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Slow-release regulating agent for preventing rumen acidosis and preparation method thereof

A rumen acidosis and regulating agent technology, applied in the direction of anti-toxic agents, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to enhance the therapeutic effect, promote digestion and absorption, and reduce direct damage.

Active Publication Date: 2012-04-25
SICHUAN AGRI UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching, in the patent office database of the State Intellectual Property Office, there is currently no public report on the slow-release regulator for the prevention of ruminal acidosis

Method used

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  • Slow-release regulating agent for preventing rumen acidosis and preparation method thereof
  • Slow-release regulating agent for preventing rumen acidosis and preparation method thereof
  • Slow-release regulating agent for preventing rumen acidosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take 3kg of sodium bicarbonate, 1.5kg of magnesium oxide, 0.1kg of nicotinic acid, cobalt sulfate, and zinc sulfate powder and pass through a 100-mesh sieve, add 3kg of starch, 0.1kg of hydroxypropyl methylcellulose (HPMC), stir in a mixer for 10 minutes and mix well .

[0037] Add 1.5 liters of absolute ethanol (adding PVP to make 6% concentration). (Anhydrous ethanol is used as a binder, it only needs to be able to bind the prescription powder into granules), stir for 30 minutes and put it in a granulator to granulate; and put it in a drying equipment for drying at 36-40°C, and granulate with a 16-mesh sieve , weighed, add magnesium stearate 0.077kg and mix. Calculate the weight of the tablet and press the tablet.

Embodiment 2

[0039] Take 5 kg of sodium bicarbonate, 1.7 kg of magnesium oxide, 0.3 kg of nicotinic acid, cobalt sulfate, and zinc sulfate powder through a 100-mesh sieve, add 15 kg of starch, and 0.3 kg of hydroxypropyl methylcellulose (HPMC) and stir in a mixer for 10 minutes to mix.

[0040] Add 4.3 liters of absolute ethanol (add PVP to make 6% concentration), stir for 30 minutes, place in a granulator to granulate; and place in a drying equipment for drying at 36-40°C, granulate with a 16-mesh sieve, weigh, and add stearin Magnesium acid 0.22kg, mix well. Calculate the weight of the tablet and press the tablet.

Embodiment 3

[0042] Take 4kg of sodium bicarbonate, 1.6kg of magnesium oxide, 0.2kg of nicotinic acid, cobalt sulfate, and zinc sulfate powder through a 100-mesh sieve, add 3kg of starch, and 0.2kg of hydroxypropyl methylcellulose (HPMC) and stir in a mixer for 10 minutes to mix. Add 1.75 liters of absolute ethanol (adding PVP to make 6% concentration), stir for 30 minutes, place in a granulator to granulate; dry at 36-40°C, granulate with a 16-mesh sieve, weigh, add magnesium stearate 0.09 kg, mix well. Calculate the weight of the tablet and press the tablet.

[0043] Two examples of application examples and test reports are provided below:

[0044] Rumen slow-release regulator suitable for ruminal acidosis of growing and fattening cattle: During the rapid growth stage of growing and fattening cattle, a large amount of concentrate is fed to cause rumen acidosis. Combine nutritional requirements and dry matter intake (average 2.5% of body weight) of finishing cattle. Feed 100-200 rumen su...

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Abstract

The invention discloses a slow-release regulating agent for preventing rumen acidosis and a preparation method thereof, which relate to the field of scientific nutrition of animals. The slow-release regulating agent comprises the following raw material components by gram: 0.3 to 0.5 gram of sodium bicarbonate, 0.15 to 0.17 gram of magnesium oxide, 0.01 to 0.03 gram of nicotinic acid, 0.01 to 0.03gram of cobaltous sulfate, 0.01 to 0.03 gram of zinc sulfate, 0.01 to 0.03 gram of hydroxypropyl methyl cellulose and 0.3 to 1.5 gram of starch. The preparation method comprises the following preparation steps of: 1. sieving the sodium bicarbonate, the magnesium oxide, the nicotinic acid, the cobaltous sulfate and the zinc sulfate; 2. uniformly mixing the sieved components and an appropriate amount of starch; 3. adding an appropriate amount of absolute ethyl alcohol and stirring for pelletizing; 4. drying and weighing; 5. adding the sodium bicarbonate and mixing uniformly; and 6. calculating tablet weight and tableting. With the invention, the conventional method in which excessive volatile fatty acid produced in a rumen is neutralized by directly filling sodium bicarbonate or adding magnesium oxide is changed. Rumen acidosis is prevented, the treatment effect on rumen acidosis is enhanced, and direct damages to the rumen membranes of ruminants and microbial floras in rumens are reduced.

Description

technical field [0001] The invention relates to the field of animal science and nutrition, in particular to a slow-release regulating agent for preventing ruminal acidosis required for the regulation and control of rumen fermentation of ruminants and a preparation method thereof. Background technique [0002] Sustained Release Dosage Forms (SRDF), also known as Sustained Release Dosage Forms (SRDF), is a dosage form that maintains the drug concentration within the effective concentration range for a long time within a predetermined period of time. Because its drug release rate conforms to the first-order kinetics, the drug can exert its drug effect in the body for a long time, thereby prolonging the action time of the effective concentration of the drug and reducing the peak and valley phenomenon of the drug concentration in the body, so that the number of adverse reactions can be reduced And degree, improve security. [0003] Sustained-release technology has been widely us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/30A61K9/22A61K47/38A61P1/00A61P39/02A61K31/455A61K33/00A61K33/08A61K33/24
Inventor 董利锋
Owner SICHUAN AGRI UNIV
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