A composition for preventing and treating lead poisoning and its preparation method

The technology of a composition and an extract, applied in the field of pharmaceutical compositions, can solve the problems of less lead in lowering blood, difficult application of chronic lead poisoning, inconvenient use, etc., and achieves the effects of suitable concentration, easy absorption by the human body, and good curative effect.

Inactive Publication Date: 2011-12-14
封士兰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to apply to chronic lead poisoning, and it is inconvenient to use. Most metal antagonists and metal chelating agents such as EDTA also have certain toxicity, and there are many problems in repeated long-term use.
[0005] At present, although some achievements have been made in the prevention and treatment of chronic lead poisoning, so far there are few specific drugs for the prevention and treatment of chronic lead poisoning, and there are relatively few Chinese herbal medicines for reducing blood lead.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] This example processes a composition for the prevention and treatment of lead poisoning, including component names and mass percentages: Radix Radix Radix 45g, Angelica 30g, Salvia miltiorrhiza 40g, Lycium barbarum 40g, Poria cocos 45g, Forsythia 30g, Curcuma 30g.

[0039] The preparation method of the composition of preventing and treating lead poisoning described in this example comprises the following steps:

[0040] a) Weigh the above 7 components of medicinal materials, add water 7 times its weight, that is, add 1820ml of water to decoct twice, each time for 2.0 hours, and the time interval between 2 consecutive decoctions is 2.0 hours; combine the decoction obtained The medicinal solution was left to stand for 12 hours;

[0041] b) Concentrate the supernatant of the above-mentioned medicinal solution obtained by standing to obtain an extract, the specific gravity of the extract is 1.5, add 43 parts of dextrin and 17 parts of soluble starch to 40 parts of the extra...

Embodiment 2

[0044] This example processes a composition for the prevention and treatment of lead poisoning. The difference from Example 1 is that the components and contents of this example are adjusted as follows: 5g Radix Radix Radix, Angelica 5g, Salvia miltiorrhiza 5g, Lycium barbarum 5g, Poria cocos 5g, Forsythia 5g, curcuma 5g.

[0045] Preparation method step a) of the composition for preventing and treating lead poisoning described in this example) Take the medicinal materials of the 7 components described in this example, add water 7 times its mass, that is, add 245 parts of water to decoct twice , 2.0 hours each time, the time interval between 2 consecutive decoctions is 2.0 hours; step b) the specific gravity of the extract is 1.1 in this example, and it is spray-dried, and the air inlet temperature of the spray-dried is 150-200°C , the air outlet temperature is 80-100°C, and the size of the spray air flow is 25-200 kg / hour to obtain the extract powder; in the step c) 60g of th...

Embodiment 3

[0047] This example prepares a composition for the prevention and treatment of lead poisoning. The difference from Example 1 is that the components and contents of this example are adjusted as follows: 25g of Radix Radix Radix, 5g of Angelica Sinensis, 20g of Salvia Miltiorrhiza, 15g of Lycium barbarum, 25g of Poria cocos, and Forsythia 15g, Curcuma 15g, by mass.

[0048] The specific gravity of step b) of the extract of the preparation method of the composition for preventing and treating lead poisoning described in this example is 1.3. In this example, the extract is made into a soft material with ethanol, granulated, dried, and packed into a hard capsule to obtain a capsule, and the weights of the extract and ethanol are respectively 10 g and 1 g).

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PUM

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Abstract

The invention provides a composition for preventing and treating lead poisoning and a preparation method thereof. The composition for preventing and treating lead poisoning includes component names and mass percentages: 5-50% of Radix Hegaly, 3-30% of Angelica , Salvia 3-40%, Lycium barbarum 3-40%, Poria cocos 5-50%, Forsythia 3-30%, Curcuma 3-30%; The present invention also provides a preparation method of a composition for preventing and treating lead poisoning, It can effectively reduce the femoral lead, blood lead and liver lead levels of lead poisoning patients, and can effectively improve the learning and memory ability of lead poisoning patients. The invention uses Chinese medicinal materials as raw materials, is non-toxic and has no side effects, and can be taken for a long time. Clinical trials have shown that this The invention can effectively reduce the blood lead level of lead poisoning human body and improve the learning and memory ability of lead poisoning children.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a composition for preventing and treating lead poisoning, and also relates to a preparation method of the composition for preventing and treating lead poisoning. Background technique [0002] With the development of my country's industrialization, some areas blindly pursue the growth of GDP and ignore the protection of the environment, coupled with the inevitable contact between mining areas and smelting enterprises, and the lack of popularization of prevention knowledge, resulting in lead pollution of air, water, food, children's toys, etc. , forming acute and chronic lead poisoning. Lead is toxic to the central nervous system, blood, bones, heart, liver, kidney, etc., and can be damaged by various groups of people. Children are particularly sensitive to lead poisoning, and the damage is particularly serious. Increased blood lead has a negative impact on children's growth and devel...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P39/02
Inventor 封士兰赵健雄赵良功沈孝丽王娟
Owner 封士兰
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