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Preparation method of super-hydrophobic blood vessel stent for repairing angiorrhexis

A vascular stent, vascular rupture technology, applied in stents, drug devices, other medical devices, etc., can solve the psychological and physiological shock of patients and other problems, and achieve the effect of simple external stimulation method, good response characteristics, and small trauma.

Inactive Publication Date: 2012-07-18
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the blood vessel ruptures, a surgical operation is required, which is a huge blow to the patient's psychology and physiology, and the expensive medical expenses are also unaffordable for many patients

Method used

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  • Preparation method of super-hydrophobic blood vessel stent for repairing angiorrhexis

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Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0013] Specific Embodiment 1: The preparation method of the superhydrophobic vascular stent used for vascular rupture repair in this embodiment is realized according to the following steps: 1. The vascular network stent with a pore diameter of <40 mesh is degreased with an organic solvent, then dried at room temperature, and then After alkali washing and water washing, dry; 2. Put the tube mesh stent treated in step 1 into the perfluoroalkylsiloxane solution for 10-60s, take it out and dry it, repeat the operation of perfluoroalkylsiloxane Soak and dry in oxane solution for 2 to 8 times, and then dry at 110°C for 3 to 12 hours to obtain a superhydrophobic tube mesh stent; 3. Seal both ends of the superhydrophobic tube mesh stent, and then Immerse in the drug coating solution for 1 to 60 minutes, take it out and dry it, repeat the process of immersing in the drug coating solution and drying until the thickness of the drug coating on the surface of the stent is 1 to 100 μm, and t...

specific Embodiment approach 2

[0016] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the tube mesh vascular stent in step 1 is made of stainless steel fiber mesh, copper fiber mesh, iron fiber mesh, titanium fiber mesh or aluminum fiber mesh. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0017] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the organic solvent in step 1 is ethanol, acetone, ethyl acetate, toluene or xylene. Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

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Abstract

The invention discloses a preparation method of a super-hydrophobic blood vessel stent for repairing angiorrhexis, relating to a preparation method of a blood vessel stent. The method comprises the following steps of: degreasing a pipe-net-shaped blood vessel stent and drying after alkali washing and water washing; placing into a perfluoroalkyl siloxane solution to soak to obtain a super-hydrophobic pipe-net-shaped blood vessel stent; soaking into a drug eluting solution, and drying in vacuum to obtain the super-hydrophobic blood vessel stent. The invention realizes minimal invasion for simultaneously repairing angiorrhexis and treating diseases such as angiostenosis and the like for the first time. The surface of the super-hydrophobic blood vessel stent for repairing angiorrhexis, prepared with the method provided by the invention, is coated with hemostatics, blood cannot exude through the vessel wall at the treatment stage of an angiorrhexis part; after the treatment on the angiorrhexis part is finished, the stent allows blood to freely pass under the excitation of external factors to supply blood to vessels around the stent, not only can realize minimally invasive treatment on angiorrhexis, without influencing blood supply to the surrounding vessels, but also can finish treatment on angiostenosis diseases such as the coronary atherosclerotic heart disease and the like.

Description

technical field [0001] The invention relates to a preparation method of a vascular stent. Background technique [0002] Coronary atherosclerotic heart disease is one of the important causes of cardiovascular death, and vascular stent implantation has become a standard angioplasty method. Percutaneous transluminal angioplasty is to use a puncture needle, a guide wire and a guide sheath to insert a balloon catheter covered with a tightened stent into a human blood vessel, and deliver it to the stenosis of the blood vessel. With the expansion of the balloon, the stent is also stretched After the balloon is retracted and retracted, the plastically deformed metal stent remains in place and is embedded in the blood vessel to expand the blood vessel. [0003] Although percutaneous transluminal angioplasty is a relatively mature technique, vessel rupture due to operational errors and other reasons cannot be avoided. In particular, blood vessel rupture caused by mishandling of a pu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/90A61M31/00
Inventor 姜再兴黄玉东刘丽
Owner HARBIN INST OF TECH
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