Photosensitive medicament patch and preparation method thereof

A technology of photosensitive drugs and patches, which is applied in the direction of drug combinations, pharmaceutical formulations, antineoplastic drugs, etc., can solve the problems of unguaranteed phototherapy effect, strong skin discomfort, and difficulty in controlling dosage, so as to achieve good biodegradability and promote Effects on wound healing, good biocompatibility

Active Publication Date: 2012-02-01
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since Hypocretin ointment is a traditional ointment, there are some shortcomings in the long-term use process, such as its auxiliary materials are oily base and polar organic solvents, high toxicity, poor absorption performance in product application, The skin discomfort is strong, and the phototherapy effect cannot be guaranteed, and when the patient uses it, it is difficult to control the dosage each time, and film packaging is required

Method used

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  • Photosensitive medicament patch and preparation method thereof
  • Photosensitive medicament patch and preparation method thereof
  • Photosensitive medicament patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] According to the method of the present invention, the L-alpha-ditetradecylphosphatidic acid (DMPA) of getting 10mg is dissolved in the mixed solution (1: 1) of chloroform and methyl alcohol, then adds the hyporubin ( HB), evaporate the solvent after completely dissolving, add 10ml of PBS buffer solution after vacuum drying, and perform ultrasonic treatment to obtain DMPA-HB solution.

[0038] In addition, DMPA can also be replaced by DMPC or other materials known to those skilled in the art.

[0039] Prepare 1% chitosan acetic acid aqueous solution and stir to dissolve it completely, the casting solution is decompressed and degassed, cast in a petri dish at room temperature to form a film, and after drying, spread the above prepared DMPA-HB solution on the chitosan Sugar homogeneous film, dried to prepare CHIDMPA-HB drug-loaded film. As shown in the attached picture.

[0040] The medical film, adhesive plaster layer, and light-shielding protective layer are processed ...

Embodiment 2

[0042]According to the method of the present invention, the L-alpha-ditetradecylphosphatidic acid (DMPA) of getting 10mg is dissolved in the mixed solution (1: 1) of chloroform and methyl alcohol, then adds the Hypocretin A of 0.5% molar amount ( HA), evaporate the solvent after complete dissolution, add 10ml of PBS buffer solution after vacuum drying, and perform ultrasonic treatment to obtain DMPA-HA solution.

[0043] Prepare 2% chitosan acetic acid aqueous solution and stir to dissolve it completely. The casting solution is degassed under reduced pressure, and cast in a petri dish at room temperature to form a film. After drying, spread the above prepared DMPA-HA solution on the chitosan Sugar homogeneous film, dried to prepare CHIDMPA-HA drug-loaded film.

[0044] The medical film, adhesive plaster layer, and light-shielding protective layer are processed and produced according to the production process of the patch.

Embodiment 3

[0046] According to the method of the present invention, 5 mg of L-α-ditetradecylphosphatidic acid (DMPA) is dissolved in a mixed solution of chloroform and ethylene glycol (9: 1), and then 0.8% molar amount of 5-amino After levulinic acid (ALA) is completely dissolved, the solvent is evaporated, after vacuum drying, 10 ml of PBS buffer solution is added, and ultrasonic treatment is performed to obtain a DMPA-ALA solution.

[0047] Prepare 2% chitosan acetic acid aqueous solution and stir to dissolve it completely. The casting solution is degassed under reduced pressure, cast in a petri dish at room temperature to form a film, and after drying, spread the DMPA-ALA solution prepared above on the chitosan sugar homogeneous film, dried to prepare CHIDMPA-ALA drug-loaded film.

[0048] The medical film, adhesive plaster layer, and light-shielding protective layer are processed and produced according to the production process of the patch.

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Abstract

The invention relates to a photosensitive medicament patch, which comprises a light-isolating protection layer, an adhesive plaster layer, a membrane layer and a medicament core and is characterized in that the medicament core formed by encapsulating a medicament with phospholipids and is attached onto the membrane layer, and the membrane layer is made of a natural biomaterial homogeneous membrane. According to the photosensitive medicament patch provided by the invention, not only can the requirement of a parenteral medicament administration manner of a photosensitive medicament be met and hypocrellin be enriched in a target tissue, but also the photosensitive medicament can be prevented from auto polymerization in a water phase, so that the purpose of increasing phototherapy activity is increased. In addition, the natural biomaterial homogeneous membrane has favorable biodegradability and biocompatibility, has no toxicity and antigenicity, has favorable functions of air permeability, membrane formability, spinnability, blood coagulation resistance, and capability of promoting wound healing, corrosion protection and antisepsis, and the like, and serves as a medicament slow-release carrier in the invention.

Description

technical field [0001] The purpose of the present invention is to provide a photosensitive drug patch and its preparation method, more specifically, to provide a hypocretin patch and its preparation method, so as to provide a new composite phototherapy reagent for photodynamic therapy. Background technique [0002] Photodynamic therapy (PDT for short) is a new clinical treatment technology under research and development. Photodynamic therapy began to be used in the clinical diagnosis and treatment of malignant tumors in the late 1970s. It has also been successfully applied in antiviral and photodynamic pesticides. The direction of development, such as the treatment of port wine stains, microvascular diseases, macular degeneration and atherosclerosis, etc., and made outstanding progress. However, compared with therapy, the development of photodynamic drugs is seriously lagging behind. Therefore, high-efficiency, low-toxic photosensitizers are still the goal that people are v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K41/00A61K47/36A61K47/42A61K47/24A61P35/00A61P17/02A61P31/00
Inventor 李峻柏武美霞
Owner INST OF CHEM CHINESE ACAD OF SCI
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