Preparation method of Xiaoyao powder antidepressant extract

Abstract

The invention provides a preparation method of an ease powder antidepressant extractive, which comprises the steps of: weighing radix bupleuri, angelica sinensis, poria cocos, white paeony root, bighead atractylodes rhizome, radix glycyrrhizae preparata, mentha haplocalyx and ginger according to the weight preparation of the prescription of the ease powder; and reflowing and extracting by adding ethyl acetate, filtering, and drying to obtain the ease powder extractive. Compared with the ease powder compound, the ease powder antidepressant extractive is relatively clear and definite in chemical constituents, stable in technology, controllable in quality, lower in dosage, higher in medicine compliance, and convenient to store and transport. Compared with the patent application 201010110283.7, the ease powder antidepressant extractive is equal in antidepressant activity, simplified in technology, observably short in production cost and time, and green and environment-friendly in the use of dissolvent, and convenient to realize the industrialize most importantly. The analysis shows that the extractive mainly comprises the chemical constituents such as ligustilide, butenolide I, butenolide II, butenolide III, palmitic acid and the like. The preparation method is simple in technology, and is controllable in extractive quantity; and the dissolvent is safe to a human body, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine compound extract, in particular to a preparation method of a Xiaoyao powder antidepressant extract. Background technique [0002] Depression is a common mental illness characterized by high morbidity, relapse and disability. According to the prediction of WHO: by 2020, single depression will become the second most disabling disease, and its harm has attracted more and more attention from the medical and health circles. [0003] Xiaoyao San is a classic prescription with a history of nearly a thousand years of application. Modern clinical and pharmacological studies have confirmed that it has obvious antidepressant effects, and no toxic side effects have been found. Although there are many dosage forms such as powders, pills, concentrated pills, and granules, these medicines all use medicinal materials as raw materials. After simple processing, quality control is difficult...

AI Technical Summary

Problems solved by technology

Although there are various dosage forms such as powders, pills, concentrated pills, granules, etc., these medicines all use medicinal materials as raw materials, are simply processed, have difficulties in quality control, many ineffective ingredients, large dosages, and poor compliance.

[0004] In the early stage, our research group applied for the disclosure of an antidepressant effective part of Xiaoyao powder and its extraction method (application number 201010110283.7). Although it can solve the above problems, it has complex process, high production cost and long production cycle. The use of solvents is less safe and difficult to realize industrial production

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