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Succinyl-chitosan/polyvinyl alcohol composite sponge and preparation method thereof

A technology of carboxybutyryl chitosan and polyvinyl alcohol, applied in the field of carboxybutyryl chitosan/polyvinyl alcohol composite sponge and its preparation, to achieve good biocompatibility, promote immune mechanism reconstruction, and good biocombination Effect

Active Publication Date: 2011-02-16
山东医正源生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are few reports on polyvinyl alcohol porous sponge at home and abroad, mainly focusing on the research on pure polyvinyl alcohol sponge, and there is no report on carboxybutyryl chitosan / polyvinyl alcohol porous sponge

Method used

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  • Succinyl-chitosan/polyvinyl alcohol composite sponge and preparation method thereof
  • Succinyl-chitosan/polyvinyl alcohol composite sponge and preparation method thereof
  • Succinyl-chitosan/polyvinyl alcohol composite sponge and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0025] The preparation method of carboxybutyryl chitosan / polyvinyl alcohol composite sponge comprises the steps:

[0026] Polyvinyl alcohol and carboxybutyryl chitosan are according to the percentage by weight of each raw material: polyvinyl alcohol 10wt% with a degree of polymerization of 2000, carboxybutyryl chitosan 1wt%, water 65wt%, add in the there-necked bottle, in After condensing and refluxing at 100°C for 100 minutes, pour the solution into a beaker, add 9wt% sulfuric acid, 12wt% formaldehyde and 3wt% sodium bicarbonate, stir and mix evenly, pour the blend into a mold, and heat it in an oven at 60°C After molding for 8 hours, the carboxybutyryl chitosan / polyvinyl alcohol composite sponge was obtained. The resulting carboxybutyryl chitosan / polyvinyl alcohol composite sponge had an elongation at break of 327% and a water absorption rate of 1561%. The pore structure of the resulting carboxybutyryl chitosan / polyvinyl alcohol composite sponge is shown in figure 2 . f...

Embodiment 2

[0028] The preparation method of carboxybutyryl chitosan / polyvinyl alcohol composite sponge comprises the steps:

[0029] Put polyvinyl alcohol and carboxybutyryl chitosan according to the percentage by weight of each raw material: 10wt% of polyvinyl alcohol with a degree of polymerization of 2000, 1.5wt% of carboxybutyryl chitosan, and 64.5wt% of water, and add them to the three-necked bottle , After condensing and refluxing at 100°C for 100 minutes, pour the solution into a beaker and add 9wt% sulfuric acid, 12wt% formaldehyde and 3wt% sodium bicarbonate, stir and mix evenly, pour the blend into a mold, and place in an oven for 60 ℃ thermoforming for 8 hours to obtain carboxybutyryl chitosan / polyvinyl alcohol composite sponge. The resulting carboxybutyryl chitosan / polyvinyl alcohol composite sponge had an elongation at break of 379% and a water absorption rate of 1532%. The pore structure of the resulting carboxybutyryl chitosan / polyvinyl alcohol composite sponge is shown i...

Embodiment 3

[0031] The preparation method of carboxybutyryl chitosan / polyvinyl alcohol sponge comprises the steps:

[0032] Polyvinyl alcohol and carboxybutyryl chitosan are according to the percentage by weight of each raw material: polyvinyl alcohol 10wt% that the degree of polymerization is 2000, carboxybutyryl chitosan 2wt%, water 64wt%, add in the there-necked bottle, in After condensing and refluxing at 100°C for 100 minutes, pour the solution into a beaker, add 9wt% sulfuric acid, 12wt% formaldehyde and 3wt% sodium bicarbonate, stir and mix evenly, pour the blend into a mold, and heat it in an oven at 60°C After molding for 8 hours, the carboxybutyryl chitosan / polyvinyl alcohol composite sponge was obtained. The resulting carboxybutyryl chitosan / polyvinyl alcohol composite sponge had an elongation at break of 335% and a water absorption rate of 1468%. The pore structure of the resulting carboxybutyryl chitosan / polyvinyl alcohol composite sponge is shown in Figure 4 . Figure 4 ...

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Abstract

The invention relates to a succinyl-chitosan / polyvinyl alcohol composite sponge. The composite sponge is prepared with succinyl-chitosan and polyvinyl alcohol as the raw materials and comprises the following raw materials by weight: 0.5-2% of succinyl-chitosan, 9-10% of polyvinyl alcohol, 9-13% of inorganic acid, 10-17% of formaldehyde, 3-5% of foaming agent and the balance water. A preparation method of the composite sponge comprises thermal dissolution, acetalization and foaming of polyvinyl alcohol and compositing of polyvinyl alcohol and succinyl-chitosan. During preparation, the polyvinyl alcohol which undergoes complete alcoholysis or incomplete alcoholysis and has degree of polymerization of 1700-2000 is selected as the raw material, the succinyl-chitosan and the polyvinyl alcohol are mixed in water and heated and dissolved, then acid, formaldehyde and the foaming agent are added to the mixture to be blended and the mixture is heated and formed in an oven, thus obtaining the composite sponge. The method can prepare the composite sponge with higher water absorbing capacity, better flexibility and viscoelasticity and good biocompatibility and the advantages of low cost, environmental protection and simple process, and the obtained material can be applied to treating wound cavity infection, burns, skin grafting, etc.

Description

technical field [0001] The invention relates to the field of polymer material science, and also belongs to the field of natural polymers, in particular to a carboxybutyryl chitosan / polyvinyl alcohol composite sponge and a preparation method thereof. Background technique [0002] Chitosan has good biocompatibility, bioadhesion and various biological activities. It is non-toxic and non-immune. It can be biodegraded by various enzymes in the body. The degradation products are non-toxic and can be completely absorbed by organisms. Ideal carrier for interpretation. However, chitosan is only soluble in acidic aqueous solution, which limits its application range. Carboxybutyryl chitosan is a water-soluble derivative of chitosan. Due to the introduction of carboxybutyryl groups, the water solubility is greatly improved, so that it has good biocompatibility and the function of promoting wound healing. [0003] Polyvinyl alcohol has good tissue compatibility and mechanical propertie...

Claims

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Application Information

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IPC IPC(8): A61L27/60C08J9/04C08F16/06A61L15/28C08F8/28A61L15/24C08J9/08C08L29/14C08L5/08
Inventor 樊李红周月
Owner 山东医正源生物医药科技有限公司
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