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Application of testosterone propionate as medicine for constructing animal model with dysspermia

An animal model, the technology of testosterone propionate, is applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, which can solve the problem of no animal model of abnormal semen being constructed.

Active Publication Date: 2011-05-25
吴效科
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing studies have shown that although testosterone enanthate and testosterone cyclobutanate in testosterone can inhibit spermatogenesis, this process is reversible, and the semen routine returns to normal after stopping the drug, so it cannot be used to construct animals with abnormal semen model tools
[0006] So far, there is no report on the establishment of animal models of abnormal semen

Method used

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  • Application of testosterone propionate as medicine for constructing animal model with dysspermia
  • Application of testosterone propionate as medicine for constructing animal model with dysspermia
  • Application of testosterone propionate as medicine for constructing animal model with dysspermia

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experiment example

[0020] 1. Experimental materials

[0021] 1.1 Experimental animals

[0022] Wistar rats, 10 females, weighing (250±20) g, and 5 males, weighing (300±20) g, were purchased from the Animal Experiment Center of Heilongjiang University of Traditional Chinese Medicine.

[0023] 1.2 Drugs and reagents

[0024] Testosterone propionate (purchased from Tianjin Jinyao Amino Acid Co., Ltd.); Tween 80 (Tianjin Bodi Chemical Co., Ltd.); goat anti-mouse P450c17 antibody (SAN2TA CRUZ, USA); horseradish enzyme-labeled rabbit anti-goat IgG (Beijing Bio Orson Biotechnology Co., Ltd.).

[0025] 1.3 Main instruments

[0026] Tissue slicer, Shanghai Leica Instrument Equipment Co., Ltd.; ordinary optical microscope (CK2Z), Japan OLYM2PUS company; electronic precision balance (L Ibror AEL2200), Japan Shimadzu product.

[0027] 2. Experimental method

[0028] 2.1 Model establishment

[0029] The male and female rats were caged at a ratio of 2:1, and the vaginal smear was used to search for sper...

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Abstract

The invention discloses the application of testosterone propionate as a medicine for constructing an animal model with dysspermia. An animal experiment shows that: the spermatogenesis of an experimental animal can be effectively suppressed and the quality and activity of sperm are reduced after the in vitro injection of the testosterone propionate, and semen routines (the count, quality and activity of the sperm) of the experimental animal cannot be restored after the in vitro injection of the testosterone propionate is stopped, so the process is irreversible. The experimental result shows that: the testosterone propionate serving as the medicine can be used for constructing the animal model with the dysspermia.

Description

technical field [0001] The invention relates to a new use of testosterone propionate, in particular to the use of testosterone propionate as a tool drug for constructing abnormal semen animal models, and belongs to the field of medical uses of testosterone propionate. Background technique [0002] Testosterone, also known as testosterone, testosterone, or testosterone, is a steroid hormone secreted by the testes in men or the ovaries in women, and in small amounts by the adrenal glands. It is the main male sex hormone and anabolic hormone. Whether it is a man or a woman, it has important health effects, including enhancing libido, strength, immune function, and fighting osteoporosis. Testosterone mainly includes testosterone cypionate, testosterone enanthate, testosterone acetylene, testosterone caprate acetate, methyltestosterone, testosterone phenylacetate, testosterone propionate and testosterone cyclobutyl ester. [0003] There are many reasons for male infertility, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5685A61P15/08
Inventor 吴效科马红丽丛晶李楠
Owner 吴效科
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