Florfenicol solution and preparation method thereof

A technology of florfenicol solution, applied in the field of florfenicol solution and its preparation

Inactive Publication Date: 2011-06-29
上海恒丰强生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] currently used florfenicol solution is to use organic solvent as solvent completely, which increases the irritation to animals, also increases the production cost of enterprises, and also increases the The cost of medication for farmers, therefore, the clinical use of Florfenicol solution is greatly restricted in the prevention and treatment of animal diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Step (2): Then add 10 ml triacetin, stir for 2 minutes to dissolve,

[0024] Step (3): Add 10ml of Tween-80, stir for 5 minutes to fully dissolve,

[0025] Step (4): Add water to 100ml, stir until dissolved.

[0026] [Example 2]

[0027] A kind of florfenicol solution is made by following method

Embodiment 2

[0029] Step (2): Then add 15 ml triacetin, stir for 2 minutes to dissolve,

[0030] Step (3): Add 15ml of Tween-80, stir for 5 minutes to fully dissolve,

[0031] Step (4): Add water to 100ml, stir until dissolved.

[0032] [Example 3]

[0033] A kind of florfenicol solution is made by following method

Embodiment 3

[0035] Step (2): Then add 10 ml triacetin, stir for 2 minutes to dissolve,

[0036] Step (3): Add 20ml of Tween-80, stir for 5 minutes to fully dissolve,

[0037] Step (4): Add water to 100ml, stir until dissolved.

[0038] 【Example 4】

[0039] A kind of florfenicol solution is made by following method

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PUM

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Abstract

The invention relates to a florfenicol solution and preparation method thereof, wherein the florfenicol solution comprises the following components of: florfenicol, N, N-dimethylformamide (DMF), glycerol triacetate, tween-80 and water; the mass ratio of each component is florfenicol: DMF: glycerol triacetate: tween-80: water = (5-15): (40-60): (10-15): (1-20): 100. The preparation method of the solvent comprises the following steps of: taking 45ml of DMF, adding the DMF into the florfenicol, stirring to be dissolved; then adding glycerol triacetate, stirring to be dissolved, and then adding tween-80, stirring to be dissolved; finally adding water to 100 ml, and stirring until the solution is clear. The florfenicol solution prepared by the method can be dissolved in the water at any proportion; the florfenicol solution greatly improves the bioavailability of the products, and is featured with rapid effect, long effect and high efficiency; and the florfenicol solution can maintain long effective blood concentration in the live stock.

Description

[0001] technical field [0002] The invention relates to a florfenicol solution and a preparation method thereof. technical background [0003] Florfenicol is a chloramphenicol-like broad-spectrum veterinary antibacterial drug, and its antibacterial activity is higher than that of chloramphenicol and thiamphenicol, especially for some bacteria resistant to chloramphenicol and thiamphenicol. High antibacterial activity. The characteristics are as follows: (1) It has an extremely broad antibacterial spectrum, and has a strong killing effect on both Gram-positive bacteria and negative bacteria. Parasite etc. have strong antibacterial effect. (2) In vivo and in vitro tests show that its antibacterial activity is significantly better than the current antibacterial drugs, such as: chloramphenicol, thiamphenicol, oxytetracycline, tetracycline, ampicillin and currently widely used quinolones. (3) Quick-acting: 1 hour after intramuscular injection, the therapeutic concentration ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/165A61K47/34A61P31/04A61K47/26
Inventor 郗洪生龙谭廖洪高建辉郭春艳
Owner 上海恒丰强生物技术有限公司
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