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Applications of isoquinoline-type alkaloid and derivatives thereof in preparing medicaments for preventing or treating cervical cancer

A technology of drugs and compounds, applied in the field of natural drug extracts and pharmaceutical applications, can solve problems such as difficult to achieve long-term therapeutic effects, adverse complications, lack of treatment methods, etc., to achieve the effect of enhancing autoimmune function and improving the body's immunity

Inactive Publication Date: 2012-01-04
王芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the disadvantages of the above-mentioned techniques such as adverse complications during or after treatment, it is often difficult to achieve long-term therapeutic effects.
There is still no effective treatment

Method used

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  • Applications of isoquinoline-type alkaloid and derivatives thereof in preparing medicaments for preventing or treating cervical cancer
  • Applications of isoquinoline-type alkaloid and derivatives thereof in preparing medicaments for preventing or treating cervical cancer
  • Applications of isoquinoline-type alkaloid and derivatives thereof in preparing medicaments for preventing or treating cervical cancer

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0063] The effect of isocydine on the inhibition of cervical cancer in tumor-bearing nude mice

[0064] Drug name: isocydine

[0065] Chemical Name:

[0066] 1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol

[0067] Drug structure:

[0068]

[0069] Dosage form: injection, powder injection

[0070] Administration route: intravenous injection, intravenous infusion

[0071] Experimental animals: female Balb / C mice

[0072] To investigate whether isorydine has inhibitory effect on the tumor growth of human cervical cancer Hela cells and Siha cell nude mice, and whether it can induce cell apoptosis, so as to evaluate the application value of isorydine in the treatment of human cervical cancer.

[0073] Experimental method: Female BALB / C nude mice, 6-8 weeks old, weighing 20-30g, digested Hela cells and Siha cells with logarithmic growth with 0.25% trypsin, then centrifuged and washed twice with serum-free culture medium, Adjust cell density to...

example 2

[0076] Effect of corydine on inhibiting cervical cancer in tumor-bearing nude mice

[0077] Drug name: Corydaline

[0078] Chemical Name:

[0079] (6aS)-2,10,11-Trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

[0080] Drug structure:

[0081]

[0082] Dosage form: injection, powder injection

[0083] Administration route: intravenous injection, intravenous infusion

[0084] Experimental animals: female Balb / C mice

[0085] To investigate whether cordydine can inhibit the tumor growth of human cervical cancer Hela cells and Siha cells in nude mice, and whether it can induce cell apoptosis, so as to evaluate the application value of cordydine in the treatment of human cervical cancer.

[0086] Experimental method: Female BALB / C nude mice, 6-8 weeks old, weighing 20-30g, digested Hela cells and Siha cells with logarithmic growth with 0.25% trypsin, then centrifuged and washed twice with serum-free culture medium, Adjust cell density to 1x10 7 cells / m...

example 3

[0089] The effect of isoboldine on inhibiting cervical cancer in tumor-bearing nude mice

[0090] Drug name: Isoboldine

[0091] Chemical Name:

[0092] (6aS)-2,10-Dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,9-diol

[0093] Drug structure:

[0094]

[0095] Dosage form: injection, powder injection

[0096] Administration route: intravenous injection, intravenous infusion

[0097] Experimental animals: female Balb / C mice

[0098] To investigate whether isoboldine can inhibit the tumor growth of human cervical cancer Hela cells and Siha cells in nude mice, and whether it can induce cell apoptosis, so as to evaluate the application value of isoboldine in the treatment of human cervical cancer.

[0099] Experimental method: Female BALB / C nude mice, 6-8 weeks old, weighing 20-30g, digested Hela cells and Siha cells with logarithmic growth with 0.25% trypsin, then centrifuged and washed twice with serum-free culture medium, Adjust cell density to 1x10 7 cells...

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Abstract

The invention relates to isoquinoline-type alkaloid for preventing and treating cervical cancer, belonging to the fields of preparation technique of natural medicament extractives and antitumor medicines. The invention also relates to applications of bulbocapnine, isocorydine, isoboldine, N-methyl hernovine, dicranostigma alkaloid or pharmaceutically acceptable salts or esters thereof in the preparation of medicaments for preventing and treating cervical cancer.

Description

technical field [0001] The invention relates to an isoquinoline alkaloid and its derivatives, and uses thereof, belonging to the technical field of natural medicine extracts and pharmaceutical applications. Background technique [0002] Cervical cancer is the second most common malignant tumor in women's death after breast cancer in the world. It is characterized by high malignancy and poor cure rate. According to the survey by WHO in 2006, there are 490,000 new cases of cervical cancer in the world every year, and more than 270,000 deaths, 85% of which are found in developing countries, seriously endangering women's health, and epidemiological surveys show that the incidence rate has increased in recent years The trend is that the age of onset tends to be younger. At present, the clinical treatment methods for cervical cancer include three main methods: surgical resection, drug chemotherapy and radiation therapy. In addition, there are emerging biological treatment techniq...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/473A61P35/00A61P37/04
Inventor 王芳樊鹏程
Owner 王芳
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