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New application of valeriana jatamansi jones total flavonoids

A technology of spider incense and total flavonoids, applied in the field of preparation of drugs for treating liver cancer or fibrosarcoma

Inactive Publication Date: 2011-11-30
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The prior art discloses that the spider-like iridoids have anti-tumor activity, its total flavonoids have anti-inflammatory and antibacterial effects, and the alcohol extract with a total flavonoid content of 3.47% has anti-colon cancer effects, but there is no It is reported in the literature that the total flavonoids of spider incense is used for the treatment of liver cancer or fibrosarcoma

Method used

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  • New application of valeriana jatamansi jones total flavonoids

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Embodiment 1

[0033] Embodiment 1 The preparation of the total flavonoids of spider incense of the present invention

[0034] Take 200g of spider incense, crush the spider incense medicinal material, use 60-90°C petroleum ether to reflux and degrease, and use a material-to-liquid ratio of 1:20 (g·ml -1) in 65% ethanol, soaked for 12 hours, ultrasonically extracted 3 times, 40 minutes each time, suction filtered, combined filtrates, recovered ethanol under reduced pressure until there was no alcohol smell, diluted with an appropriate amount of water, and suction filtered to obtain a prepared solution. The above preparation solution was 3.42mg·ml -1 Loading concentration, 2.4BV h -1 The adsorption flow rate is through HPD600 macroporous resin, and the resin column after adsorption is first eluted with 3BV water, and then 4BV80% ethanol is used for 2.4BV·h -1 Flow rate elution, collect 80% ethanol elution part, recover ethanol, obtain concentrated solution, dry, obtain the total flavonoids o...

Embodiment 2

[0036] Example 2 The extraction method investigation test of the total flavonoids of spider incense of the present invention

[0037] Taking the content of total flavonoids in the extract as an index, the five extraction factors of ethanol concentration, extraction time, extraction times, soaking time, and solid-liquid ratio were investigated by single factor test, and finally the extraction conditions were investigated by orthogonal test. factors to filter. Wherein, the assay method of total flavonoids is according to Example 4.

[0038] 1. Investigation on the solvent Accurately weigh three 4.00g portions of degreased spider incense in a Erlenmeyer flask, add 20BV of water, methanol, and 60% ethanol solution as required, and soak for 24 hours. According to the above extraction method, extract three times, 30min each time, configure the sample solution, and measure the absorbance. Test shows that it is advisable to make solvent with ethanol, the result sees figure 1 .

[...

Embodiment 3

[0055] Embodiment 3 Purification process investigation of the total flavonoids of spider incense of the present invention

[0056] 1. Investigation of macroporous resin types

[0057] Adopt static adsorption-desorption method, comprehensively consider the adsorption capacity and desorption rate of the selected resin, and screen out the best resin. The test shows that HPD600 and HPD500 have large static adsorption capacity, while HPD600 has a very high resolution rate, so it is the first choice. HPD600 macroporous resin. The results are shown in Table 4.

[0058] Table 4 macroporous resin screening data

[0059]

[0060] 2. Investigation of macroporous resin purification process

[0061] (1) Investigation of the concentration of the sample solution: 1.71, 2.56, 3.42, 4.27 mg·ml -1 The concentration of the preparation solution was investigated, and the adsorption capacity of the resin was used as an index. The adsorption capacity of each concentration was 67.94, 87.20, 10...

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Abstract

The invention provides new application of valeriana jatamansi jones total flavonoids, in particular application in preparing a medicament for treating liver cancer or fibrosarcoma. The invention also provides a medicinal composition for treating liver cancer or fibrosarcoma. The valeriana jatamansi jones total flavonoids have remarkable inhibiting effect on the growth of tumors in mice inoculatedwith liver cancer H22 and fibrosarcoma S180 so as to show that the valeriana jatamansi jones total flavonoids have obvious effect of resisting the liver cancer and the fibrosarcoma and provide a new medicament selection for clinic.

Description

technical field [0001] The invention relates to a new application of the total flavonoids of spider incense, in particular, an application in the preparation of medicines for treating liver cancer or fibrosarcoma, and belongs to the field of medicines. Background technique [0002] Spider incense (Valeriana jatamansi Jones) is the root or rhizome of Valeriana jatamansi Jones, also known as Lian vanilla, Heart leaf valerian, Horseshoe incense, Yangxin lotus, black ginseng, vanilla seed, Leigong seven, etc. Spider incense is a perennial herb that grows in hilltop meadows, forests or streams below an altitude of 2,500 meters. Distributed in Henan, Hubei, Hunan, Sichuan, Guizhou, Yunnan, Tibet, Shaanxi and other places, it is used as medicine with roots and rhizomes. It tastes pungent, slightly bitter, and warm in nature. Efficacy: Indications for abdominal distension and pain, vomiting and diarrhea, infantile malnutrition, wind-cold-damp arthralgia, beriberi edema, irregular m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P35/00A61P43/00A61K125/00
Inventor 闫智勇张天娥肖婷潘玲珍张占平左长英
Owner SOUTHWEST JIAOTONG UNIV
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