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A traditional Chinese medicine composition for treating chronic atrophic gastritis and intestinal metaplasia, its preparation method and application

A technology of atrophic gastritis and composition, which is applied in the field of traditional Chinese medicine composition and its preparation for the treatment of chronic atrophic gastritis and intestinal metaplasia, which can solve the problems of lack of unified, standardized and standard treatment plan, experience and different prescriptions, etc. To achieve the effect of protecting gastric mucosa, rational syndrome differentiation and accurate compatibility

Active Publication Date: 2018-09-04
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The research results of traditional Chinese medicine show that traditional Chinese medicine has accumulated rich experience in the treatment of CAG and IM. However, the experience and prescriptions of current treatment methods are different, and there is a lack of unified, standardized and standard treatment plan.

Method used

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  • A traditional Chinese medicine composition for treating chronic atrophic gastritis and intestinal metaplasia, its preparation method and application
  • A traditional Chinese medicine composition for treating chronic atrophic gastritis and intestinal metaplasia, its preparation method and application
  • A traditional Chinese medicine composition for treating chronic atrophic gastritis and intestinal metaplasia, its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: the preparation of capsule

[0035] According to the raw material ratio in Table 1 and the conventional method of capsule dosage form, it is prepared into capsules, and the specific methods are as follows:

[0036] Take the mica stone and break it into pieces, add water and decoct for 30 minutes, the amount of water added is 3 times the weight of the medicinal materials, then add Codonopsis pilosula, fried Atractylodes macrocephala, French pinellia, Poria cocos, tangerine peel, Hedyotis diffusa, Curcuma, and turmeric medicinal materials, add water and decoct Boil twice, add water for the first time to 8 times the weight of the medicinal material, decoct for 1 hour, add water for the second time to 6 times the weight of the medicinal material, decoct for 1 hour, combine the decoction, and when concentrated to 65 ° C, the relative density is 1.15, Add ethanol so that the volume percentage of alcohol content reaches 75%, stir, stand still, filter, and the rel...

Embodiment 2

[0037] Embodiment 2: the preparation of granule

[0038] According to the ratio of raw materials in Table 1 and the conventional method of granule dosage form, it is prepared into granules, and the specific method is as follows:

[0039] Take the mica stone and break it into pieces, add water and decoct for 30 minutes, the amount of water added is 5 times the weight of the medicinal materials, then add Codonopsis pilosula, fried Atractylodes macrocephala, Pinellia chinensis, Poria cocos, tangerine peel, Hedyotis diffusa, Curcuma, and turmeric medicinal materials, add water and decoct Boil twice, add water 10 times the weight of the medicinal material for the first time, decoct for 1.5h, add water for the second time 8 times the weight of the medicinal material, decoct for 1.5h, combine the decoction, and when concentrated to 65°C, the relative density is 1.20, add ethanol so that the volume percentage of the alcohol content reaches 80%, stir, stand still, filter, and the relat...

Embodiment 3

[0040] Embodiment 3: the preparation of tablet

[0041] Prepare by the raw material proportioning of table 1 and tablet dosage form conventional method, be prepared into tablet, concrete method is as follows:

[0042] Take the mica stone and break it into pieces, add water and decoct for 30 minutes, the amount of water added is 4 times the weight of the medicinal materials, then add Codonopsis pilosula, fried Atractylodes macrocephala, French pinellia, Poria cocos, tangerine peel, Hedyotis diffusa, Curcuma, and turmeric medicinal materials, add water and decoct Boil twice, add water for the first time to 12 times the weight of the medicinal material, decoct for 2 hours, add water for the second time to 10 times the weight of the medicinal material, decoct for 2 hours, combine the decoction, and when concentrated to 65 ° C, the relative density is 1.20, Add ethanol so that the volume percentage of the alcohol content reaches 85%, stir, stand still, filter, and the relative dens...

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Abstract

The invention belongs to the field of pharmaceutical preparation, particularly discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis and intestinal metaplasia and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following raw materials: codonopsis pilosula, stir-fried rhizoma atractylodis macrocephalae, rhizoma pinellinae praeparata, poria cocos, pericarpium citri reticulatae, hedyotis diffusa, mica atba, rhizoma curcumae and radix curcumae; the preparation method comprises the steps of water extraction, alcohol precipitation, spray drying and addition of auxiliary materials, therefore various preparations are obtained, and the functions of invigorating spleen, supplementing qi, regulating qi-flowing for harmonizing stomach, and improving and resisting gastric mucosal atrophy and intestinal metaplasia are achieved, besides, the invention further discloses the application of the traditional Chinese medicine composition to preparation of drugs used for treating chronic atrophic gastritis and intestinal metaplasia.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating chronic atrophic gastritis and intestinal metaplasia, a preparation method and application thereof. Background technique [0002] Chronic atrophic gastritis (CAG) is one of the most common diseases of the digestive system. The incidence rate in my country is 7.5-13.8%. Chronic atrophic gastritis with intestinal metaplasia (IM) is closely related to the incidence of gastric cancer. It was recognized by WHO experts in 1980. The tissue was defined as gastric precancerous lesions, and its cancerous rate was 2.55-7.46%. There are no specific treatment measures and methods for CAG and IM so far. Modern medicine mostly adopts ① completely eradicate HP infection; ② strengthen the barrier function and promote epithelial growth drugs; ③ promote gastrointestinal motility and reduce intestinal fluid reflu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P1/04A61P1/00A61K33/06
Inventor 朱方石徐婷婷田耀洲
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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