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Application of Scorzonera total extract in preparation of medicaments for treating hepatitis or protecting liver

An extract and a technology of scallion, which are applied to the total extract of scallion and its preparation in the field of treating hepatitis or hepatoprotective medicines, and can solve the problems of elaboration of the pharmacological action of the total extract, and no reports and descriptions of the total extract of saffron.

Inactive Publication Date: 2013-07-24
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Li Quanmiao, Wang Guangshu and others studied the extraction, separation and structural identification of flavonoid glycosides in Saffron onion [J]; Journal of Jilin University (Medical Edition); Issue 01, 2010), but did not further elaborate on the pharmacological effects of the total extract of its effective parts
In addition, in other related documents, there is no report and description on the treatment of hepatitis and hepatoprotective effects of the total extract of Scutellaria japonicus

Method used

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  • Application of Scorzonera total extract in preparation of medicaments for treating hepatitis or protecting liver
  • Application of Scorzonera total extract in preparation of medicaments for treating hepatitis or protecting liver
  • Application of Scorzonera total extract in preparation of medicaments for treating hepatitis or protecting liver

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Embodiment 1: the preparation of the total extract of Saffron onion

[0035] Take a certain amount of macroporous resin, soak it in 95% ethanol for 24 hours, wet-pack the column, and elute it with 95% ethanol until the eluent is mixed with distilled water (1:5) and no turbidity appears. Wash away the ethanol with distilled water, pour out the macroporous resin, and dry it at room temperature.

[0036] Crush the whole herb of Scallops into powder and extract it with 50% ethanol to obtain the ethanol extract of Scallops. Wash the pretreated macroporous resin column on the ethanol extract of Scutellaria japonicus with distilled water to wash water-soluble impurities such as proteins and polysaccharides, then elute with 70% ethanol aqueous solution, collect and concentrate the dried eluent to powder, and obtain total extract.

Embodiment 2

[0037] Embodiment 2: the preparation of the total extract of Saffron onion

[0038] Take a certain amount of macroporous resin, soak it in 95% ethanol for 24 hours, wet-pack the column, and elute it with 95% ethanol until the eluent is mixed with distilled water (1:5) and no turbidity appears. Wash away the ethanol with distilled water, pour out the macroporous resin, and dry it at room temperature.

[0039] Crush the whole herb of Scallops into powder and extract it with 70% ethanol to obtain the ethanol extract of Scallops. Disperse the extract in water, extract with ether, evaporate the ether from the water layer, and put the pretreated macroporous resin column on the ethanol extract of the scallion, wash the water-soluble impurities such as protein and polysaccharide with distilled water, and then use 30% The ethanol aqueous solution was used for elution, and the eluate was collected and concentrated and dried to powder to obtain the total extract.

Embodiment 3

[0040] Embodiment 3: the preparation of the total extract of Saffron onion

[0041] Take a certain amount of macroporous resin, soak it in 95% ethanol for 24 hours, wet-pack the column, and elute it with 95% ethanol until the eluent is mixed with distilled water (1:5) and no turbidity appears. Wash away the ethanol with distilled water, pour out the macroporous resin, and dry it at room temperature.

[0042] Crush the whole herb of Scallops into powder, and extract it with 95% ethanol to obtain the ethanol extract of Scallops. Disperse the extract in water, extract it with petroleum ether, evaporate the ether from the water layer, and put the pretreated macroporous resin column on the ethanol extract of Scutellaria japonica, first wash water-soluble impurities such as protein and polysaccharide with distilled water, and then use 95% The ethanol aqueous solution was used for elution, and the eluate was collected and concentrated and dried to powder to obtain the total extract....

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Abstract

The invention discloses a scorzonera total extract and application thereof to the preparation of medicaments for treating hepatitis or protecting liver. A preparation method for the scorzonera total extract comprises the following steps of: 1) crushing scorzonera whole herbs into powder, extracting by using 30 to 95 percent ethanol, and concentrating to obtain ethanol extractum; 2) loading the ethanol extractum onto a macroporous resin column to perform chromatography; and 3) eluting by using distilled water, eluting the resin column by using 30 to 95 percent of alcohol water solution to obtain eluent, collecting, concentrating and drying the eluent to form powder, namely the scorzonera total extract. The invention also relates to new application of the scorzonera total extract to the preparation of the medicaments for treating the hepatitis or protecting the liver and provides possibility for the preparation and marketing of the two medicaments.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a total extract of Scallops japonicus and its use in preparing medicines for treating hepatitis or protecting liver. Background technique [0002] The liver is the largest and most complex important metabolic organ in the human body. It plays an important role in the metabolism of sugar, lipid, protein, vitamins, hormones, bile and other substances; at the same time, the liver also has functions in secretion, excretion, and biotransformation Function; the liver is also an important shielding organ of the body, and its detoxification function has an important protective effect on the body. Therefore, when the liver function is damaged, it will cause metabolic disorders and affect the functions of other organs, and in severe cases, it will be life-threatening. [0003] Hepatitis is one of the diseases that seriously endanger human health. It is mainly caused by a group of pathogens mainly ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P1/16
Inventor 王广树杨晓虹周小平杨锦竹孙薇陈滴王艳张沐新刘银燕
Owner JILIN UNIV
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