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A nanoscale pumpkin extract containing inositol and its preparation method and application

An extract and nano-scale technology, which is applied to the nano-scale pumpkin extract containing inositol and the fields of its preparation and use, can solve the problems that the pharmacological effect cannot be fully attributed to the chemical composition, and the absorption and utilization are not easy.

Active Publication Date: 2011-11-30
上海诺金科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hao Cunjiang's research results show that the pharmacological effects of traditional Chinese medicine cannot be completely attributed to the unique chemical composition of the medicine, but are also closely related to the physical state of the medicine.
Pumpkin extract often obtains macromolecular functional molecules, which are not easy to be absorbed and utilized by the human body. At present, there is no research on its nanotechnology.

Method used

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  • A nanoscale pumpkin extract containing inositol and its preparation method and application
  • A nanoscale pumpkin extract containing inositol and its preparation method and application
  • A nanoscale pumpkin extract containing inositol and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Preparation of pumpkin extract containing inositol

[0018] 1) Weigh 1 kg of pumpkin, wash it, remove the stalk and pedicle of the pumpkin, cut into thin slices, place it in a pulverizer, pulverize it into a slurry, and spray dry to obtain pumpkin powder;

[0019] 2) Put the pumpkin powder in a stainless steel bucket, add 20L of distilled water, stir and extract at 40°C for 4 hours, centrifuge, add 10L of distilled water to the filter residue for extraction once, centrifuge to discard the residue, combine the two filtrates, and concentrate under reduced pressure to 1 / 1 of the original volume 30;

[0020] 3) Add acetic acid buffer solution with pH 4.2 and 2% phytase in the concentrated solution, perform enzymatic hydrolysis at 40°C for 2 hours, concentrate under reduced pressure to 1 / 5 volume, remove acetic acid, adjust pH to neutral, and obtain enzymatic hydrolysis solution ;

[0021] 4) The above enzymolysis solution was subjected to column chromatography t...

Embodiment 2

[0022] Example 2 Preparation of pumpkin extract containing inositol

[0023] The extract was prepared according to the scheme of Example 1, except that the pumpkin pretreatment was crushed and then spray-dried instead of spray-dried, that is, the wet pumpkin crushed material was directly used for subsequent extraction.

Embodiment 3

[0024] Example 3 Preparation of Pumpkin Extract Containing Inositol

[0025] The extract was prepared according to the scheme of Example 2, except that the amount of extractant added was changed from 20L for the first time and 10L for the second time to 7L for the first time and 3L for the second time.

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Abstract

The invention discloses a nano-sized inositol-containing cucurbita moschata duch extract, a preparation method thereof, and an application thereof. The cucurbita moschata duch extract contains 3% to 5% of total inositols, and has an average particle size of 300nm to 500nm. The preparation method comprises steps that: cucurbita moschata duch is extracted by using an extracting agent; inositol derivatives are enzymolyzed by using phytase, such that inositol monomers are released; through ion exchange resin separation, a cucurbita moschata duch inositol extract containing inositol monomers and inositol derivatives is obtained; through a high-energy ball milling method, the extract is prepared into a nano-sized cucurbita moschata duch extract with a proper particle size. As a result of experiments, the nano-sized inositol-containing cucurbita moschata duch extract has a good hypoglycemic auxiliary effect, and can be applied in preparations of diabetes mellitus novel medicines and various healthcare preparations.

Description

technical field [0001] The invention relates to a nanoscale pumpkin extract containing inositol and its preparation method and application. Background technique [0002] Pumpkin, scientific name Cucurbita moschata Duch, alias pumpkin, meal melon, etc., is Cucurbitaceae. Pumpkin not only has very high nutritional value, but also has extremely high medicinal value, among which the most well-known medicinal and health functions are anti-diabetic. In recent years, more and more attention has been paid to the research on the functional factors of pumpkin and the development of corresponding functional foods. According to research reports, the polysaccharides and inositol contained in pumpkin are the main effective substances for anti-diabetes. [0003] Inositol is a new type of specific molecule discovered in recent years to develop and treat diabetes. It is an important and in short supply pharmaceutical additive and biochemical raw material. It has the effect similar to vitami...

Claims

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Application Information

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IPC IPC(8): A61K36/42A61K31/047A61K9/14A61P3/10A23L1/29A23L33/00
Inventor 刘华奇陈丹青吴芬宏赵萍李彦娜夏涛
Owner 上海诺金科生物科技有限公司
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