Graphene-based nano-pore monomolecular sensor and medium identification method thereof

Abstract

The invention discloses a graphene-based nano-pore monomolecular sensor and a medium identification method thereof. In the graphene-based nano-pore monomolecular sensor, conductive single-layer or multi-layer graphene is used as a radial electrode; the graphene electrode is clamped inside an insulation layer, so the structural strength is enhanced; a nano-pore channel is formed on the insulation layer; the cathode and the anode of the radial electrode are located at both ends of the nano-pore channel in the radial direction respectively; and an axial electrode is arranged along the axial direction of the nano-pore channel. During medium identification, both ends of the nano pore are connected with a fluid pool unit, and voltage is exerted between the axial electrode and the radial electrode respectively; and when a medium passes through the nano pore, the medium in the channel is identified by measuring weak change of axial and radial current. The sensor has a simple structure; meanwhile, by comprehensive analysis of the radial current and the axial current, higher sensitivity and identification rate can be obtained; moreover, due to analysis, the pore-passing medium can be detected and the pore-passing state is analyzed according to the tested medium; therefore, the property of the medium can be analyzed.

Description

technical field [0001] The invention relates to the technical field of nanofluid detection, in particular to a graphene-based nanopore single-molecule sensor and a method for using the sensor to identify a medium to be measured. Background technique [0002] Biomolecular sensors using nanochannel technology can not only perform DNA sequencing, but also detect bacteria, protein molecules, and detect antigen-antibody reactions, thus having broad application prospects for disease detection and drug screening. [0003] When biomolecules pass through the nanopore channel, the ion current in the nanochannel will change. This is due to the different charges and structures on the surface of the biomolecules, resulting in different changes in the ion current generated when the molecule passes through the hole, so it is unique. Different biomolecules can thus be identified. This is the principle of current existing nanopore technology. [0004] The principle of the nanopore sensor i...

AI Technical Summary

Problems solved by technology

However, the current current detection method is to apply a voltage at the axial end of the nanopore, which affects the resolution of the sensor.

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