Plant soft capsule material and preparation method thereof

Abstract

The invention provides a plant soft capsule material. The capsule material is at least prepared from the following raw materials in percentage by weight: 0.01 to 20 percent of flaxseed gum, 0.02 to 20 percent of thickening agent, 0.02 to 20 percent of film forming agent, 0.05 to 20 percent of plasticizer and the balance of water. The invention also provides a method for preparing the plant soft capsule material. A soft capsule prepared from the plant soft capsule material has the advantages of high medicament stability, high elasticity, high toughness, long shelf life and the like, is not limited by religion and taboo and can be popularized and applied all over the world.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a vegetable soft capsule material and a preparation method thereof. Background technique [0002] At present, gelatin is generally used as the main raw material for the production of soft capsule shells. It is mainly derived from animal skin, tendons, bones, etc., and is a protein that is partially hydrolyzed from the collagen in the connective tissue or epidermal tissue of animals; the reason for choosing Gelatin is used as the capsule material because it has good thermal reversibility and improves the disintegration rate and dissolution rate of the drug to a certain extent compared with traditional capsules. However, through long-term clinical application, it has been found that the soft capsule material made of gelatin as the main raw material still has the following problems: [0003] First, because gelatin is a proteinaceous substance, it contains a large amount of amino gr...

AI Technical Summary

Problems solved by technology

[0003] First, because gelatin is a proteinaceous substance, it contains a large amount of amino groups, and the contents of soft capsules are mostly drug molecules with aldehyde groups. The aldehyde group inside the drug molecule will undergo a cross-linking reaction with the amino group in gelatin. After the reaction, some drug molecules will be denatured, which will cause some effective drug ingredients to change. It is impossible to determine how harmful it will be. On the other hand, after the cross-linking reaction occurs, a cross-linked film will be formed, which will present a coating state on the outside of the effective drug molecule. If the effective drug molecule enters the human body, if it is to be released, it must first be released. The dissolution of the capsule shell is precisely due to the formation of the cross-linked film. After the soft capsule enters the human body, not only the soft capsule shell needs to be dissolved, but also the above-mentioned cross-linked film must be dissolved, which prolongs the dissolution time and affects the soft capsule. Disintegration rate and dissolution rate of its active drug

[0004] Second, gelatin is an animal material. Islamic countries, Buddhism, and vegetarians are all disgusted with gelatin capsules, which makes it impossible for patients with the above religious beliefs to take soft capsules, which also limits the application of gelatin soft capsules to a large extent. and promotion

Due to the high viscosity of linseed gum and excellent emulsifying properties, the soft capsule shell made of linseed gum is too soft, but lacks the toughness (strength) that can be used as a soft capsule material. Therefore, in the prior art , there has never been an example of using flaxseed gum as a soft capsule material

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