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Carboxymethyl chitosan/ polyvinyl alcohol porous composite material and preparation method thereof

A technology of carboxymethyl chitosan and porous composite materials, applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problems of poor antibacterial and anti-inflammatory effects, achieve excellent antibacterial effect, good biocompatibility, and be suitable for industrial production. Effect

Inactive Publication Date: 2011-12-21
威海世创医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, various hemostatic materials have been prepared by modified polyvinyl alcohol materials on the market, which have excellent hemostatic effect, but poor antibacterial and anti-inflammatory effects
At present, there are few reports on carboxymethyl chitosan / polyvinyl alcohol composite materials.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Raw material composition and weight ratio: carboxymethyl chitosan 10%, polyvinyl alcohol 20%, acetic acid 3%, solubility of 37% hydrochloric acid 5%, formaldehyde 5%, sodium bicarbonate 12%, nano silver 0.4%, Polyoxyethylene 1%, the rest is distilled water.

[0028] Put the carboxymethyl chitosan into a container with an aqueous acetic acid solution and mix, at a temperature of 20-50 °C, stir until it is completely dissolved; put the polyvinyl alcohol into the water at 20-50 °C to completely dissolve, and then Pour a certain amount of hydrochloric acid, heat it up to 60-100 °C, and under the action of mechanical stirring until it is completely dissolved; pour it into a container containing an aqueous solution of carboxymethyl chitosan, stir evenly, and heat up to 60-100 °C, Put formaldehyde, sodium bicarbonate, nano-silver particles, and polyethylene oxide into the container containing the above mixed solution, under mechanical stirring, introduce low-pressure compresse...

Embodiment 2

[0030] Raw material composition and weight ratio: carboxymethyl chitosan 15%, polyvinyl alcohol 25%, acetic acid 3%, solubility of 37% hydrochloric acid 5%, glutaraldehyde 8%, foaming agent 2%, antibacterial agent 0.5% %, softener 2%, and the rest is distilled water.

[0031] Put the carboxymethyl chitosan into a container with an aqueous acetic acid solution and mix, at a temperature of 20-50 °C, stir until it is completely dissolved; put the polyvinyl alcohol into the water at 20-50 °C to completely dissolve, and then fall

[0032] Add a certain amount of hydrochloric acid, heat it up to 60-100 °C, and under the action of mechanical stirring until it is completely dissolved; pour it into a container containing an aqueous solution of carboxymethyl chitosan, stir evenly, and heat it up to 60-100 °C. Put glutaraldehyde, ammonium bicarbonate, nano-silver particles, and emulsified silicone oil into the above mixed liquid container, continue to react at 60-100 ℃ for 6 hours under...

Embodiment 3

[0034] Raw material quality ratio: carboxymethyl chitosan 22%, polyvinyl alcohol 30%, acetic acid 3%. Sulfuric acid 10%, paraformaldehyde 5%, foaming agent 3%, antibacterial agent 0.8%, softener 3%, and the rest is distilled water.

[0035] Put the carboxymethyl chitosan into a container with an aqueous acetic acid solution and mix, at a temperature of 20-50 °C, stir until it is completely dissolved; put the polyvinyl alcohol into the water at 20-50 °C to completely dissolve, and then Pour a certain amount of sulfuric acid, heat it up to 60-100 ℃, under the action of mechanical stirring until it is completely dissolved; pour it into a container containing an aqueous solution of carboxymethyl chitosan, stir evenly, and heat up to 60-100 ℃, Put glutaraldehyde, ammonium bicarbonate, silver sulfadiazine particles, and emulsified silicone oil into a container containing the above mixed solution, continue to react at 60-100 ° C for 6 hours under mechanical stirring, cool to room tem...

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PUM

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Abstract

The invention relates to a carboxymethyl chitosan / polyvinyl alcohol porous composite material, which comprises the following raw materials in percentage by weight: 4 to 22 percent of carboxymethyl chitosan, 10 to 30 percent of polyvinyl alcohol, 3 to 5 percent of acetic acid, 5 to 10 percent of inorganic acid, 5 to 10 percent of cross-linking agent, 1 to 5 percent of foaming agent, 0.5 to 2 percent of antibacterial agent, 1 to 5 percent of softening agent and the like. A preparation method for the composite material comprises the following steps of: stirring the polyvinyl alcohol till full dissolution, pouring the dissolved polyvinyl alcohol into the dissolved carboxymethyl chitosan, adding the inorganic acid, the cross-linking agent, the foaming agent, the softening agent and the antibacterial agent, heating the solution to the temperature of between 90 and 100 DEG C, pouring the solution into a die, continuously reacting the solution for 6 to 9 hours at the temperature of between 60 and 100 DEG C, cooling the product, and repeatedly washing the product by using distilled water. The prepared material has the characteristics of good biocompatibility, excellent antibacterial effect, strong solution absorption, biodegradability, good attachment to the skin and the like, is quick in hemostasis, antibacterial and anti-inflammatory, has the function of promoting wound healing, and is suitable for making various wound dressings.

Description

technical field [0001] The invention relates to a medical biological material, in particular to a carboxymethyl chitosan / polyvinyl alcohol porous composite material with antibacterial and anti-inflammatory functions and a preparation method thereof. Background technique [0002] We know that carboxymethyl chitosan has excellent properties such as good biocompatibility, antibacterial, hemostasis and wound healing, biodegradability and good adhesion to the skin. Carboxymethyl chitosan has broad application prospects in the fields of wound dressings, hemostatic materials, tissue engineering scaffolds and drug release. However, the mechanical properties of carboxymethyl chitosan are poor. [0003] The polyvinyl alcohol is a water-soluble synthetic polymer, has a strong ability to absorb liquid, while no leakage. At present, various hemostatic materials have been prepared on the market by modified polyvinyl alcohol materials, which have excellent hemostatic effects, but poo...

Claims

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Application Information

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IPC IPC(8): C08L29/04C08L5/08C08J9/04C08J9/08C08J9/12A61L15/28A61L15/24A61L15/42
Inventor 杜兰平万风云
Owner 威海世创医疗科技有限公司
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