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A kind of quality detection method of traditional Chinese medicine Eucommia ulmoides preparation

A quality inspection method and preparation technology, applied in measuring devices, instruments, scientific instruments, etc., can solve problems such as unavailability, effective control of product quality, and inability to guarantee clinical efficacy, and achieve high precision and good repeatability.

Active Publication Date: 2011-11-30
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for Eucommia preparations, a single index component is currently used for quality control, and its quality control method cannot accurately and comprehensively reflect the internal quality of the product, nor can it be used in the production process and effective control of product quality, let alone guarantee its clinical efficacy

Method used

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  • A kind of quality detection method of traditional Chinese medicine Eucommia ulmoides preparation
  • A kind of quality detection method of traditional Chinese medicine Eucommia ulmoides preparation
  • A kind of quality detection method of traditional Chinese medicine Eucommia ulmoides preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Establishment of standard fingerprints of traditional Chinese medicine Eucommia preparations (Taking Quanducommia Capsules as an example).

[0039] (1) Instruments and reagents: High-performance liquid chromatography: Shimadzu LC-10ATvp high-performance liquid chromatography (SPD-M10Avp detector, CLASS-VP software); CNC ultrasonic cleaner: KQ-250DB, Kunshan Ultrasonic Instrument Co., Ltd.; 1 / 100,000 balance: Shimadzu AUW220; 1 / 10,000 balance: AB104-N type, manufacturer: Mettler-Toledo.

[0040] Acetonitrile: Chemical Branch of Shandong Yuwang Experimental Co., Ltd.; Methanol: Shanghai Zhenxing Chemical Factory No. 1; Phosphoric acid (excellent grade): Tianjin Fine Chemicals Development Co., Ltd.; Potassium dihydrogen phosphate: Shantou Xilong Chemical Factory Co., Ltd.; pure water.

[0041] Chlorogenic acid reference substance: National Institute for the Control of Pharmaceutical and Biological Products; Quandu Zhong Capsule: Jiangxi Puzheng Pharmaceutical...

Embodiment 2

[0063] Example 2: Establishment of fingerprints of traditional Chinese medicine Eucommia ulmoides.

[0064] (1) Instruments and reagents: High-performance liquid chromatography: Shimadzu LC-10ATvp high-performance liquid chromatography (SPD-M10Avp detector, CLASS-VP software); CNC ultrasonic cleaner: KQ-250DB, Kunshan Ultrasonic Instrument Co., Ltd.; 1 / 100,000 balance: Shimadzu AUW220; 1 / 10,000 balance: AB104-N type, manufacturer: Mettler-Toledo.

[0065] Acetonitrile: Chemical Branch of Shandong Yuwang Experimental Co., Ltd.; Methanol: Shanghai Zhenxing Chemical Factory No. 1; Phosphoric acid (excellent grade): Tianjin Fine Chemicals Development Co., Ltd.; Potassium dihydrogen phosphate: Shantou Xilong Chemical Factory Co., Ltd.; pure water.

[0066] Chlorogenic acid reference substance: National Institute for the Control of Pharmaceutical and Biological Products.

[0067] (2) Preparation of reference solution.

[0068] Weigh the chlorogenic acid reference substance,...

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Abstract

The invention relates to a method for detecting the quality of a Chinese medicine eucommia preparation and belongs to the technical field of medicine quality control. The method comprises the following steps of: (1) preparing reference substance solution; (2) preparing test sample solution; (3) diluting gradually; (4) drawing a standard fingerprint graph by taking chlorogenic acid as a reference peak; and (5) controlling the quality of the fingerprint graph. Compared with the prior art, the method has the advantages that: the standard fingerprint graph is constructed by adopting efficient liquid phase, and quantified parameters are obtained by taking the characteristics of active ingredients of the eucommia as major through the fingerprint graph; the method is higher in precision and highin stability and repeatability; and the quality of the preparation can be controlled more comprehensively and effectively.

Description

technical field [0001] The invention belongs to the technical field of medicine quality control, and in particular relates to a fingerprint detection method of a traditional Chinese medicine eucommia preparation. Background technique [0002] Eucommia ulmoides is the dry bark of Eucommia ulmoids oliv., a plant in the Eucommia family. It was first recorded in "Shen Nong's Materia Medica". It is mostly used for hypertension, kidney deficiency, low back pain, and weakness of the waist and knees. Due to the easy availability of Eucommia resources, it has become a hot spot for today's medicinal development, and has achieved many achievements, such as Quandu Zhong Capsules, Duzhong Granules, Duzhong Flat Compressed Tablets, Duzhong Zhuanggu Pills, Duzhong Granules, etc. [0003] As a Chinese patent medicine, Eucommia preparations do not come from any single active ingredient, but are the result of the cooperation of multiple active ingredients. However, for Eucommia preparations...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 肖军平夏川川吴永忠李旭余宝平
Owner JIANGXI POZIN PHARMA
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