Preparation method and use of Syringa pubescens bark extract
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A technology of clove and its extract, which is applied in the research and development field of its pharmaceutical products, and can solve the problems that the research on the antioxidant activity of clove bark has not been reported yet.
Inactive Publication Date: 2011-02-09
SHANDONG UNIV AT WEIHAI
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Problems solved by technology
At present, the research on antioxidant has become a hot spot, but the research on the antioxidant activity of clove bark has not been reported
Method used
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Embodiment 1
[0019] (1) Get 100 g of the 40-mesh powder of the clove bark, extract it with 6 times the amount of 70% ethanol at room temperature for 8 hours, and let it stand and filter;
[0020] (2) Repeat the above steps with 8 times the amount and 6 times the amount of 70% ethanol respectively for the filter residue, and sonicate for 30 minutes;
[0021] (3) merging the filtrate, reclaiming the solvent to obtain the total extract;
[0022] (4) Extract the total extract 3 times with sherwood oil, ethyl acetate and water-saturated n-butanol respectively;
[0024] (6) (5) petroleum ether layer, ethyl acetate layer and n-butanol layer extract are concentrated under reduced pressure respectively, and freeze-dried to obtain clove bark petroleum ether layer extract, ethyl acetate layer extract, n-butanol layer extract.
[0025] (7) The extracts from (6) the petroleum ether layer, the et...
Embodiment 2
[0027] (1) Get 200 g of the 40-mesh powder of the clove bark, extract it with 8 times the amount of 70% ethanol at room temperature for 10 hours, and let it stand and filter;
[0028] (2) Repeat the above steps with 8 times the amount and 6 times the amount of 70% ethanol respectively for the filter residue, and sonicate for 30 minutes;
[0029] (3) merging the filtrate, reclaiming the solvent to obtain the total extract;
[0030] (4) Extract the total extract 3 times with sherwood oil, ethyl acetate and water-saturated n-butanol respectively;
[0032] (6) (5) petroleum ether layer, ethyl acetate layer and n-butanol layer extract are concentrated under reduced pressure respectively, and freeze-dried to obtain clove bark petroleum ether layer extract, ethyl acetate layer extract, n-butanol layer extract.
[0033] (7) The extracts from (6) the petroleum ether layer, the e...
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Abstract
The invention belongs to the technical field of medicinal product research and development. The invention relates to a preparation method and use of Syringa pubescens bark extract. The method comprises: leaching 40-mesh Syringa pubescens bark powder with 70-percent ethanol in an amount which is 6 to 8 times that of the Syringa pubescens bark powder at room temperature for 8 to 10 hours, standing and filtering; leaching the filter residue with 70-percent ethanol in an amount which is 8 times that of the filter residue, leaching the filter residue with 70-percent ethanol in an amount which is 6 times that of the filter residue, performing ultrasonic treatment for 30 minutes, combining filtrate, recovering solvent and obtaining total extract; extracting the total extract with petroleum ether, ethyl acetate, water saturated n-butyl alcohol respectively at three times; and combining the petroleum ether layer extract solution, the ethyl acetate extract solution and the n-butyl alcohol extract solution, concentrating under vacuum, performing freeze drying, and obtaining the petroleum ether layer extract, ethyl acetate extract and n-butyl alcohol extract of the Syringa pubescens bark. The product of the invention has a remarkable removing effect on hydroxyl radicals, can be developed into a natural antioxidant medicament to be used as a substitute for synthetic antioxidant in treating diseases caused by an overlarge amount of radicals in the body.
Description
technical field [0001] The invention belongs to the technical field of research and development of pharmaceutical products. The invention relates to a preparation method and application of a clove bark extract. Background technique [0002] Syringa Pubescens Turcz., also known as Qiaoling flower, sparrow flower, and hairy lilac, is a plant of the genus Syringa in the family Oleaceae. It is distributed in Henan, Hebei, Shaanxi, Shanxi, Gansu and other places in my country. It grows in Mountains, valleys or cliffs at an altitude of 800-2400m. The folks have known its medicinal value for a long time. They used to pick its flowers and fruits to make tea for drinking. It has anti-inflammatory, antitussive, and curative effects on hepatitis and cirrhosis, but it has not been included in the pharmacopoeia so far. At present, there are few reports on the research on the plant of Lilac microphylla at home and abroad, and the research on the bark is even rarer. [0003] Free radical...
Claims
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