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Traditional Chinese drug composition for treating pelvic inflammatory disease, preparation method, application thereof

A composition and technology for pelvic inflammatory disease, applied in the field of traditional Chinese medicine composition for treating pelvic inflammatory disease and its preparation, can solve problems such as difficulty in antibiotics, lack of adhesion-relieving and pain-relieving effects of antibiotics, poor effect of fibrous tissue and connective tissue, etc.

Inactive Publication Date: 2011-09-21
NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current Western medicine treatment for this disease mainly starts from two aspects: that is, the application of antibiotics, which aims to eliminate the cause of pathogenic microorganisms, but for chronic pelvic inflammation, due to tissue adhesions and local circulation disorders, it is difficult for antibiotics to penetrate into the local area. It has poor effect on eliminating fibrous tissue and connective tissue infiltrated by inflammation, and antibiotics do not have the effect of relieving adhesion and analgesia, so chronic pelvic inflammatory disease is treated with antibiotics alone, and the curative effect is not satisfactory; in addition, the application of hormones, α-chymotrypsin , placental tissue fluid to reduce inflammation, anti-fibrosis and granulation tissue hyperplasia, and enhance the body's immunity, all have certain limitations and side effects
There are many Chinese patent medicines in the treatment of pelvic inflammatory disease in traditional Chinese medicine, but most of them have unstable curative effect, low cure rate and easy recurrence

Method used

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  • Traditional Chinese drug composition for treating pelvic inflammatory disease, preparation method, application thereof
  • Traditional Chinese drug composition for treating pelvic inflammatory disease, preparation method, application thereof
  • Traditional Chinese drug composition for treating pelvic inflammatory disease, preparation method, application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Preparation of capsules.

[0042] According to the raw material ratio in Table 1 and the conventional method of capsule dosage form, the capsule is prepared, and the specific method is as follows:

[0043] Take 10 parts of zedoary turmeric and 25 parts of angelica, and use supercritical CO 2 Extract for 1 hour, extract temperature 20℃, pressure 20MPa, entrainer 95% ethanol, get supercritical extract, adopt saturated aqueous solution method to clathrate β-cyclodextrin, stir continuously for 3 hours under 30℃ heat preservation condition, stirring speed is 80 rpm, refrigerated for 24 hours, filtered with suction, dried at 40°C to obtain β-cyclodextrin inclusion compound, save it separately;

[0044] The above supercritical CO 2 After the extraction process, the medicinal residue and 6 parts of safflower, 40 parts of motherwort, 6 parts of Corydalis, 10 parts of Radix Aconiti, 10 parts of Rehmannia glutinosa, 20 parts of Polygonum cuspidatum Store 10 parts and 20 parts...

Embodiment 2

[0045] Example 2: Preparation of granules.

[0046] Prepare granules according to the raw material ratio in Table 1 and the conventional method of granule dosage form, and the specific method is as follows:

[0047] Take 15 parts of zedoary turmeric and 20 parts of angelica, and use supercritical CO 2 Extract for 2h, extract temperature 40℃, pressure 30MPa, entrainer is 95% ethanol, get supercritical extract, adopt saturated aqueous solution method to clathrate β-cyclodextrin, keep stirring at 50℃ for 4 hours, stirring speed is 100 rpm, refrigerated for 36 hours, suction filtered, dried at 45°C, to obtain β-cyclodextrin inclusion compound, save it separately;

[0048] The above supercritical CO 2 After the extraction process, the dregs and 8 parts of safflower, 30 parts of motherwort, 8 parts of Corydalis, 8 parts of Radix Aquilinum, 15 parts of Radix Rehmanniae, 15 parts of Polygonum Cuspidatum Store 15 parts and 15 parts of Plantago Seed with 8 herbs, add water to decoct twice, ad...

Embodiment 3

[0049] Example 3: Preparation of tablets.

[0050] According to the raw material ratio in Table 1 and the conventional method of tablet dosage form, the tablet is prepared. The specific method is as follows:

[0051] Take 20 parts of zedoary turmeric and 15 parts of angelica, and use supercritical CO 2 Extraction for 3h, extraction temperature 60℃, pressure 40MPa, entrainer 95% ethanol, to obtain supercritical extract, adopt saturated aqueous solution method to clathrate β-cyclodextrin, and stir continuously for 5 hours under the condition of heat preservation at 70℃, the stirring speed is 120 rpm, refrigerated for 48 hours, suction filtered, dried at 50°C, β-cyclodextrin inclusion compound, save separately;

[0052] The above supercritical CO 2 After the extraction process, the dregs and safflower 10 parts, motherwort 20 parts, corydalis 10 parts, black medicine 6 parts, rehmannia glutinosa 20 parts, polygonum cuspidatum 10 parts, Storing 20 parts and 10 parts of Plantago Seed with...

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PUM

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Abstract

The invention discloses a traditional Chinese drug composition for treating pelvic inflammatory disease (PID). The traditional Chinese drug composition is prepared from the following raw materials, by weight, 10-20 parts of blue turmeric rhizome, 15-25 parts of Chinese angelica, 6-10 parts of safflower, 20-40 parts of common motherwort herb, 6-10 parts of yanhusuo tuber, 6-10 parts of combined spicebush root, 10-20 parts of aahesive rehmannia root tuber, 10-20 parts of giant knotweed rhizome, 10-20 parts of common knotweed herb, 10-20 parts of asiatic plantain seed. The invention further discloses a preparation method for preparing the traditional Chinese drug composition, and an application of the traditional Chinese drug composition. The traditional Chinese drug composition provided by the present invention has advantages of activating blood and dissolving stasis, clearing heat and removing dampness, and can be used for treating the PID.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for treating pelvic inflammatory disease, and a preparation method and application thereof. Background technique [0002] Pelvic inflammatory disease refers to the inflammatory damage of the female upper genital tract and its adjacent structures. Acute pelvic inflammatory disease fails to be treated, and the mistreatment continues to become chronic pelvic inflammatory disease. Pelvic inflammatory disease is a common and frequently-occurring disease in clinical gynecology, and has a high recurrence rate. In the United States, there are about 1 million patients with pelvic inflammatory disease each year, of which about 250,000 women are hospitalized for pelvic inflammatory disease. About a quarter of patients with pelvic inflammatory disease have repeated attacks and form chronic pelvic inflammatory disease. The...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/00A61K47/48A61P15/00
Inventor 陈军霞卞凌
Owner NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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