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Ephedra-houttuynia cordata oral liquid and preparation method thereof

A technology of grass oral liquid and Houttuynia cordata, which is applied in the field of poultry pharmaceutical preparations and its preparation, can solve the problems of slow onset of action, low drug absorption and utilization, and difficult control of dosage, so as to improve curative effect, reduce production cost, simplify The effect of the extraction process

Active Publication Date: 2011-06-01
河北征宇制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the powder also has the problems of slow onset of action and low drug absorption and availability
Furthermore, the pharmaceutical preparation is usually mixed with the feed of the powder and the poultry and eaten together, so the dosage of the medicine depends entirely on the feed intake of the sick chicken, but the appetite of the sick chicken is dependent on the degree of illness. Inversely proportional, that is to say, the more serious the sickness of the sick chicken, the worse the appetite, and the worse the appetite, the less the amount of medicine taken, which shows that the dosage of the medicine preparation is not easy to control
In addition, eggs, broilers and poultry are usually fed mainly pellet feed, so it is difficult to mix the powder and pellet feed evenly, which also affects the quantitative drug administration.

Method used

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  • Ephedra-houttuynia cordata oral liquid and preparation method thereof
  • Ephedra-houttuynia cordata oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] a. Take by weighing 30g ephedra, 80g scutellaria baicalensis, 50g houttuynia cordata, 60g Andrographis paniculata, and 20g Radix Radix Radix according to the following weight ratios, and grind them into coarse powder for later use;

[0075] b. Distill the ephedra and Houttuynia cordata with steam, collect the volatile oil, and leave the remaining liquid and residue for later use;

[0076] c. Mix Scutellaria baicalensis with the residual liquid and residues of step b, decoct twice, the first time for 1 hour, filter the second time, combine the two filtrates, concentrate to 1 / 4 of the original liquid, add ethanol to make alcohol-containing When the amount reaches 70% (v / v), let stand, filter, and save the filtrate; add 95% ethanol to the precipitate, stir, let stand, filter, combine the two filtrates, and recover ethanol until there is no ethanol smell;

[0077] d, andrographis paniculata coarse powder is soaked with 85% (v / v) ethanol, 2 times, 48 ​​hours for the first ti...

Embodiment 2

[0081] a. Take 50g ephedra, 60g scutellaria baicalensis, 80g houttuynia cordata, 80g Andrographis paniculata, and 30g isatidis root according to the following weight ratios, and grind them into coarse powder for later use:

[0082] b. Distill the ephedra and Houttuynia cordata with steam, collect the volatile oil, and leave the remaining liquid and residue for later use;

[0083] c. Mix Scutellaria baicalensis with the residual liquid and residues of step b, decoct twice for 1 hour each time, filter, combine the two filtrates, concentrate to 1 / 3 of the original liquid, add ethanol to make the alcohol content reach 60% (v / v), stand still, filter, save the filtrate; add 80% (v / v) ethanol to the precipitation, stand still, filter, combine the two filtrates, reclaim ethanol until there is no ethanol smell;

[0084] d, andrographis paniculata coarse powder is soaked with the ethanol of 75% (v / v), 2 times, each 36 hours, soaking solution reclaims ethanol to no ethanol smell;

[008...

Embodiment 3

[0088] a. Weigh 68g ephedra, 80g scutellaria baicalensis, 160 parts g of houttuynia cordata, 80g of Andrographis paniculata, 100g of Radix isatidis according to the following weight ratios, cut into pieces for later use;

[0089] b. Distill the ephedra and Houttuynia cordata with steam, collect the volatile oil, and leave the remaining liquid and residue for later use;

[0090] c. Mix Scutellaria baicalensis with the residual liquid and residue of step b, decoct twice, filter, combine the two filtrates, concentrate, add ethanol to make the alcohol content reach 40 (v / v), let stand, filter, and store Filtrate; add 75% (v / v) ethanol to the precipitate, let it stand, filter, combine the two filtrates, and reclaim ethanol until there is no ethanol smell;

[0091] d, Andrographis paniculata are soaked with 70% (v / v) ethanol, 2 times, each 96 hours, and the soaking solution reclaims ethanol until there is no ethanol smell;

[0092] e. Add 70% (v / v) ethanol to 70% (v / v) ethanol to r...

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Abstract

The invention discloses an ephedra-houttuynia cordata oral liquid and a preparation method thereof. The preparation method comprises the following steps of: weighing ephedra, scutellaria baicalensis, houttuynia cordata, herba andrographitis and isatis root; distilling the ephedra and the houttuynia cordata through steam, and collecting the volatile oil; mixing the residual liquid and residual liquid of the scutellaria baicalensis and the ephedra and houttuynia cordata, decocting the mixture, concentrating the filtrate, precipitating filtrate by alcohol, adding alcohol again after precipitation, filtrating and recycling; and reflux-extracting the herba andrographitis and the isatis root respectively by alcohol, mixing all extracts with the volatile oil, adding water properly, controlling the relative density within 1.02 to 1.15, and sterilizing to obtain the oral liquid. The oral liquid solves the problem of inconvenient quantitative dosing of pulvis; more importantly, in selection of drug components and the method, different medicinal materials are purified by different extracting methods, thus the curative effect of the oral liquid is greatly improved.

Description

technical field [0001] The invention relates to a poultry pharmaceutical preparation and a preparation method thereof, in particular to a pharmaceutical preparation especially suitable for treating avian mycoplasma disease and a preparation method thereof. technical background [0002] Avian mycoplasma disease, also known as avian mycoplasma disease, is a general term for a class of diseases caused by mycoplasma. Mainly include chicken chronic respiratory disease, infectious synovitis and turkey mycoplasma disease. The disease is widely distributed in the whole world, and it is a frequently-occurring disease in chicken farms. It can cause a decline in the carcass grade of chickens, a reduction in feed remuneration, slow growth, and reduced egg production. Avian mycoplasma disease can be transmitted horizontally or vertically, and it is often mixed with diseases that cause respiratory symptoms such as Escherichia coli, infectious rhinitis, Newcastle disease and infectious br...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/00A61P31/00
Inventor 刘学彬张晓云冯英珍牛延忠陈利英
Owner 河北征宇制药有限公司
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