the problems of loss of octanol and other organic solvents, high recovery costs, loss of target isolates, etc., to enhance competitiveness , Adapt to large-scale production and reduce extraction costs
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Embodiment 1
[0036] A manufacturer produces the mother liquor of theophylline sodium salt, and the content of theophylline sodium salt in the mother liquor is 0.8%. Add 4% hydrochloric acid to adjust the pH to pH 5.0, and filter out the suspended impurities in the mother liquor. In a stainless steel resin column with a diameter of 200 mm and a height of 2000 mm, 50 L of LX-18M styrene type macroporous adsorption resin produced by Xi'an Lanxiao Technology Co., Ltd. was loaded. The mother liquor from which impurities are filtered out is passed through the resin column at a flow rate of 50-100L / h, and a total of 600L of mother liquor is passed through. Use 4% NaOH solution to desorb the resin, the flow rate is 25L / h, and the dosage is 50L. Recover 50 L of the desorption solution, add 32% NaOH solution to adjust the pH value to pH 14, then let it stand, centrifuge, and dry to obtain 4.5 kg of theophylline sodium salt crude product with a content of 92.0%.
Embodiment 2
[0038] A manufacturer produces mother liquor of theophylline, the content of theophylline in the mother liquor is 1.0%. Add sulfuric acid with a concentration of 3%, adjust the pH value to pH4.8, and filter out the suspended impurities in the mother liquor. In a stainless steel resin column with a diameter of 200 mm and a height of 2000 mm, 50 L of LX-18M styrene type macroporous adsorption resin produced by Xi'an Lanxiao Technology Co., Ltd. was loaded. The mother liquor from which impurities are filtered out is passed through the resin column at a flow rate of 100-200L / h, and a total of 500L of mother liquor is passed through. Use 6% KOH solution to desorb the resin, the flow rate is 30L / h, and the dosage is 50L. Recover 50 L of the desorption solution, add 30% sulfuric acid solution to adjust the pH value to pH = 5.0, then let it stand, centrifuge, and dry to obtain 4.8 kg of theophylline crude product with a content of 91.0%.
Embodiment 3
[0040] A manufacturer produces the mother liquor of theophylline sodium salt, and the content of theophylline sodium salt in the mother liquor is 0.2%. Add citric acid with a concentration of 4%, adjust the pH value to pH6, and filter out the suspended impurities in the mother liquor. In a stainless steel resin column with a diameter of 200 mm and a height of 2000 mm, 50 L of LX-20 styrene-type macroporous adsorption resin produced by Xi'an Lanxiao Technology Co., Ltd. was loaded. The mother liquor from which impurities are filtered out is passed through the resin column at a flow rate of 200-300L / h, and a total of 900L of mother liquor is passed through. Use 30% KOH solution to desorb the resin, the flow rate is 5L / h, and the dosage is 20L. Recover 20 L of the desorption solution, add 20% citric acid solution to adjust the pH value to pH 11, then let it stand, centrifuge, and dry to obtain 1.5 kg of crude theophylline sodium salt with a content of 86.0%.
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