Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Degradable coronary stent and manufacturing method thereof

A technology of coronary artery and matrix, applied in the field of degradable coronary stent and its preparation

Inactive Publication Date: 2011-11-02
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
View PDF5 Cites 70 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, from the current experimental results, the degradation rate of the new alloy in simulated body fluids is not substantially improved compared with that of pure iron, and it still cannot meet the requirements for the material degradation rate of vascular stents.
Since the degradation process of iron-based alloys is accompanied by two processes of oxygen absorption corrosion and hydrogen evolution corrosion, and for iron-based alloys in a specific solution, the highest oxygen absorption corrosion rate is a fixed value, so the increase of oxygen absorption corrosion rate can be improved. Pathway to degradation rate of iron-based alloys elusive

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] First, PLGA with a weight ratio of 85:15 of lactic acid and glycolic acid and a molecular weight of 100,000 was dissolved in ethyl acetate at a concentration of 1w / v%, and then a PLGA coating was prepared on the surface of pure iron by spraying, with a thickness of It is 23.4μm and dried in air for 24 hours.

[0022] The degradation rate of the pure iron sample coated with PLGA coating was 0.0405mm / year measured by weight loss method after immersion in 37oC physiological saline for 28 days, which was 4 times the degradation rate of the uncoated pure iron sample.

Embodiment 2

[0024] First, PLA with a molecular weight of 80,000 was dissolved in acetone at a concentration of 5w / v%, and then a PLA coating was prepared on the surface of the Fe-30Mn alloy by spraying with a thickness of 13.7 μm. Air dry for 12 hours.

[0025] The degradation rate of the Fe-30Mn alloy sample coated with PLA coating was 0.0384mm / year, which was 3.8 times that of the uncoated Fe-30Mn alloy sample after immersion in 37oC physiological saline for 28 days.

Embodiment 3

[0027] First, PLGA with a weight ratio of 60:40 of lactic acid and glycolic acid and a molecular weight of 70,000 was dissolved in chloroform at a concentration of 5w / v%, and then the PLGA coating was prepared on the surface of Fe-30Mn-1C alloy by dip coating. The layer, with a thickness of 21.9 μm, was dried in vacuum for 12 hours.

[0028] The degradation rate of the Fe-30Mn-1C alloy sample coated with PLGA coating was 0.0334mm / year measured by the weight loss method after immersion in 37oC physiological saline for 28 days, which is the degradation rate of the uncoated Fe-30Mn-1C alloy sample 3.3 times.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention provides a degradable coronary stent, which is characterized in that an iron-based material is taken as a matrix, and the surface of the matrix is covered with a degradable macromolecule coating; and components in the degradable macromolecule coating contain ester bonds (-COO-). The manufacturing method comprises the following concrete steps: a macromolecule material containing the ester bonds is dissolved in an organic solvent; and a dip-coating or spray-coating method is utilized to coat the mixture on the surface of an iron-based alloyed matrix, wherein the coating thickness is 1-40mu m. The degradable coronary stent is used for enhancing the degradation / corrosion speed of the iron-based coronary stent and improving the biocompatibility of the iron-based alloy, and is beneficial to rapid endothelialisation of endothelial cells on the surface of the stent. The method is simple and is convention to operate.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to the field of coronary stents for interventional treatment of coronary heart disease, and particularly provides a degradable coronary stent and a preparation method thereof. Background technique [0002] In recent years, interventional therapy has become the mainstream treatment for coronary heart disease, and coronary stent implantation is an important part of interventional therapy. At present, permanent stents are mainly used clinically, and the materials of permanent stents are mainly non-degradable 316L stainless steel and Co-Cr alloy. Although permanent stents solve the acute closure of vessels and long-term thrombosis after percutaneous transluminal coronary angioplasty (PTCA), problems such as subacute thrombosis and in-stent restenosis follow after stent implantation , and patients implanted with stents need to take anti-platelet aggregation drugs for a long time. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/02A61F2/82
Inventor 吴敬尧谭丽丽杨柯张炳春
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com