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Making and sterilizing method of polypropylene plastic infusion bottle

A large infusion solution and polypropylene granule technology, which is applied in the field of pharmaceutical packaging, can solve the problems of non-compliance with clean production requirements, increase the space of clean areas, increase production costs, etc., and achieve energy saving and water vapor consumption, convenient operation, and high-temperature degradation The effect of reducing impurities

Active Publication Date: 2011-11-23
SHIJIAZHUANG NO 4 PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] The existing production technology status is: 1. The bottle making process is divided into two steps of injection molding and blow molding, and it needs to be placed and stored for a long time in the middle. This will increase the probability of pollution, and the second is to increase the space of the clean area and increase the manufacturing cost.
2 The sterilization temperature is low, the standard sterilization time is short, and the sterilization guarantee value is poor
3 If the sterilization temperature is increased, the plastic bottle will be deformed and waste products will be increased
4 If you want not to deform, you have to increase the thickness of the bottle, which greatly increases the amount of materials used, which does not meet the requirements of clean production and increases the production cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1) Injection blow molding process: Melt and extrude 19.8g of pharmaceutical-grade polypropylene particles at high temperature to make a preform, and blow it with clean high-pressure air to make an empty bottle with a full volume of 670mlml;

[0038] Among them, the injection molding control method is five-speed five-pressure method, and the specific five-level pressure is: 12MPa for level 1 to level 3, 11MPa for level 4, and 9.5MPa for level 5;

[0039] Stretch pre-blowing before blow molding;

[0040] 2) Washing, filling and sealing process: wash the bottle body with clean negative ion air, then fill the liquid with 0.9% sodium chloride, control the temperature of the liquid to be filled at 70°C, fill 510ml, and seal the bottle after filling;

[0041] 3) High-temperature sterilization process: put the canned medicine bottle into an autoclave, control the sterilization internal pressure to 0.30 MPa, and sterilize at 119° C.; sterilize for 15 minutes.

Embodiment 2

[0043] 1) Injection blow molding process: Melt and extrude 12.5g of pharmaceutical-grade polypropylene particles at high temperature to make a preform, and blow it with clean high-pressure air to make an empty bottle with a full volume of 370ml;

[0044] Among them, the injection molding control method is five-speed five-pressure method, and the specific five pressures are: 11MPa for grades 1 to 3, 4.7MPa for grade 4, and 3.6MPa for grade 5; the five speeds are: 38% for grades 1 to 3, and 36% for grades 4 and 5.

[0045] Stretch pre-blowing before blow molding;

[0046] 2) Washing, filling and sealing process: wash the bottle body with clean negative ion air, and then fill the liquid containing 0.9% sodium chloride, control the temperature of the liquid to be filled at 65°C, the filling volume is 256ml, and seal the bottle after filling;

[0047] 3) High-temperature sterilization process: put the canned medicine bottle into the high-pressure sterilization box, control the ster...

Embodiment 3

[0049] 1) Injection blow molding process: Melt and extrude 8.2g of pharmaceutical-grade polypropylene particles at high temperature to make a preform, and blow it with clean high-pressure air to make an empty bottle with a full volume of 193ml;

[0050] Among them, the injection molding control method is the five-speed five-pressure method, and the specific five pressures are: 12MPa for grades 1 to 3, 4.5MPa for grade 4, and 3.5MPa for grade 5; the five-speed is 40% for grades 1 to 3, and 30% for grades 4 and 5.

[0051] Stretch pre-blowing before blow molding;

[0052] 2) Washing, filling and sealing process: wash the bottle body with clean negative ion air, then fill the assembled 0.9% sodium chloride infusion liquid, control the temperature of the liquid to be filled at 65°C, and the filling volume is 103ml. cover;

[0053] 3) High-temperature sterilization process: put the canned medicine bottle into the high-pressure sterilization box, control the sterilization internal ...

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Abstract

The invention relates to a making and sterilizing method of a polypropylene plastic infusion bottle, comprising the following steps of: (1) an injection molding and blow molding process: melting medicinal-grade polypropylene granules at high temperature, extruding to make a bottle blank, blowing into a medicine bottle by using clean high-pressure air, wherein a blow molding control mode is a five-speed five-pressure method, and stretching foreblow is carried out before blow molding shaping; (2) a cleaning, filing and sealing process: cleaning the medicine bottle in a pumping way by using clean negative ion air, then filing medicine-containing liquid, controlling the medicine-containing liquid to be filled at the constant temperature of 50-75 DEG C, filling and then sealing a cover; (3) a high-temperature sterilizing process: placing the completely-filled and cover-sealed medicine bottle into a high-pressure sterilizing tank for sterilization, wherein inner pressure is controlled between 0.20 MPa and 0.35 MPa, sterilization temperature is 117-121 DEG C, and sterilization time is 20-12 minutes.

Description

Technical field: [0001] The invention relates to a medicine packaging method, in particular to a polypropylene plastic bottle large infusion bottle manufacturing technology and a sterilization method. Background technique: [0002] Polypropylene [0003] English name: Polypropylene [0004] Molecular formula: [C3H6]n [0005] Abbreviation: PP, [0006] Polypropylene plastic is a thermoplastic resin obtained by polymerizing propylene. There are three configurations: isotactic, atactic and syndiotactic, and industrial products use isotactic as the main component. Polypropylene also includes copolymers of propylene and a small amount of ethylene. Usually translucent colorless solid, odorless and non-toxic. Due to its regular structure and high crystallization, its melting point is as high as 167°C. It is heat-resistant and its products can be sterilized by steam. With a density of 0.90g / cm3, it is the lightest general-purpose plastic. Corrosion resistance, tensile stren...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/05B29C49/06B29C45/76B67C7/00A61L2/02B65B55/02
Inventor 王立江任玉新王保华封建森
Owner SHIJIAZHUANG NO 4 PHARMA
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