Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound telmisartan amlodipine besylate medicinal composition and preparation method thereof

A kind of technology of amlodipine besylate and amlodipine besylate solid, applied in telmisartan amlodipine besylate besylate pharmaceutical composition and its new preparation field, can solve the problem of not proposing besylate Amlodipine dissolution and other issues

Active Publication Date: 2011-01-19
天津汉一医药科技有限公司
View PDF2 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] CN101052381A discloses adopting tablet technology to prepare this pharmaceutical preparation, but does not propose to adopt solid dispersion technology to solve the technical problem that the dissolution rate of amlodipine besylate is low

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound telmisartan amlodipine besylate medicinal composition and preparation method thereof
  • Compound telmisartan amlodipine besylate medicinal composition and preparation method thereof
  • Compound telmisartan amlodipine besylate medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Tablet prescription composition, each 1000 tablets are composed as follows:

[0088] Particle A

[0089] Amlodipine besylate solid dispersion 43.747g

[0090] Microcrystalline cellulose 62.253g

[0091] Low-substituted hydroxypropyl methylcellulose 12g

[0092] Appropriate amount of water

[0093] Composition of amlodipine besylate solid dispersion

[0094] Amlodipine besylate 6.944g

[0095] Povidone K30 34.720g

[0096] Polysorbate 80 2.083g

[0097] Particle B

[0098] Telmisartan 40g

[0099] Meglumine 12g

[0100] Sodium hydroxide 4g

[0101] Lactose 50g

[0102] Croscarmellose Sodium 10g

[0103] Appropriate amount of water

[0104] Magnesium Stearate 1g

[0105] Preparation Process

[0106] 1) Preparation of amlodipine besylate solid dispersion: Take amlodipine besylate, povidone K30 and polysorbate 80 respectively, add absolute ethanol, stir and dissolve, evaporate under reduced pressure to remove absolute ethanol, Vacuumize, dry overnight, grin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a compound telmisartan amlodipine besylate medicinal composition. The composite is a tablet which is prepared by the following steps: preparing amlodipine besylate into amlodipine besylate solid dispersion by a solid-state dispersion technology; and preparing the amlodipine besylate solid dispersion and telmisartan into the composite. The tablet improves the dissolubility of primary medicine, promotes the medicament to be quickly disintegrated, prevents dissolution influence of meglumine to the amlodipine besylate, simultaneously improves the absorptivity in blood, and improves the bioavailability of the primary medicine. The tablet has excellent curative effect to hypertension symptoms.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a telmisartan amlodipine besylate pharmaceutical composition and a new preparation method thereof. Background technique [0002] Telmisartan [0003] The chemical name is: 4-{[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazol-1-yl]methyl}biphenyl-2 -Carboxylic acid [0004] Molecular formula: C 33 h 30 N 4 o 2 [0005] Molecular weight: 514.62 [0006] Telmisartan is a new antihypertensive drug and a specific angiotensin II receptor (AT type I) antagonist. Compared with other antihypertensive drugs, telmisartan has the following characteristics: specificity of receptor action, significant antihypertensive effect, good diuretic effect, can improve myocardial stenosis, drug safety, and tolerance Good 1 time a day, easy to take. [0007] Amlodipine [0008] The chemical name is: 3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4422A61K31/4184A61K47/38A61K9/20A61P9/12
Inventor 严洁黄欣
Owner 天津汉一医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com