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Oxytetracycline hydrochloride effervescent tablet for dairy cattle and preparation method thereof

A technology of oxytetracycline hydrochloride and effervescent tablets, which is applied to non-active ingredients medical preparations, pharmaceutical formulations, tetracycline active ingredients, etc., can solve the problem of small contact area between uterine mucosa and vagina, unsatisfactory treatment effect, poor solubility, etc. problem, to achieve the effect of good effect, quick effect and strong stability

Active Publication Date: 2012-05-30
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the treatment of vaginal and uterine diseases of dairy cows, vaginal and uterine perfusion are often used. However, due to the poor solubility of the above dosage forms and the small contact area with the uterine mucosa and vagina, the overall therapeutic effect is not ideal.

Method used

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  • Oxytetracycline hydrochloride effervescent tablet for dairy cattle and preparation method thereof
  • Oxytetracycline hydrochloride effervescent tablet for dairy cattle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Oxytetracycline hydrochloride effervescent tablets for dairy cows in this embodiment include the following components by weight: (according to the ratio of raw and auxiliary materials for 1000 oxytetracycline hydrochloride effervescent tablets):

[0030] Oxytetracycline Hydrochloride 3000g

[0031] Tartaric acid 4200g

[0032] Sodium bicarbonate 5800g

[0033] Polyvinylpyrrolidone 1500g

[0034] Polyethylene glycol 6000 800g

[0035] Anhydrous glucose 4600g

[0036] Magnesium Stearate 100g

[0037] Concrete preparation steps are:

[0038] (1) Dry oxytetracycline hydrochloride, tartaric acid, sodium bicarbonate, polyethylene glycol 6000, and anhydrous glucose, pass through an 80-mesh sieve, and set aside;

[0039] (2) Weigh each component in step (1), and mix them uniformly to form a powder mixture in an equal increment method;

[0040] (3) Dissolve polyvinylpyrrolidone in 95% ethanol solution, mix well, and set aside;

[0041] (4) Spray polyvinylpyrrolidone etha...

Embodiment 2

[0047] Oxytetracycline hydrochloride effervescent tablets for dairy cows in this embodiment include the following components by weight: (according to the ratio of raw and auxiliary materials for 1000 oxytetracycline hydrochloride effervescent tablets):

[0048] Oxytetracycline Hydrochloride 5000g

[0049] Tartaric acid 4200g

[0050] Sodium bicarbonate 5800g

[0051] Polyvinylpyrrolidone 1500g

[0052] Polyethylene glycol 6000 800g

[0053] Anhydrous glucose 2600g

[0054] Magnesium Stearate 100g

[0055] Concrete preparation steps are:

[0056] (1) Dry oxytetracycline hydrochloride, tartaric acid, sodium bicarbonate, polyethylene glycol 6000, and anhydrous glucose, pass through an 80-mesh sieve, and set aside;

[0057] (2) Weigh each component in step (1), and mix them uniformly to form a powder mixture in an equal increment method;

[0058] (3) Dissolve polyvinylpyrrolidone in 95% ethanol solution, mix well, and set aside;

[0059] (4) Spray polyvinylpyrrolidone etha...

Embodiment 3

[0065] Oxytetracycline hydrochloride effervescent tablets for dairy cows in this embodiment include the following components by weight: (according to the ratio of raw and auxiliary materials for 1000 oxytetracycline hydrochloride effervescent tablets):

[0066] Oxytetracycline Hydrochloride 8000g

[0067] Tartaric acid 3800g

[0068] Sodium bicarbonate 5200g

[0069]Polyvinylpyrrolidone 1500g

[0070] Polyethylene glycol 6000 800g

[0071] Anhydrous glucose 600g

[0072] Magnesium Stearate 100g

[0073] Concrete preparation steps are:

[0074] (1) Dry oxytetracycline hydrochloride, tartaric acid, sodium bicarbonate, polyethylene glycol 6000, and anhydrous glucose, pass through an 80-mesh sieve, and set aside;

[0075] (2) Weigh each component in step (1), and mix them uniformly to form a powder mixture in an equal increment method;

[0076] (3) Dissolve polyvinylpyrrolidone in 95% ethanol solution, mix well, and set aside;

[0077] (4) Spray polyvinylpyrrolidone ethano...

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Abstract

The invention belongs to the technical field of medicine preparation, and relates to an oxytetracycline hydrochloride effervescent tablet for dairy cattle and a preparation method thereof. The effervescent tablet comprises the following compositions in percentage by weight: 15-40 percent of oxytetracycline hydrochloride, 10-30 percent of tartaric acid, 15-45 percent of sodium bicarbonate, 1-15 percent of polyvinylpyrrolidone, 1-10 percent of polyethylene glycol 6000, 1-30 percent of anhydrous glucose, and 0.01-3 percent of magnesium stearate. The preparation method comprises the following steps: raw material preprocessing-mixing-preparation of soft material-granulation-drying-granular straightening-tabletting. The oxytetracycline hydrochloride effervescent tablet for dairy cattle has the advantages of being convenient to carry and use, good in effect, strong in stability and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to an oxytetracycline hydrochloride effervescent tablet for cows and a preparation method thereof. Background technique [0002] In recent years, with the development of the dairy farming industry, the number of vaginal and uterine diseases such as endometritis, vaginitis, pyometra, postpartum infection, and retained placenta caused by pathogenic microorganisms such as bacteria, fungi, mycoplasma, and viruses has gradually increased. It has caused huge economic losses to the dairy farming industry. Therefore, it is urgent to strengthen the prevention and treatment of dairy cow vaginal and uterine diseases to ensure the healthy and sustainable development of the dairy farming industry, thereby improving the economic benefits of the dairy farming industry. [0003] The chemical name of oxytetracycline hydrochloride is 6-methyl-4-(dimethylamino)-3,5,6,10,12,12α...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K31/65A61K47/34A61P31/04A61P31/10A61P31/12A61P15/00A61P15/02A61K47/10
Inventor 郭玉凡陈盟张宁周衡王佳伟
Owner ZHENGZHOU BARY ANIMAL PHARMA
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