Ibuprofen nanoemulsion and preparation method thereof

A technology of nanoemulsion and triacetin, used in emulsion delivery, non-central analgesics, antipyretics, etc.

Inactive Publication Date: 2011-06-15
上海恒丰强生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Ibuprofen is difficult to dissolve in water. Therefore, in the prevention and treatment of animal diseases, ibuprofen is used in the form of powder mixture. For large-scale For poultry farming, it is very inconvenient to use
Clinical use is very limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Step (2): Then add the vomiting temperature -80 15 ml, stir for 2 minutes to dissolve it,

[0023] Step (3): Add water to 100 ml and stir until dissolved.

[0024] 【Example 2】

[0025] A ibuprofen nanomaline milk is made by the following method

Embodiment 2

[0027] Step (2): Then add the vomiting temperature-80 ml, stir for 2 minutes to dissolve it,

[0028] Step (3): Add water to 100 ml and stir until dissolved.

[0029] 【Example 3】

[0030] A ibuprofen nanomaline milk is made by the following method

Embodiment 3

[0032] Step (2): Then add the vomiting temperature-80 ml, stir for 2 minutes to dissolve it,

[0033] Step (3): Add water to 100 ml and stir until dissolved.

[0034] 【Example 4】

[0035] A ibuprofen nanomaline milk is made by the following method

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PUM

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Abstract

The invention relates to ibuprofen nanoemulsion and a preparation method thereof. The ibuprofen nanoemulsion comprises ibuprofen, glycerol triacetate, Tween-80 and water in a mass ratio of (1-5):(5-15):(10-20):(20-100). The preparation method of the solvent comprises: adding ibuprofen into 10 milliliters of glycerol triacetate, and stirring to dissolve ibuprofen; adding Tween-80, and stirring for 2 minutes to dissolve the Tween-80; and adding water till the total volume is 100 milliliters, and stirring till the solution is clear. The ibuprofen nanoemulsion prepared by the method can dissolve in water according to any ratio, so the biological utilization rate of the product is improved greatly; and the ibuprofen nanoemulsion has the characteristic of instant, long and high effectiveness, and can keep an effective blood medicine concentration for a long time in the bodies of livestock.

Description

Technical field [0001] The present invention involves a ibuprofen nanomal milk and its preparation methods. technical background [0002] Ibuprofen is a non -steroid anti -inflammatory drug, which has excellent anti -inflammatory, analgesic, and heat -relieving effects. [0003] The mechanism of analgesia and anti -inflammatory effects of this product has not yet been fully clarified, which may act on the part of the inflammatory tissue. By inhibiting the synthesis of prostaglandin or other transplants, due to the inhibition of leukocyte activity and enzyme enzyme release, the tissue is locally local.Pain impulse decreases, and the sensitivity of the pain receptor is reduced.Treatment of gout is through anti -inflammatory, analgesic, and can not correct hyperuricemia.The mechanism of the treatment of dysmenorrhea may be that prostaglandin synthesis is inhibited and the intrauterine pressure decreases and contractions.Oral absorption is easy to absorb, and the absorption is slowed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/192A61K47/34A61P29/00A61K47/14A61K47/26
Inventor 龙谭廖洪李敏郭春艳
Owner 上海恒丰强生物技术有限公司
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