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Detecting method of rehmannia-leaf total-glycoside capsule

A detection method and technology of total glycosides capsules are applied in the directions of capsule delivery, material analysis by observing the influence on chemical indicators, measurement devices, etc., and can solve problems such as the inability to guarantee the effectiveness and safety of clinical treatment.

Active Publication Date: 2011-01-12
SICHUAN MEDCO PHARML
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the drug is a new drug, there is still a lack of specific detection methods and quality standards that can effectively control the production quality of the preparation, so the effectiveness and safety of the drug in clinical treatment cannot be guaranteed.

Method used

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  • Detecting method of rehmannia-leaf total-glycoside capsule
  • Detecting method of rehmannia-leaf total-glycoside capsule
  • Detecting method of rehmannia-leaf total-glycoside capsule

Examples

Experimental program
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Effect test

Embodiment Construction

[0109] Detection method of local glucoside capsule preparation

[0110] [Prescription] Rehmannia glucosides 75g

[0111] [Preparation method] Take 75g of rehmannia glycosides fine powder (calculated as dry product), pulverize into fine powder, mix with starch, granulate, dry, add appropriate amount of micro-powder silica gel, fill into capsules, and make 1000 capsules, Instantly.

[0112] 【Properties】This product is a hard capsule, the content is light brown to tan granules and powder; slightly gas, slightly bitter taste.

[0113] 【identification】

[0114] (1) Take 40mg of the content of this product, grind it finely, add 5ml of methanol, shake to dissolve, filter, take 1ml of the filtrate, add 2-3 drops of 9% ferric chloride ethanol solution, and it will appear dark green;

[0115] (2) Take 20 mg of the content of this product, grind it finely, add 2 ml of methanol, shake to dissolve, filter, and use the filtrate as the test solution. Take another verbascoside reference s...

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Abstract

The invention discloses a detecting method of a rehmannia-leaf total-glycoside capsule, which comprises character, inspection, identification and content measurement items; and the identification is the component identification for rehmannia-leaf total glycoside and acteoside contained in the capsule, and the content measurement is a method for measuring the contents of the rehmannia-leaf total glycoside and the acteoside contained in the capsule. Aiming at no scientific and reasonable quality control detecting method for effectively controlling the product quality for the rehmannia-leaf total-glycoside capsule at present, on the basis of fully researching the rehmannia-leaf total glycoside of rehmannia-leaf extracts, the acteoside is determined as a detected component and a concrete and feasible component identification and content measurement method is established by combining with the preparation process of a medicament, and the adopted identification method has the advantages of strong specificity, high content measurement accuracy and good repeatability, thereby establishing the quality control standard of a rehmannia-leaf total-glycoside capsule preparation to effectively control the quality of the rehmannia-leaf total-glycoside capsule and ensuring the clinical curative effect and the safety of the medicament.

Description

technical field [0001] The invention relates to a method for detecting total glucosides of rehmannia phylloside capsules, belonging to the technical field of quality control of medicines. Background technique [0002] As a traditional Chinese medicinal material, Rehmannia glutinosa has been widely studied and applied in the field of medicine because it contains various types of pharmacological active ingredients, but there are few research reports on the chemical components of the aerial part of Rehmannia glutinosa. The inventors of the present application have studied the aerial part of rehmannia rehmanniae rehmanniae, and found that total glycosides of rehmannia rehmanniae with verbascoside as the main component has an immunosuppressive effect and a relatively high content in the chemical composition research and activity screening, so they developed The total glucosides of rehmannia glutinosa was extracted from rehmannia glutinosa leaves, and the national second-class new...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/48G01N30/90G01N21/78G01N30/02G01N21/33A61P13/12A61K127/00
Inventor 张孝齐边宝林杨健
Owner SICHUAN MEDCO PHARML
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