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Application of berberine to preparing drug for preventing and treating familial adenomatous polyp

A technology of berberine and family, applied in the field of application of berberine in the preparation of drugs for the prevention and treatment of familial adenomatous polyps, can solve problems such as unclear molecular mechanism, and achieve good prevention and treatment effect

Inactive Publication Date: 2011-05-18
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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Problems solved by technology

In recent years, scholars at home and abroad have also found that berberine has an anti-tumor effect, but the specific molecular mechanism is still unclear.

Method used

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  • Application of berberine to preparing drug for preventing and treating familial adenomatous polyp
  • Application of berberine to preparing drug for preventing and treating familial adenomatous polyp
  • Application of berberine to preparing drug for preventing and treating familial adenomatous polyp

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Embodiment Construction

[0012] Berberine inhibits the proliferation of FAP cell lines: In recent years, the dysregulation of EGFR signaling pathway is closely related to the occurrence and carcinogenesis of FAP polyps, and it is an important target for tumor prevention and treatment. Colonic polyps and tumor epithelium highly express EGFR, which stimulates its autophosphorylation through dimerization after being activated by ligands such as EGF, leading to cascade amplification and activation of downstream signaling pathways. The classic EGFR pathways mainly include: ① Mitogen-activated protein kinase pathway (Ras / Raf / MEK / ERK / MAPK pathway): by activating extracellular signal-regulated protein kinase 1 (ERK1), ERK2 and JNK / p38-MAPK, etc. , phosphorylate cytoplasmic proteins, and also enter the nucleus to phosphorylate transcription factors, activate nuclear AP-1, and mainly mediate cell proliferation and differentiation; ② Phosphatidylinositol 3-kinase (PI3K) pathway: the product of PI3K, PIP3, regulat...

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Abstract

The invention relates to novel application of berberine, in particular to application of the berberine to preparing a drug for preventing and treating familial adenomatous polyp (FAP). The FAP is an autosomal dominant hereditary disease which is characterized by multiple adenomatous polyps in the digestive tract, mainly comprises CFAP (Classical Familial Adenomatous Polyp) and AFAP (Attenuated Familial Adenomatous Polyp) and is not rare in clinic; and early intervention is significant. In the invention, the applied berberine can bring inhibitory action to the cell growth of colon cancer cells and FAP cell line (IMCE), wherein the mechanism includes inhibiting cell proliferation, promoting apoptosis, down regulating expression of COX-2 and AP-1, inhibiting synthesis of PGE2 (Prostaglandin E2) and activation of EGFR (Epidermal Growth Factor Receptor) and Akt and brings out well effect when applied to FAP patients in a long term. The invention provides a novel safe, effective, and economic method for preventing and treating the FAP.

Description

【Technical field】 [0001] The invention relates to a new application of berberine, in particular to the application of berberine in the preparation of drugs for preventing and treating familial adenomatous polyps. 【Background technique】 [0002] Familial adenomatous polyposis (FAP) is an autosomal dominant genetic disease characterized by multiple adenomatous polyps in the digestive tract, and its pathogenesis is mainly related to Apc mutation. Due to the special genetic background of FAP, it has become one of the hotspots in the field of colorectal disease research. At present, it is considered that FAP mainly includes classical FAP (classical FAP, CFAP) and attenuated FAP (attenuated FAP, AFAP). CFAP is commonly known as FAP. If the number of polyps exceeds 100, it often has an obvious family history and the age of canceration is relatively young; if the number of AFAP polyps is less than 100, it is often combined with upper gastrointestinal polyps, and its canceration is ...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P1/00
Inventor 王邦茂方维丽鄢芳李姝曹海龙王涛姜葵张庆瑜杨玉龙
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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