Core-shell microcapsule and preparation method thereof

Abstract

The invention discloses a core-shell microcapsule and a preparation method thereof. The core-shell microcapsule comprises a core layer and a shell layer, wherein the core layer and shell layer are composed of different biomacromolecules with the weight-average molecular weight of 0.05-0.5 million; the mass percentage of the core layer is 20-95%, and the mass percentage of the shell layer is 5-80%; and the core layer and shell layer further contain growth factors and / or medicaments, thereby achieving different functions of the microcapsule. Through adopting a coaxial system, core layer and shell layer biopolymer material solution is formed, so as to obtain the core-shell microcapsule. The preparation method has the characteristics that the process is simple, the operation is convenient, and the cost is low; the obtained microcapsule has the advantages of good biocompatibility, biodegradation and bioabsorbability, can carry the active growth factors and the medicaments, achieves separate controlled release, and has wide application prospect in the fields such as tissue engineering scaffold materials, stem cell study, medicine controlled release and the like.

Description

technical field [0001] The invention relates to a microcapsule with a specific structure and a preparation method thereof, more specifically, a core-shell structure microcapsule and a preparation method thereof. Background technique [0002] In drug delivery, tissue engineering, and even stem cell research, the use of appropriate biomolecular delivery vehicles is crucial, especially in the study of stem cell tissue regeneration, because the differentiation of stem cells is controlled by a specific relationship in time and space. Stem cell behavior is determined by growth factors or hormones, so the nature of the growth factor delivery system can control stem cell behavior. At present, the microencapsulation of drugs, proteins or other biodegradable polymers is a widely recognized method for effectively preparing microcapsules for carrying and storing targeted biomolecules, such as biodegradable microcapsules prepared by double emulsifier evaporation method. Polymer microsph...

AI Technical Summary

Problems solved by technology

In this process, the high-voltage electric field will make the polymer liquid charge in the capillary, which will cause the cone ejection phenomenon to occur at the tip of the nozzle. In this case, the high-viscosity polymer solution will be stretched and bent into microns or Nano-scale fibers, while those of a dilute polymer solution will be broken into small droplets, and with the increase of the electric field strength, it will drop from drop to cone drop in the form of a jet. This method is suitable for producing liquids with uniform size. The compatibility of small droplets, but it is difficult to precisely control the size and shape of microcapsules by electrospraying technology