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Traditional Chinese medicine extraction method by combined application of full biomimetic digestion technology and cell membrane biomimetic solid phase extraction technology

A technology of bionic digestion and joint application, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of large solution volume, inability to take orally, poor taste, etc., achieve mild reaction conditions, keep the original medicinal effect

Active Publication Date: 2011-12-14
MINNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing bionic extraction technology only stops at extracting the active ingredients in traditional Chinese medicine into bionic liquids such as stomach and intestines, and the above-mentioned bionic extraction liquid has problems such as large solution volume, poor taste, and prone to gastrointestinal discomfort, etc. It can be used directly orally like a water decoction; of course, it can also be concentrated or dried, but because the above-mentioned bionic liquid contains a large number of biological enzymes and a series of complex compounds, during the heating process, The active ingredients contained in it are prone to side reactions (such as hydrolysis reactions, etc.), resulting in a decrease in the content of active ingredients

Method used

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  • Traditional Chinese medicine extraction method by combined application of full biomimetic digestion technology and cell membrane biomimetic solid phase extraction technology
  • Traditional Chinese medicine extraction method by combined application of full biomimetic digestion technology and cell membrane biomimetic solid phase extraction technology
  • Traditional Chinese medicine extraction method by combined application of full biomimetic digestion technology and cell membrane biomimetic solid phase extraction technology

Examples

Experimental program
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Effect test

Embodiment 1

[0023] According to the traditional decoction method to obtain the decoction of traditional Chinese medicine, weigh 300g of Astragalus powder, put it into a 600mL beaker, add 400mL of ultra-pure water each time, heat to boiling and keep it at a slight boil for about 1h, decoct three times, combine three decoctions solution, heated and concentrated, and filtered with a 0.45 μm filter to 1000 mL to obtain 1000 mL of decoction of Radix Astragali;

[0024] Take 250mL decoction of Astragalus membranaceus and add it into a volumetric flask, then add 5mL simulated saliva to it, shake at a constant temperature at 37°C for 5min; then add 150mL simulated gastric juice, continue shaking at 37°C for 2h, and obtain 405mL in vitro gastric biomimetic digestive juice ;

[0025] Add 195mL of duodenum simulated solution and 75mL of simulated bile to the obtained 405mL of astragalus water-decocted liquid exogastric biomimetic digestion solution, continue shaking at 37°C for 7 hours, remove the s...

Embodiment 2

[0029] Obtain Shuanghuanglian water decoction according to the traditional decoction method, weigh 375g of honeysuckle, 375g of Scutellaria baicalensis and 750g of forsythia, put them into a 600mL beaker, add 400mL of ultrapure water each time, heat to boiling and keep boiling slightly for about 1 hour, decoct Boil three times, combine three times of decoction, heat and concentrate, filter with 0.45 μm membrane filter to 1000mL, obtain Shuanghuanglian water decoction 1000mL;

[0030] Take 250mL of Shuanghuanglian water decoction and put it into a volumetric flask, add 2.5mL of simulated saliva to it, and shake at a constant temperature at 36°C for 6 minutes; then add 125mL of simulated gastric juice, continue to shake at 36°C for 4 hours, and obtain 377mL of gastric biomimetic digestive juice in vitro ;

[0031]Add 178mL of duodenal simulated solution and 70mL of simulated bile to the 377mL in vitro bionic gastric digestion solution obtained above, continue shaking at 36°C for...

Embodiment 3

[0035] Accurately weigh 2.50g of peach kernel powder into a 1000mL volumetric flask, add 7.5mL of saliva, shake in a water bath at a constant temperature of 38°C for 3 minutes, add 270mL of gastric juice, and continue to shake at 38°C for 1 hour to obtain gastric biomimetic digestive juice of peach kernel powder, pour into it Add 332.5mL of duodenal juice and 140mL of bile, continue to shake at 38°C for 5h, and filter through a 0.45μm filter membrane to obtain 750mL of gastrointestinal bionic digestion solution of peach kernel powder, which is stored at 4°C until use.

[0036] Take 0.250 mg of egg yolk lecithin, dissolve it in 5.00 mL of chloroform to obtain a chloroform solution of egg yolk lecithin; transfer the above solution into a stoppered round-bottomed flask, and vacuum and rotate it on a rotary evaporator for 10 minutes to form Uniform multi-layer lipid film, and then fill it with nitrogen to prevent the multi-layer lipid film from being oxidized; add 25.00mL of the wh...

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Abstract

The present invention provides a method for extracting traditional Chinese medicines combined with full bionic digestion technology and cell membrane bionic solid-phase extraction technology. Add the corresponding bionic digestive juice (simulated saliva, simulated gastric juice, simulated duodenal juice and simulated bile), and then reasonably arrange the digestion time of each stage according to the emptying time of different dosage forms of traditional Chinese medicine in the human digestive organs. The whole bionic digestive juice is obtained; then the distribution and absorption of the whole bionic digestive juice in the human gastrointestinal tract is simulated by the monolayer liposome-water distribution system, and the monolayer liposome loaded with the active ingredients of traditional Chinese medicine is obtained. The invention combines the full bionic digestion technology and the cell membrane bionic solid-phase extraction technology, has mild reaction conditions, and has the beneficial effect of maintaining the conformation of natural products and the original efficacy of active ingredients.

Description

technical field [0001] The invention relates to a method for extracting traditional Chinese medicines, in particular to a method for extracting traditional Chinese medicines by combining full bionic digestion technology and cell membrane bionic solid-phase extraction technology. Background technique [0002] The composition of traditional Chinese medicine is extremely complex, and various active ingredients cooperate with each other and act synergistically after entering the human body, and then play a role in the treatment of diseases. Traditional purification and separation technologies (such as decoction, reflux, immersion, percolation, etc.) , multi-effect film concentration and drying technology, vacuum belt drying technology, computer control technology, etc.) all use "pure" and "traditional" physical and chemical means, which have nothing to do with the synergy of the active ingredients of traditional Chinese medicine absorbed into the human body, so they are easy to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/00
Inventor 李顺兴郑凤英
Owner MINNAN NORMAL UNIV
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