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Gardenia total polyene composition, preparation method thereof and application thereof to medicaments

A kind of composition, the technology of gardenia, applied in the field of medicine, can solve the problems such as no literature mentioning pharmacological activity and use

Inactive Publication Date: 2011-06-15
广州艾格生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there are many literature reports on the anti-tumor, anti-atherosclerosis, anti-hypertensive and treatment of hemorrhagic shock, anti-oxidation, liver-protecting and choleretic effects of single compounds such as crocetin and crocetin; but these crocetin and saffron Sudo is derived from saffron, and there is no literature that mentions these specific conjugated polyene compositions or the total conjugated polyene parts in gardenia, as well as related pharmacological activities and uses.

Method used

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  • Gardenia total polyene composition, preparation method thereof and application thereof to medicaments
  • Gardenia total polyene composition, preparation method thereof and application thereof to medicaments
  • Gardenia total polyene composition, preparation method thereof and application thereof to medicaments

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Experimental program
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Effect test

Embodiment 1

[0057] Take 10kg of gardenia, crush it, extract it with petroleum ether (60-90°C) three times, 1 hour each time, extract the dregs with ethanol three times, combine the filtrates three times, recover the ethanol until it has no alcohol smell, and put it on the treated D101 macroporous resin Column, eluted with water first, eluted with 25% ethanol, collected the 35% ethanol eluate, concentrated the eluate to dryness, dissolved in ethanol and added silica gel to mix the sample, put it on the silica gel column, and used ethyl acetate:methanol:water=9 : 2: 1 elution, collected all the conjugated polyene compounds, and the content of gardenia conjugated polyene compounds was determined to be 98.7%. Among them, mainly crocetin and crocin, the content ratio is 50:50.

Embodiment 2

[0059] Take 10kg of gardenia, crush it, extract it with petroleum ether (60-90°C) three times, each time for 1 hour, extract the dregs with ethanol three times, combine the three filtrates, recover the ethanol until it has no alcohol smell, and put it on the processed AB-8 Hole resin column, first eluted with water and 20% ethanol, collected 40% ethanol eluate, concentrated eluate to dryness, dissolved in ethanol and added silica gel to mix the sample, put it on a silica gel column, and used ethyl acetate:methanol:water =10:2:1 elution, the total conjugated polyene compound sites were collected, and the content of gardenia conjugated polyene compound was determined to be 67%. Among them, crocetin, crocin and methyl crocetin are mainly contained, and the content ratio thereof is 30:68:2.

Embodiment 3

[0061] Take 10kg of gardenia, crush it, extract it with petroleum ether (60-90°C) three times, each time for 1 hour, extract the dregs with ethanol three times, combine the three filtrates, recover the ethanol until it has no alcohol smell, and put it on the treated D104 macroporous resin Column, eluted with water first, eluted with 20% ethanol, collected the 35% ethanol eluate, concentrated the eluate to dryness, dissolved in ethanol and added silica gel to mix the sample, put it on the silica gel column, and used ethyl acetate:methanol:water=11 : 2: 1 elution, and all the conjugated polyene compounds were collected, and the content of gardenia conjugated polyene compounds was determined to be 93.2%. The main ones are crocetin, crocetin and dimethyl crocetin, the content ratio of which is 34:65:1.

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Abstract

The invention relates to a gardenia total conjugate polyene composition, a preparation method thereof and application thereof to medicaments, and belongs to the field of the medicaments. According to tests, conjugate polyene compounds in gardenia have synergistic effect. Tumor resistance, hypertension resistance and hyperlipidemia resistance of the gardenia total conjugate polyene composition are higher than those of a control group and a single polyene compound such as crocetin and crocin. The preparation method of the gardenia total conjugate polyene composition is provided.

Description

technical field [0001] The invention relates to a total conjugated polyene composition of Gardenia jasminoides, a preparation method thereof and an application in medicine, belonging to the field of medicine. Background technique [0002] Gardenia is the dry ripe fruit of plants in the genus Gardenia of the Rubiaceae plant. Produced in the provinces south of the Yangtze River. Gardenia is a traditional Chinese medicine, which belongs to the first batch of medicinal and edible resources promulgated by the Ministry of Health. contusion, high blood pressure, diabetes and other diseases. In addition to its application in traditional Chinese medicine, gardenia is mainly used as a raw material for extracting natural pigments, and is used to prepare gardenia blue, gardenia red, and gardenia yellow pigments. [0003] Studies have found that there are many chemical components in gardenia, mainly: iridoid glycosides and organic acids. Among them, the iridoid glycoside compounds in...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K31/194A61K31/22A61K9/20A61K9/48A61K9/16A61K9/00A61K9/08A61K9/14A61P35/00A61P9/00A61P9/12A61P3/10A23L1/29A23L33/00
Inventor 张雷红
Owner 广州艾格生物科技有限公司
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