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Traditional Chinese medicine for preventing and treating Alzheimer disease and preparation method thereof

A technology of Alzheimer's disease and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine for preventing and treating Alzheimer's disease and its preparation, which can solve the problems that the disease process cannot be changed, and achieve the effect of low cost and simple production process

Active Publication Date: 2012-08-22
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most commonly used cholinesterase inhibitors can only relieve symptoms, not change the course of the disease

Method used

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  • Traditional Chinese medicine for preventing and treating Alzheimer disease and preparation method thereof
  • Traditional Chinese medicine for preventing and treating Alzheimer disease and preparation method thereof
  • Traditional Chinese medicine for preventing and treating Alzheimer disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A traditional Chinese medicine compound component for preventing and treating Alzheimer's disease, which is composed of the following raw materials in parts by mass: 16 parts of Radix Polygoni Multiflori, 12 parts of Ginseng, 14 parts of Shichangpu, 10 parts of Rhizoma Chuanxiong and 9 parts of Coptidis Rhizome.

[0038] The preparation method of this traditional Chinese medicine can be prepared into a traditional Chinese medicine preparation, and its preparation method is as follows: figure 2 shown, including the following process:

[0039] (1) Take 14 parts of Acorus calamus, add 8 times the mass of water to soak for 2 hours, use steam distillation to reflux extraction, the time is 6 hours, collect the upper layer oil, add anhydrous sodium chloride saturated solution to make the stratification more obvious, and separate the water layer, and then dried with anhydrous sodium sulfate, and finally a light yellow transparent liquid is the aromatic volatile oil of Acorus c...

Embodiment 2

[0045] A traditional Chinese medicine for preventing and treating Alzheimer's disease, which is composed of the following raw materials in parts by mass: 13 parts of Radix Polygoni Multiflori, 10 parts of Ginseng, 12 parts of Shichangpu, 6 parts of Coptis Rhizoma and 9 parts of Chuanxiong Rhizoma.

[0046] The preparation method of this traditional Chinese medicine can be prepared as a traditional Chinese medicine preparation, and the aromatic volatile components of Acorus calamus obtained in step (1) are made into β-CD inclusions, mixed in, and dried. All the other are with embodiment 1. This traditional Chinese medicine can be made into dosage forms of granules, capsules, soft capsules, granules, dripping pills and decoctions.

Embodiment 3

[0048] A traditional Chinese medicine combination for preventing and treating Alzheimer's disease, which is composed of the following raw materials in parts by mass: 12 parts of Radix Polygoni Multiflori, 9 parts of Ginseng, 10 parts of Shichangpu, 5 parts of Coptis Rhizoma and 6 parts of Chuanxiong Rhizoma.

[0049] The preparation method of this traditional Chinese medicine can be to prepare the active component extract of traditional Chinese medicine, and its preparation method refers to figure 1 The process shown includes the following:

[0050] (1) Grind 12 parts of Radix Polygoni Multiflori, 9 parts of Ginseng, 10 parts of Shichangpu, 5 parts of Coptis Rhizoma and 6 parts of Chuanxiong Rhizoma Rhizoma Chuanxiong, and mix them evenly. 3 times, each reflux time is 90min, and the filtrates are combined;

[0051] (2) reflux the medicinal dregs in the step (1) twice with 8 times the volume of water, each time for 120 min, add 4 times the volume of absolute ethanol after merg...

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Abstract

The invention discloses a traditional Chinese medicine for preventing and treating Alzheimer disease and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 12-16 parts of prepared fleece flower root, 8-12 parts of ginseng, 9-13 parts of rhizoma acori graminei, 5-9 parts of coptis and 6-10 parts of chuanxiong rhizome. Thetraditional Chinese medicine can be prepared into granules, capsules, soft capsules, dissolved medicines, dripping pills and soft extracts, has the advantages of simple manufacturing process and low cost, is completely prepared from natural plants, does not contain hormones, has no addition of pigments and other chemical synthetics, and does not have toxic side effects on human bodies after beingcontinuously used. The traditional Chinese medicine contains various effective components such as flavones, saponins, phenolic acids, alkaloids, polysaccharides and the like capable of being easily absorbed by human bodies, can be effectively used for nourishing the kidney and invigorating the brain, replenishing qi and dissolving turbidity and promoting blood circulation and eliminating toxicity, and is suitable for treating deficiency of the kidney, mild cognitive impairment caused by obstruction of the orifices by blood stasis, Alzheimer disease and the like.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for preventing and treating Alzheimer's disease and a preparation method thereof. Background technique [0002] Alzheimer's disease (Alzheimer disease, AD) is dementia caused by chronic progressive central nervous system degenerative lesions, and is the most common senile dementia. It is characterized by neuropsychiatric symptoms such as cognitive dysfunction and personality abnormalities. AD is the most common type of degenerative diseases of the nervous system. The incidence of AD increases with age. The prevalence rate is 5%-10% for those over 65 years old and 20%-50% for those over 85 years old. [0003] With the aging of the world's population, the incidence of AD is on the rise. At present, the disease has become the fourth leading cause of life-threatening diseases in the elderly (after heart disease, tumor and stroke), and it has become the most serious problem faced by geriatrics. one o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/888A61P25/28
Inventor 李浩刘剑刚刘龙涛刘美霞魏芸官杰
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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