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A kind of preparation method of high-purity glyceride type fish oil

A high-purity technology for glyceride-based fish, which is applied in the direction of fatty acid esterification, fatty acid production, and chemical modification of fatty acids. The effect of high purity and price reduction

Active Publication Date: 2011-12-14
山东禹王制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is: the cost is extremely high, and the field of medicine and chemical industry cannot use this method to industrially prepare glyceride-type fish oil
The deficiencies of these methods lead to the high price and low purity of glyceride fish oil as raw materials of medicines and health products. This problem has not been solved for a long time in this field, which limits the application range of glyceride fish oil.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0015] Example 1: The preparation method of the present invention adopts industrially produced ethyl ester fish oil as raw material to prepare high-purity glyceride fish oil. The ethyl ester fish oil contains 46% EPA and 27% DHA. The steps of the preparation method are as follows:

[0016] ① Take 650g of ethyl ester fish oil and 180g of alkali according to the weight ratio, dissolve 180g of alkali in 1.6L of water, put them into the reactor, add 0.4L of ethanol into the reactor at room temperature, mix well, add ethyl ester of fish oil ;

[0017] ② Fill the reactor with nitrogen, heat the material to 70°C under the protection of nitrogen, and react for 1 hour until the material reacts completely;

[0018] ③Reduce the material temperature in the reactor to 5°C, then add 2N hydrochloric acid to adjust the pH value to 2;

[0019] ④ Extract with petroleum ether 250ml×3, wash the organic layer with saturated NaCl solution 300ml×3, then dry with magnesium sulfate for 1 hour, and ev...

example 2

[0024] Example 2: The preparation method of the present invention adopts industrially produced ethyl ester fish oil as raw material to prepare high-purity glyceride fish oil. The ethyl ester fish oil contains 50% EPA and 25% DHA. The steps of the preparation method are as follows:

[0025] ① Take 650g of ethyl ester fish oil and 110g of alkali according to the weight ratio. Dissolve 110g of alkali in 0.4L of water and put them into the reactor. ;

[0026] ② Fill the reactor with nitrogen, heat the material to 80°C under the protection of nitrogen, and react for 1.5 hours until the material reacts completely;

[0027] ③Reduce the temperature of the material in the reactor to 18°C, and then add an appropriate amount of dilute acid to adjust the pH value to 3;

[0028] ④Extract with 200ml×3 n-hexane, wash the organic layer with 300ml×3 saturated NaCl solution, then dry with anhydrous sodium sulfate for 2 hours, evaporate the solvent under reduced pressure to obtain 550g free pol...

example 3

[0033] Example 3: The preparation method of the present invention adopts industrially produced ethyl ester fish oil as a raw material to prepare high-purity glyceride fish oil. The ethyl ester fish oil contains EPA62% and DHA21%. The steps of the preparation method are as follows:

[0034] ① Take 800g of ethyl ester fish oil and 160g of alkali according to the weight ratio, dissolve 160g of alkali in 1.0L of water, put them in the reactor, and at the same time add 1L of ethanol to the reactor at room temperature, mix well, and add ethyl ester fish oil;

[0035] ② Fill the reactor with nitrogen, heat the material to 60°C under the protection of nitrogen, and react for 2 hours until the material reacts completely;

[0036] ③Reduce the material temperature in the reactor to 25°C, then add 2N hydrochloric acid to adjust the pH value to 4;

[0037] ④ Extract with petroleum ether 200ml × 3, the organic layer is washed with saturated NaCl solution 300ml × 3, and then dried with magne...

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PUM

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Abstract

The invention discloses a preparation method of glyceride type fish oil, comprising the following steps: (1) taking 650-800g of glyceride type fish oil and 110-180g of alkali at weight ratio, dissolving alkali in 0.4-1.6L of water, evenly mixing in a reactor, and adding the glyceride type fish oil; (2) introducing nitrogen into the reactor until material is completely reacted; (3) cooling materials in the reactor to be below 25DEG C; (4) extracting by petroleum ether or n-hexane to obtain free polyunsaturated fatty acid; (5) adding the free polyunsaturated fatty acid into the reactor; (6) adding zinc powder into the reactor; (7) immediately pouring reaction liquid into crushed ice for quenching reaction; and (8) extracting a crude product subjected to quenching reaction by the petroleum ether or n-hexane, and washing an organic layer with saturated salt water to obtain the glyceride type fish oil. The preparation method disclosed by the invention has the advantages of short preparation time and low manufacture cost, the prepared glyceride type fish oil keeps high content of EPA (Eicosapntemacnioc Acid) and DHA (Docosahexaenic Acid) and also has high content of triglyceride.

Description

technical field [0001] The invention relates to a method for preparing fish oil, which is a method for preparing high-purity glyceride type fish oil. Background technique [0002] Fish oil contains eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) physiologically active components, which are widely used as raw materials for medicines and health products. Fish oil currently on the market is divided into ethyl ester fish oil and glyceride fish oil. Studies in recent years have shown that due to the displacement of ethyl ester fish oil into a certain amount of ethanol during the esterification process, fatty acid imbalance has been caused, which has side effects on the human body after consumption, and the absorption rate of ethyl ester fish oil after oral administration is low. For several years, ethyl ester fish oil has been used as raw material to prepare glyceride fish oil to solve the shortage of ethyl ester fish oil. However, these methods have disadvantages su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11C3/00C11C3/02
Inventor 姚庆强杨尚军仲浩刘拥军赵晓东白少岩刘锡潜范书琴张建全
Owner 山东禹王制药有限公司
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