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Sodium humate skin external preparation for promoting wound healing

A technology of sodium humate and external preparations, applied in the direction of medical preparations of non-active ingredients, drug combinations, aerosol delivery, etc., to achieve the effects of shortening wound healing time, safe and effective wound healing, and large area

Inactive Publication Date: 2011-10-26
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report that sodium humate has been made into external preparations to promote wound healing.

Method used

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  • Sodium humate skin external preparation for promoting wound healing
  • Sodium humate skin external preparation for promoting wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 gel

[0031] Sprinkle 1g of carbomer into 60ml of purified water, after it swells naturally, add 1g of sodium humate dissolved in 10ml of purified water, 5ml of glycerin, 0.1g of ethylparaben, and add 2g of triethanolamine dropwise under constant stirring , add purified water to 100g, continue to stir until a brownish-black to black paste is obtained, and then pack it.

Embodiment 2

[0032] The preparation of embodiment 2 gel

[0033] Sprinkle 5g of sodium carboxymethylcellulose into 60ml of purified water. After it swells naturally, add 1g of sodium humate dissolved in 10ml of purified water, 5ml of glycerin, 0.1g of ethylparaben, and add purified water to 100g. Continue to stir until a brown-black to black paste is formed, and then pack it.

Embodiment 3

[0034] The preparation of embodiment 3 gel

[0035] Sprinkle 10g of chitosan into 60ml of purified water, and after it swells naturally, add 0.5g of sodium humate dissolved in 10ml of purified water, 5ml of propylene glycol, and 0.1g of sodium benzoate, add purified water to 100g, and continue stirring until it condenses Brown-black to black paste, ready to pack.

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Abstract

The invention discloses a sodium humate skin external preparation for promoting wound healing, which is a gel formulation, a film formulation, a film-forming formulation or an ointment formulation of sodium humate in addition with pharmaceutically-acceptable adjuvant materials. In terms of the mass fraction, the content of sodium humate is 0.1% to 20%. The sodium humate skin external preparation disclosed by the invention has strong effects of relieving the inflammation, reducing the exudation, promoting the regeneration of capillary vessels and increasing the generation of collagen, and can significantly reduce the time of wound healing and promote wound healing. The application range of sodium humate in the medicine field is increased, and the blank of sodium humate skin external preparations is filled in. The sodium humate skin external preparation is available in various forms for external application, such as a gel, a film, a film-forming agent and an ointment. The sodium humate skin external preparation has the characteristics of relatively-definite components, quick onset of action, stable property and accurate quality control, and is convenient to be used in the clinic and selected by patients.

Description

technical field [0001] The invention belongs to the technical field of drugs for promoting wound healing, and relates to an external preparation of sodium humate for promoting wound healing. Background technique [0002] Trauma is a common surgical disease. Surgery, trauma, infection, drug and immune response, and some unconventional factors such as fire, burn, scald, etc. can damage the body tissue. The methods currently used to promote wound healing mainly include: genetic engineering drugs (such as basic fibroblast factor), laser, bioengineering materials (such as chitin), drugs (such as Kangfuxin), etc. Among them, laser treatment requires special equipment and operators, and is easy to damage normal skin; commonly used effective drugs dedicated to promoting wound healing are less, inconvenient to store and carry (biological agents need to be stored at low temperature), improper dosage forms (mostly solutions, not easy to adhere to the skin) ) and other deficiencies, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/02A61K9/00A61K9/06A61K47/32A61K47/34A61K47/36A61K47/38A61K47/44A61P17/02A61K35/10
Inventor 张爱军车晓侠闫志勇王志东罗红李兴华
Owner XI AN JIAOTONG UNIV
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