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Dentin surface bionic hydroxyapatite coating preparation method

A biomimetic hydroxyapatite and dentin technology, used in dental preparations, dentistry, dentures, etc., can solve the problems of low mineralization, large differences, and low enamel organic components, and achieve orderly formation and high hardness. , the effect of good wear resistance

Inactive Publication Date: 2012-07-04
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, dentin and enamel are very different in structure and composition. Enamel has very little organic matter and is composed of numerous dense enamel columns and a small amount of column interstitium. Dentin is slightly less mineralized than enamel, and organic matter is about Accounting for about 30%, it is composed of matrix and dentinal tubules. There are cell processes and dentinal tubule fluid from odontogenic cells in the dentinal tubules, so as to carry out nutrient metabolism, so the method adopted in this patent application cannot be used in Fabrication of biomimetic hydroxyapatite coatings on dentin

Method used

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  • Dentin surface bionic hydroxyapatite coating preparation method
  • Dentin surface bionic hydroxyapatite coating preparation method
  • Dentin surface bionic hydroxyapatite coating preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation process of the biomimetic hydroxyapatite coating on the surface of dentin is as follows:

[0035] A. Put the flaky dentin sample in the root of the tooth into a phosphoric acid solution with a mass fraction of 37% for pretreatment, and treat it for 30 seconds. The scanning electron micrograph of the treated dentin surface is shown in figure 1 , and then put the dentin sample into a 10% sodium hypochlorite solution for deproteinization treatment, and the deproteinization treatment temperature is 20°C. B. Put the dentin sample treated in step A into the electrolyte gel for electrolysis. Dissolve 75.6 mg of calcium nitrate in distilled water to a concentration of 3.2 x 10 -3 M solution, and then 22mg of ammonium dihydrogen phosphate was dissolved in distilled water to prepare 1.96×10 -3 M solution, according to the calcium-phosphorus molar ratio of 1.67, the calcium-phosphorus-containing solution is mixed, the calcium ion mass concentration is 0.01%, and ...

Embodiment 2

[0038] The preparation process of the biomimetic hydroxyapatite coating on the surface of dentin in this embodiment is as follows:

[0039] A. Put the flaky dentin sample in the crown part into 6% citric acid solution for pretreatment, and treat it for 2 minutes. The scanning electron microscope picture of the treated dentin surface is shown in figure 2 , and then put the dentin sample into a 10% sodium hypochlorite solution for deproteinization treatment, and the deproteinization treatment temperature is 30°C.

[0040] B. Put the dentin sample treated in step A into an electrochemical device for electrolysis, dissolve 133.2 mg of calcium chloride in distilled water, and prepare a concentration of 1.2×10 -3 M solution, and then 125.4 mg of potassium dihydrogen phosphate was dissolved in distilled water to prepare 0.72 × 10 -3 M solution, according to the calcium-phosphorus molar ratio of 1.67, the calcium-phosphorus-containing solution is mixed, the calcium ion mass concentr...

Embodiment 3

[0043] The preparation process of the biomimetic hydroxyapatite coating on the surface of dentin in this embodiment is as follows:

[0044] A, put the tooth crown flake dentin sample into the phosphoric acid solution of mass fraction 37% to carry out pretreatment, process 60s, then put the dentin sample into the mass fraction of 10% sodium hypochlorite solution, carry out deproteinization treatment, so The deproteinization treatment temperature is 30°C.

[0045] B. Put the dentin sample treated in step A into the electrolyte gel for electrolysis. Take 55.5 mg of calcium chloride and dissolve it in distilled water to prepare a concentration of 2.5×10 -2 mol / L solution, then take 40.8 mg of potassium dihydrogen phosphate and dissolve it in distilled water to prepare a concentration of 1.5×10 -2 mol / L solution, mix the calcium-containing phosphorus solution according to the calcium-phosphorus molar ratio of 1.67, the calcium ion concentration is 0.3%, then add 0.07% porcine ame...

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Abstract

The invention discloses a dentin surface bionic hydroxyapatite coating preparation method, which relates to a method for preparing a bionic hydroxyapatite coating having a certain shape and a certain structure on the surface of decayed and sensitive dentin by using an electrochemical process. The method comprises the following steps: pretreating a dentin sample; subjecting the dentin sample to deproteinization treatment; and placing the sample in electrolyte gel for electrolysis, wherein the electrolyte gel comprises calcium and phosphorus solution, pig ameloblastin and hydroxymethyl cellulose, the pH value of the electrolyte gel is between 5.5 and 7.4, the treatment temperature is 30 to 55 DEG C, the current density is 0.3 to 2MA / cm<2>, and the treatment time is 30 minutes to 1 hour. When the method is used, the bionic coating of which the thickness is about 2 to 20 mu m is prepared, and the coating has the same mechanical performance as nature enamel and can combine with substrate dentin tightly. The coating has higher hardness and higher wear resistance and can restore dentin caries in early period, fill dentinal tubules and relieve dentine hypersensitivity.

Description

technical field [0001] The invention relates to a method for preparing a hydroxyapatite coating, in particular to a method for preparing a bionic hydroxyapatite coating on the surface of dentin. Background technique [0002] Teeth are composed of four parts: enamel, dentin, cementum and pulp. Dentin is the main part of the tooth, located in the inner layer of enamel and cementum. It is light yellow in color and has a lower degree of calcification and hardness than enamel. Slightly higher than bone tissue, the central pulp cavity is filled with pulp tissue, which is composed of matrix and dentin tubules, about 70% of inorganic salts, mainly hydroxyapatite, about 30% of organic matter, mainly collagen . [0003] Dental caries and dentin sensitivity are the most common diseases that occur in dentin. Dentin caries is mainly manifested as root caries, and the prevalence rate of root caries in my country aged 65-74 is 63.6%. Dentin hypersensitivity refers to short, sharp pains ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61C13/09A61K6/033A61K6/838
Inventor 陈新梅王盼盼郭蓝李鑫申思敏黄定明尹仕海郝玉庆
Owner SICHUAN UNIV
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