Spiral Hollow Fiber Tube Artificial Liver Bioreactor

Abstract

The invention discloses a spiral hollow fiber tube artificial liver bioreactor. A plurality of hollow fiber tubes are evenly packed in parallel in the center of the transparent cylindrical container. The inside of the hollow fiber tube is the inner cavity, and the outside of the hollow fiber tube is the outer cavity. The patient plasma / blood inlet and patient plasma / blood outlet of the inner cavity are respectively set. At both ends of the cylindrical container, the inlet of the hepatic cell culture solution and the outlet of the hepatic cell culture solution in the outer cavity are arranged side by side on the cylindrical surface of the cylindrical container. The plurality of hollow fiber tubes are a plurality of helical hollow fiber tubes, and the helix angle is not more than 45° and not less than 10°. The invention ensures that there is enough area for the hepatocytes to adhere to the wall and grow, and at the same time, the blood flow in the spiral tube will generate a secondary flow, which is conducive to the full mixing of blood and prevents a large amount of plasma protein from adhering to the tube wall to block the holes of the hollow fiber membrane. It is helpful for the detoxification and mass transfer of the hollow fiber, prolongs the supporting time of the artificial liver in vitro, and improves the therapeutic efficiency of the artificial liver.

Description

technical field [0001] The invention relates to an artificial liver bioreactor, in particular to a spiral hollow fiber tube artificial liver bioreactor. Background technique [0002] The bioreactor is the core device of the extracorporeal bioartificial liver support system. It is the place where exogenous liver cells exchange substances with the plasma / blood of patients with liver failure, and is the key part to play the role of artificial liver support. As a bioreactor, the following basic functions are required: two-way transmission of small and medium molecular substances, immune barrier of macromolecular substances such as immunoglobulin, protection of liver cell activity and function, certain capacity and easy expansion. [0003] At present, the existing bioreactors used in the artificial liver system are generally hollow fiber bioreactors, that is, a plurality of hollow fiber tubes are packaged in a cylindrical container, and the hollow fiber tube divides the container...

AI Technical Summary

Problems solved by technology

Hepatocytes are adherent cells, but generally the tubular shape of the hollow fiber bioreactor is a straight tube, which is not conducive to the adherent growth of hepatocytes cultured in the extratube cavity

In addition, when the patient's plasma / blood flows in the straight tube, the flow field is consistent, there will be no secondary flow phenomenon, and the plasma / blood and the external cavity cannot perform sufficient material exchange

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