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Andrographolide and berberine combination and application thereof

A technology of andrographolide and berberine, which is applied in directions such as drug combination, medical preparations containing active ingredients, metabolic diseases, etc., can solve the problems such as no reports on the combination of andrographolide and berberine, unclear mechanism, etc. , to avoid cancer drug resistance, reduce side effects, and improve the effect of lowering blood sugar

Inactive Publication Date: 2011-08-17
JINAN UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] (4) A large number of studies have shown that the reduction of IL-6 secretion level in tumor cells can improve the cachexia caused by tumors, and the mechanism is still unclear
[0023] But there is no report on the combination of andrographolide and berberine

Method used

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  • Andrographolide and berberine combination and application thereof
  • Andrographolide and berberine combination and application thereof
  • Andrographolide and berberine combination and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Add andrographolide (350 g, 1 mol) into berberine hydrochloride (4075 g, 10 mol), mix well, add 800 g of medicinal starch, etc., and press it into 5000 tablets to obtain the andrographolide combination Tablets.

Embodiment 2

[0050] Add andrographolide (350 g, 1 mol) into berberine hydrochloride (815 g, 2 mol), mix well, add 200 g of distilled water and a mixture of 400 g of sucrose powder and dextrin (sucrose: dextrin =3:1), mixed into a soft material, extruded and sieved (12 mesh to 14 mesh) to make granules, dried at 60°C, granulated, and packed in plastic bags according to the equivalent of 4 g of andrographolide composition per bag , sealed, and the andrographolide composition granules are obtained.

Embodiment 3

[0052] Add 14-deoxyandrographolide (350 g, 1 mol) to berberine hydrochloride (407.5 g, 1 mol), mix well, pass through a 80-mesh sieve, mix with 150 g of starch, add 10% Stir 100 mL of starch slurry to make a soft material, pass through a 80-100 mesh sieve to granulate, dry at 60°C-70°C, granulate, add 0.2 g of magnesium stearate, mix evenly, pack 1,000 capsules, and obtain Andrographolide composition capsule.

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PUM

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Abstract

The invention discloses a medicinal combination which consists of andrographolide and derivative of the andrographolide and salt capable of being used in pharmacy, and berberine and derivative of berberine and salt capable of being used in pharmacy, and pharmaceutical adjuvant. The effect of the combination is better than that when the andrographolide or the berberine is independently used. The andrographolide and berberine combination has good effects of antibiosis, anti-inflammation, anti-tumor and blood sugar reduction.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its application, in particular to a composition of andrographolide and berberine and its application. Background technique [0002] Andrographolide is the main active ingredient in Andrographis paniculata, which is widely used in the treatment of various inflammatory diseases, including rheumatoid arthritis, pharyngitis, diarrhea, bacterial and viral infections, etc. In the past 30 years, andrographolide and its three derivatives Chuanhuning, Yanhuning and Lianbizhi have been widely used clinically in China. These drugs can alleviate clinical symptoms of inflammation, fever, bacterial and viral infectious diseases. These drugs are often referred to as "green antibiotics" because they are derived from natural Chinese medicines and have high efficacy. [0003] Although andrographolide has been widely used clinically, experiments have shown that it has no direct bactericidal effect (Singha et al.,...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K31/4375A61P31/04A61P29/00A61P35/00A61P3/10
Inventor 王玉强杜恩明徐立朋程潜任俊兰
Owner JINAN UNIVERSITY
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