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Uniform molecularly imprinted polymer microspheres for use as zeranol selective adsorbent, preparation method and application thereof

A technology of zearalanol and molecular imprinting, applied in alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., can solve the problems of cumbersome operation, poor reproducibility, and large waste

Inactive Publication Date: 2012-02-01
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the obtained molecularly imprinted polymers (CDHB-MIPs) are also in the form of blocks, which also need to be ground and sieved. The operation is cumbersome, wasteful, and the reproducibility is not good.

Method used

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  • Uniform molecularly imprinted polymer microspheres for use as zeranol selective adsorbent, preparation method and application thereof
  • Uniform molecularly imprinted polymer microspheres for use as zeranol selective adsorbent, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] First prepare the dispersed phase solution, ultrasonically dissolve 1 mmol of the template molecule CDHB in 5 mL of the porogen chloroform and ethyl acetate (1:1 by weight), add 4 mmol of the functional monomer 4-vinylpyridine, 19 mmol of the cross-linking agent EDMA, Initiator azobisisobutyronitrile AIBN 0.20g, the solution was ultrasonically degassed for 5min, deoxygenated by nitrogen for 10min, and then the solution was moved into the syringe of the syringe pump (try to avoid air entering the syringe); the continuous phase solution was prepared, and the dispersed PVA 0.72g was added into 60mL water, stirred and dissolved, degassed by ultrasonic for 5min, deaerated by nitrogen gas for 20min, and placed in the continuous phase container.

[0041] The continuous phase was stirred at 210 rpm and sparged with nitrogen. Driven by the syringe pump, the dispersed phase solution enters the square chamber of the microfluidic device through the connecting tube, and then enters ...

Embodiment 2

[0046] First prepare the dispersed phase solution, ultrasonically dissolve 1 mmol of the template molecule CDHB in 6 mL of the porogen chloroform and ethyl acetate (4:6 by weight), add 3 mmol of the functional monomer allylpiperazine, 18 mmol of the cross-linking agent EDMA, Initiator azobisisobutyronitrile AIBN 0.22g, the solution was ultrasonically degassed for 5min, deoxygenated by nitrogen gas for 10min, and then the solution was moved into the syringe of the syringe pump (try to avoid air entering the syringe); the continuous phase solution was prepared, and the dispersed Add 0.78g of agent PVA into 66mL of water, stir to dissolve, ultrasonically degas for 5min, pass nitrogen gas for deoxygenation for 20min, and place in a continuous phase container.

[0047] The continuous phase was stirred at 230 rpm and sparged with nitrogen. Driven by the syringe pump, the dispersed phase solution enters the square chamber of the microfluidic device through the connecting tube, and th...

Embodiment 3

[0052] First prepare the dispersed phase solution, ultrasonically dissolve 1 mmol of the template molecule CDHB in 9 mL of the porogen chloroform and ethyl acetate (4:6 by weight), add 5 mmol of the functional monomer allylpiperazine, 30 mmol of the cross-linking agent EDMA, Initiator azobisisobutyronitrile AIBN 0.22g, the solution was ultrasonically degassed for 5min, deoxygenated by nitrogen gas for 10min, and then the solution was moved into the syringe of the syringe pump (try to avoid air entering the syringe); the continuous phase solution was prepared, and the dispersed Add 1.28g of agent PVA into 90mL of water, stir to dissolve, ultrasonically degas for 5min, pass nitrogen gas for deoxygenation for 20min, and place in a continuous phase container.

[0053] The continuous phase was stirred at 180 rpm and sparged with nitrogen. Driven by the syringe pump, the dispersed phase solution enters the square chamber of the microfluidic device through the connecting tube, and th...

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Abstract

The invention relates to uniform molecularly imprinted polymer microspheres for use as a zeranol selective adsorbent. With an average particle size of 1 micrometer to 300 micrometers and a particle size distribution coefficient C.V. of not greater than 15%, the molecularly imprinted polymer microspheres are prepared by the method of: taking a structural analog cyclododecyl 2, 4-dihydroxybenzoate (CDHB) of zeranol as a template molecule, employing a microfluidic device to prepare microspheres of molecularly imprinted polymers (MIPs) of CDHB (CDHB-MIPs), with the microspheres characterized by good particle size uniformity and good selective absorption capacity for zeranol; placing the microfluidic device containing multiple micro channels below the liquid level of a continuous phase, making the continuous phase flow at a certain rotating speed, driving a disperse phase solution with CDHB into the microfluidic device by an injection pump, generating an emulsion when the disperse phase enters the continuous phase through the micro channels, curing the emulsion droplets so as to obtain polymer microspheres, eluting the polymer microspheres to remove the template molecule, thus obtaining the molecularly imprinted polymer microspheres of CDHB. Specifically, the disperse phase includes the template molecule CDHB, a functional monomer, a cross-linking agent, an initiator and a porogenic solvent, while the continuous phase contains water and a dispersing agent.

Description

technical field [0001] The invention relates to the fields of functional polymer materials, biochemical separation and analytical chemistry. More specifically, it relates to a molecularly imprinted polymer microsphere of cyclododecyl 2,4-dihydroxybenzene. [0002] The present invention also relates to a preparation method of the molecularly imprinted polymer microsphere. [0003] The present invention also relates to the application of the molecularly imprinted polymer microspheres. Background technique [0004] Zearalanol (zeranol, α-zearalanol, α-ZAL), also known as "right ring tetradecone phenol", belongs to zearalanol and is a derivative of dihydroxybenzoic acid lactone in Gibberella zeae. Non-steroidal anabolic hormones. Zearalanol can improve the carcass lean meat rate and feed conversion rate of cattle and sheep. It has been used as a weight-increasing agent for cattle and sheep in the form of implantation to promote protein synthesis and weight gain of cattle and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30C08F222/14C08F226/06C08F220/34C08F2/44C08J9/26
Inventor 雷建都马光辉苏志国寇星翟艳琴
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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