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Chitosan-heparin layer-layer self-assembly small-caliber artificial terylene blood vessel and production method thereof

A layer-by-layer self-assembly and artificial blood vessel technology, applied in packaging, food packaging, pharmaceutical packaging, etc., can solve problems such as immune rejection, inner surface modification, and inability to be used in large-scale clinical applications, and achieve long anticoagulant effect and good anticoagulant effect. Coagulation effect

Inactive Publication Date: 2011-01-12
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent 93101997.4 discloses an artificial vascular cell lining, which has a certain antithrombotic effect, but due to the problems of preparation and storage, it cannot be used in large-scale clinical applications
Chinese patent 99809878.7 involves an allogeneic artificial blood vessel, but there is immune rejection
US Patent 7632306 and European Patent US2010121428 each disclose a space-optimized artificial blood vessel, but the inner surface is not modified

Method used

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  • Chitosan-heparin layer-layer self-assembly small-caliber artificial terylene blood vessel and production method thereof
  • Chitosan-heparin layer-layer self-assembly small-caliber artificial terylene blood vessel and production method thereof
  • Chitosan-heparin layer-layer self-assembly small-caliber artificial terylene blood vessel and production method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Such as figure 1 Shown is a schematic diagram of the artificial blood vessel structure. The layer-by-layer self-assembled small-caliber polyester artificial blood vessel with heparin and chitosan includes a knitted polyester artificial blood vessel 1. The inner wall of the knitted polyester artificial blood vessel 1 is provided with a pre-coagulated coating 2. The inner wall of the gel coat 2 is provided with a self-assembled layer 3 of heparin chitosan, and its production method is as follows:

[0020] (1) Precoagulation treatment of polyester artificial blood vessel:

[0021] Place the knitted polyester artificial blood vessel 1 in a 25wt% human albumin solution (25% albumin is prepared by adding 0.08mmol sodium caprylate and 0.08mmol sodium acetyl tryptophan per 1g protein. The protein concentration is diluted to 25% with water for injection according to the specifications of the finished product. , And properly adjust the pH to 7.40 and control the sodium ion concentra...

Embodiment 2

[0028] Such as figure 1 Shown is a schematic diagram of the artificial blood vessel structure. The layer-by-layer self-assembled small-caliber polyester artificial blood vessel with heparin and chitosan includes a knitted polyester artificial blood vessel 1. The inner wall of the knitted polyester artificial blood vessel 1 is provided with a pre-coagulated coating 2. The inner wall of the gel coat 2 is provided with a self-assembled layer 3 of heparin chitosan, and its production method is as follows:

[0029] (1) Precoagulation treatment of polyester artificial blood vessel:

[0030] Place the knitted polyester artificial blood vessel 1 in a 25wt% human albumin solution (25% albumin is prepared by adding 0.08mmol sodium caprylate and 0.08mmol sodium acetyl tryptophan per 1g protein. The protein concentration is diluted to 25% with water for injection according to the specifications of the finished product. , And adjust the pH value to 7.40 and the sodium ion concentration to be ...

Embodiment 3

[0037] Such as figure 1 Shown is a schematic diagram of the artificial blood vessel structure. The layer-by-layer self-assembled small-caliber polyester artificial blood vessel with heparin and chitosan includes a knitted polyester artificial blood vessel 1. The inner wall of the knitted polyester artificial blood vessel 1 is provided with a pre-coagulated coating 2. The inner wall of the gel coat 2 is provided with a self-assembled layer 3 of heparin chitosan, and its production method is as follows:

[0038] (1) Precoagulation treatment of polyester artificial blood vessel:

[0039] Place the knitted polyester artificial blood vessel 1 in a 25wt% human albumin solution (25% albumin is prepared by adding 0.08mmol sodium caprylate and 0.08mmol sodium acetyl tryptophan per 1g protein. The protein concentration is diluted to 25% with water for injection according to the specifications of the finished product. , And adjust the pH to 7.40 and control the sodium ion concentration belo...

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Abstract

The invention provides a chitosan-heparin layer-layer self-assembly small-caliber artificial terylene blood vessel and a production method thereof. The chitosan-heparin layer-layer self-assembly small-caliber artificial terylene blood vessel is characterized by comprising an artificial knitted terylene blood vessel the inner wall of which is provided with a presetting coating, and the inner wall of the presetting coating is provided with a chitosan-heparin layer-layer self-assembly coating. The invention also provides the production method of the chitosan-heparin layer-layer self-assembly small-caliber artificial terylene blood vessel. The product of the invention is used for by-pass operations of surrounding arteries of a human body as a blood vessel transplanter and improves the short-mid-term patency rate of the artificial blood vessel.

Description

technical field [0001] The invention relates to a heparin-chitosan layer-by-layer self-assembled small-diameter polyester artificial blood vessel and a production method thereof, which are used as a blood vessel graft for bypass surgery of human peripheral arteries to improve the short-term patency rate of the artificial blood vessel. Background technique [0002] With the changes in the diet structure and lifestyle of the Chinese people and the improvement of diagnosis and treatment methods, the incidence of vascular diseases is increasing year by year. Atherosclerotic occlusion is the most common disease of arteries. Patients with end-stage arterial disease often need to undergo arterial bypass surgery. Due to the limited source of autologous blood vessels and immune rejection of allogeneic blood vessels, most of the artificial blood vessel materials currently used in clinical practice are non-degradable polymer materials, mainly including polyethylene terephthalate. Eth...

Claims

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Application Information

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IPC IPC(8): A61L33/10A61L33/12
Inventor 陈斌刘震杰王玉琦符伟国陈枫张祥满卢伟锋
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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