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Method for recrystallizing cefuroxime sodium

A cefuroxime sodium and recrystallization technology, which is applied in the field of medicine, can solve the problems of being unsuitable for the production of sterile raw materials, deepening the color of cefuroxime sodium, and cumbersome operations, etc., achieving low cost, high recrystallization efficiency, and increased yield. rate effect

Inactive Publication Date: 2012-07-18
石药集团中诺药业(石家庄)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method is cumbersome to operate, and seed crystals need to be added during the process, which is not suitable for the production of sterile raw materials
Chinese patent CN101054386 discloses a synthetic method of cefuroxime sodium, which includes the refining of cefuroxime sodium, specifically adding acetone dropwise to the aqueous solution of the crude product of cefuroxime sodium to precipitate solids, which is easy to operate, but Acetone will deepen the color of the precipitated cefuroxime sodium, especially unsuitable for crude cefuroxime sodium with unqualified color grade

Method used

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  • Method for recrystallizing cefuroxime sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] a. Preparation of crude solution: In a 500mL round bottom flask, add 200mL of water for injection at 15°C, 35.0g of crude cefuroxime sodium raw material (color grade No. 6), stir until all the solids are dissolved, add 1.1g of activated carbon, and control the temperature of the solution at 10-15°C, stir for 30 minutes, filter, wash the filter cake with 10mL water for injection at 15°C, combine the filtrates, add 10% acetic acid aqueous solution dropwise thereto to adjust the pH value to 6.5, and set aside;

[0023] b. Preparation of crystallization solvent: prepare 1015 mL of mixed liquid with methanol and acetone at a volume ratio of 0.5:10, stir evenly, and set aside;

[0024] c. Crystallization: Add the crude product solution obtained in step a dropwise to the crystallization solvent obtained in step b, and stir while adding, and a white solid is precipitated. After the dropwise addition, continue to add 560 mL of acetone dropwise. The temperature of the solution is ...

Embodiment 2

[0027] a. Preparation of crude solution: In a 500mL round bottom flask, add 200mL of water for injection at 15°C, 35.0g of crude cefuroxime sodium raw material (color grade No. 6), stir until all the solids are dissolved, add 1.1g of activated carbon, and control the temperature of the solution 10-15°C, stir for 30 minutes, filter, wash the filter cake with 10mL water for injection at 15°C, combine the filtrates, add 10% acetic acid aqueous solution dropwise thereto to adjust the pH value to 6.7, and set aside;

[0028] b. Preparation of crystallization solvent: prepare 1015 mL of mixed liquid with methanol and acetone in a volume ratio of 1:10, stir evenly, and set aside;

[0029] c. Crystallization: Add the crude product solution obtained in step a dropwise to the crystallization solvent obtained in step b, and stir while adding, and a white solid is precipitated. After the dropwise addition, continue to add 560 mL of acetone dropwise. The temperature of the solution is contr...

Embodiment 3

[0032] a. Preparation of crude solution: In a 500mL round bottom flask, add 200mL of water for injection at 10°C, 35.0g of crude cefuroxime sodium raw material (color grade No. 7), stir until all the solids are dissolved, add 1.1g of activated carbon, and control the temperature of the solution 10-15°C, stir for 30 minutes, filter, wash the filter cake with 10mL water for injection at 10°C, combine the filtrates, add 20% acetic acid aqueous solution dropwise to adjust the pH value to 7.0, and set aside;

[0033] b. Preparation of crystallization solvent: prepare 1015mL of mixed liquid with methanol and acetone at a volume ratio of 1.5:10, stir evenly, and set aside;

[0034] c. Crystallization: Add the crude product solution obtained in step a dropwise to the crystallization solvent obtained in step b, stir while adding, and a white solid is precipitated. After the dropwise addition, continue to add 560 mL of acetone dropwise. The temperature of the solution is controlled durin...

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Abstract

The invention relates to a method for recrystallizing cefuroxime sodium, which is used for solving the problem of the refining of cefuroxime sodium raw material medicaments with darker colors. In the technical scheme, white crystalline powder recrystallized by the cefuroxime sodium is prepared by the following four steps of: a, preparing crude product solution; b, preparing a crystallization solvent; c, crystallizing; and d, discharging. By the method, the yield is over 83 percent, and the color level and the pH value of final products meet the pharmacopoeial standard; and the method is suitable for recrystallizing the raw material medicaments with unqualified color levels.

Description

technical field [0001] The invention relates to a method for recrystallizing cefuroxime sodium, which belongs to the technical field of medicine. Background technique [0002] Cefuroxime sodium (Sodium cefuroxime) is a second-generation injection of cephalosporin anti-infective drugs, developed by the British GlaxoSmithKline company, first listed in 1978. This product has a high antibacterial effect on Staphylococcus aureus, Streptococcus, Meningococcus, Influenza Bacillus, Klebsiella, Escherichia coli, Proteus mirabilis, Salmonella, Shigella, etc., and can resist β-lactamase. Penicillin-resistant Staphylococcus aureus is effective, and it is mainly used clinically for respiratory tract infections, pyelonephritis, urinary tract infections, and infections of bones, joints, ear, nose, throat, and soft tissues caused by sensitive bacteria. [0003] The chemical name of cefuroxime sodium is (6R,7R)-7-[2-furyl(methoxyimino)acetamido]-3-carbamoyloxymethyl-8-oxo-5-thia-1 -Sodium ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D501/34C07D501/12
Inventor 胡艳茹王国胜胡利敏谭清钟董伟昌王翠静
Owner 石药集团中诺药业(石家庄)有限公司
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