Antiallergic medicament and application thereof

A technology of anti-allergic and antiviral drugs, applied in the field of adrenocorticotropic hormone drugs, can solve the problems of ineffective intraperitoneal injection

Inactive Publication Date: 2011-05-11
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The experimental results show that glycyrrhizic acid can indeed induce its own metabolism, but this effect is related to the administration route of glycyrrhizic acid. Glycyrrhizic acid can produce auto-induction effect, but intraperitoneal injection is invalid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Mix N[(3-p-methylphenyl-isoxazol-5-yl)methyl]-glycyrrhetinamide 25g, add lactose 43g, microcrystalline cellulose 16g, add appropriate amount of 10% hydroxypropylmethyl The cellulose solution is granulated, dried, and then added with 5.3 g of sodium carboxymethyl starch and 1.5 g of magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 2

[0025] N[(3-p-methylphenyl-isoxazol-5-yl) methyl]-glycyrrhetinamide 25g, add in the polyethylene glycol 4000 of 100g melting, in the polyethylene glycol 4000 of melting, stir All dissolved and mixed evenly, kept at a constant temperature of 60°C, dripped into liquid paraffin (5-10°C), condensed into drop pills, sucked up the liquid paraffin, selected granules, and obtained.

Embodiment 3

[0027] N[(3-p-methylphenyl-isoxazol-5-yl)methyl]-glycyrrhetinamide 100mg, microcrystalline cellulose 55mg, starch 45mg, hydroxymethylcellulose 4mg, carboxymethyl starch sodium salt 5mg , magnesium stearate 1mg, talcum powder 1mg, take an appropriate amount of each ingredient, sieve the active ingredient, starch and cellulose, and mix them well, mix the carboxymethylcellulose solution with the above powder, sieve, and get wet granules Dry at 50-60°C, pre-screen carboxymethyl starch sodium salt, magnesium stearate and talc, then add to the above granules and compress into tablets.

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PUM

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Abstract

The invention relates to a medicinal compound which prevents and treats diseases such as inflammation, allergy, infection and the like and a preparation method and application thereof. The invention also discloses a compound which comprises an active ingredient I serving as adrenomimetic cortical hormone or pharmaceutically acceptable salt of the compound and a medicinal composition consisting of one or more of pharmaceutically acceptable carriers, excipients or diluents.

Description

technical field [0001] The invention belongs to the field of adrenocortical hormone drugs, and relates to anti-inflammatory, anti-allergic, liver-protecting and anti-viral anti-allergic drugs and their application Background technique [0002] Modern studies have confirmed that glycyrrhizic acid (glyCyrrhizic acid, GA) is one of the most important active ingredients in licorice, which has anti-inflammatory, anti-viral, liver-protecting, detoxifying, and immune-enhancing effects. Since glycyrrhizic acid has the pharmacological effects of corticosteroids without serious adverse reactions, it is widely used in the treatment of various acute and chronic hepatitis in clinic. Bronchitis and AIDS, also has the functions of anti-cancer and anti-cancer, interferon inducer and cellular immune regulator. With the deepening of research, other functions of glycyrrhizic acid are also being gradually developed. Anti-inflammation is the most important pharmacological effect of glycyrrhizi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P29/00A61P37/08A61P1/16A61P31/12
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
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