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Ceramide dispersion and method for producing same

一种神经酰胺、制造方法的技术，应用在化学仪器和方法、非有效成分的医用配制品、含有效成分的医用配制品等方向，能够解决难以确保经时稳定性、损害安全性、可用性、稳定分散经时稳定性等问题

Inactive Publication Date: 2011-08-24
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in order to make ceramide transparent and soluble, it is necessary to mix a large amount of surfactant, which may impair safety and usability.
On the other hand, when the amount of the surfactant is reduced in order to obtain excellent usability, it often forms a cloudy or translucent milky state, and the ceramide cannot be made transparent and soluble. However, separation or creaming occurs, and it may be difficult to secure sufficient stability over time.
[0008] As described above, the present situation is that, even with these technologies, it is not possible to obtain a ceramide dispersion capable of stably dispersing ceramide and having excellent stability over time.

Method used

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  • Ceramide dispersion and method for producing same
  • Ceramide dispersion and method for producing same
  • Ceramide dispersion and method for producing same

Examples

Experimental program
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Effect test

preparation example Construction

[0220] When micro-mixture is used in the preparation of emulsion with small particle size as one of the microchemical processes, due to the low energy and low heat generation, compared with the usual stirring emulsification dispersion method and high-pressure homogenizer emulsification dispersion, it is easy to obtain uniform particle size, A good emulsion or dispersion with excellent storage stability. It is the best method for emulsification containing natural ingredients that are easily deteriorated by heat.

[0221] The outline of the method of emulsifying or dispersing using a micro mixer is to divide the water phase and the oil phase into minute spaces, and to make the respective minute spaces contact or collide with each other. This is different from the method of dividing only one part into a small space and the other in bulk, and is obviously different from the membrane emulsification method and the microchannel emulsification method. In fact, only one part is divided...

Embodiment 1

[0276] The components described in the following oil phase liquid 1 composition were stirred at room temperature for 1 hour to prepare oil phase liquid 1.

[0277]

specific example 1-10

[0278] Ceramide 3B [natural ceramide, specific examples 1-10] 0.9 parts

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PUM

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Abstract

A ceramide dispersion containing: (1) ceramide-containing particles having a volume average particle diameter of not less than 1 nm but not more than 100 nm, which contain a ceramide and are dispersed as oil phase components in a water phase; and (2) a fatty acid component composed of at least one of a fatty acid having a melting point of not more than 30 DEG C and a fatty acid salt. In the ceramide dispersion, a nonionic surfactant is contained in an amount of 0 or not more than 0.1 times the total mass of the ceramide, and an ionic surfactant other than the fatty acid component is contained in an amount of 0 or less than 0.05 times the total mass of the ceramide. The ceramide dispersion has a pH of not less than 6 but not more than 8.

Description

technical field [0001] The invention relates to a ceramide dispersion and a manufacturing method thereof. Background technique [0002] Ceramides exist in the stratum corneum of the skin and play an important role in building a lipid barrier necessary for moisture retention and maintaining moisture. Ceramides located in the stratum corneum are substances produced by decomposing cerebrosides with an enzyme called cerebrosidase. It is known that a part of ceramide is converted into phytosphingosine and sphingosine by an enzyme called ceramidase, and is important as a regulator of cell proliferation and differentiation. There are 6 different types of ceramides in human skin, and they have different functions. [0003] However, since ceramides are highly crystalline substances, have low solubility in other oils, and crystallize at low temperatures, it is difficult to secure stability when blending them into cosmetics. In addition, although the aqueous ceramide dispersion can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/00A61K8/36A61K8/37A61K8/68A61Q19/00C09K23/00C09K23/42C09K23/56
CPCA61K8/68A61K47/18A61Q19/00A61K8/062A61K8/06A61Q1/06A61K8/361A61K9/1075A61Q1/02A61K2800/21A61K9/0014A61Q17/04A61P17/00A61K8/04B01J13/00B01J13/02
Inventor 芹泽慎一郎森久容田代朋子中村善贞荒河纯
Owner FUJIFILM CORP
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