Nimodipine ophthalmic preparation and preparation method thereof

Abstract

The invention relates to a drug effective ingredient, in particular to a nimodipine (NMD) ophthalmic preparation and a preparation method thereof. The nimodipine ophthalmic preparation comprises a medicinal auxiliary and an effective quantity of nimodipine ingredient used for protecting optic nerves and dispersed to the auxiliary. In the embodiment of the invention, the NMD ophthalmic preparation comprises a 0.09% NMD eye drop and a 0.3% NMD eye ointment. The preparation method of the 0.09% NMD eye drop comprises the following steps of: adding 0.9 g of NMD and 0.3 g of ethylparaben into 50 ml of tween-80, and uniformly stirring, adding 600 ml of double buffer solution, heating to dissolve, adding the double buffer solution to 1000 ml, and adjusting the pH value to 6.7-7.2; filtering, sterilizing by flowing stream, and canning. The preparation method of the 0.3% NMD eye ointment comprises the following steps of: placing 3g of nimodipine in a sterilizing mortar in sterile operation, adding 5 ml of sterilized liquid paraffin, grinding into a fine paste, adding into 0.3g of ethylparaben and 50 ml of tween-80, uniformly stirring, adding an eye ointment matrix several times, uniformly grinding while adding till being 1000g, and subpackaging in a sterile way. The nimodipine ophthalmic preparation has the advantages of high efficiency, small side effect and convenient medication, and has good application prospect in the prevention and treatment of eye diseases, especially the protection of glaucoma optic nerves.

Description

Technical field: [0001] The invention relates to an active ingredient of medicine, nimodipine ophthalmic preparation and a preparation method thereof, which are mainly used for the protective treatment of glaucoma optic nerve. Background technique: [0002] In recent years, calcium channel blockers (Calcium Channel Blockers, CCB) in the treatment of primary glaucoma have received increasing attention in ophthalmology. On the one hand, the increasing number of glaucoma patients is a problem that must be paid attention to in the prevention of blindness: some patients with primary glaucoma, such as primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG), have a hidden course of disease, and most patients with progressive visual field Traditional anti-glaucoma drug treatment cannot completely control the progression of the disease, resulting in serious visual function damage. Although there is no relevant epidemiological statistics in China, with the development of...

AI Technical Summary

Problems solved by technology

On the one hand, the increasing number of glaucoma patients is a problem that must be paid attention to in the prevention of blindness: some patients with primary glaucoma, such as primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG), have a hidden course of disease, and most patients with progressive visual field Traditional anti-glaucoma drug treatment can not completely control the progression of the disease, resulting in serious damage to visual function

[0004] However, NMD is fat-soluble and not easy to penetrate the vascular barrier. Large-scale application can also cause blood pressure to change and poor microcirculation, leading to further damage, so the systemic pharmacological pathway is limited.

The use of topical ophthalmic application can not only reduce the side effects of large doses of medication throughout the body, but also maintain a certain local concentration. According to the new research of Shandong Provincial Medical and Health Science and Technology Information Institute, there are no relevant reports at home and abroad.

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