Method for preparing salinomycin particle premix

A salinomycin and premix technology, which is applied in the field of preparation of salinomycin granule premix, can solve the problems of salinomycin premix not meeting requirements, long production cycle, complicated process, etc., and achieve energy saving uniformity and stability, low oil content, the effect of ensuring stability

Active Publication Date: 2010-11-17
金河生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can adapt to market demand and prepare granular salinomycin sodium, the process is complicated and the production cycle is long, which is unfavorable to production cost and product quality.
In addition, the content of the salinomycin premix prepared by the prior art is usually 10% or 12%, and the high content of the salinomycin premix usually cannot meet the requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 content is the preparation method of the salinomycin granule premix of 16.5%

[0015] 1 Bacterial culture of salinomycin

[0016] Select a few single colonies with a plump appearance from the slant, and put the colony spores into 5ml sterile water and shake them evenly under aseptic conditions. Apply the spore suspension evenly on the spore-producing slant medium by streaking method and culture in a 30°C constant temperature room for 8 days. Mark the well-grown slant spore bottle with the strain number, the date of the next bottle, and store in a refrigerator at 2-4°C spare.

[0017] 2 Fermentation production

[0018] Add 30ml of water to each slant of the slant spores, scrape the spores carefully so that they do not carry any medium substances, put them together and pour them into a sterile bottle, and then inoculate them into a 500L first-level seed tank by the differential pressure method. After 30 hours, the mycelia Dense network segmented hyphae are...

Embodiment 2

[0025] Embodiment 2 content is the preparation method of the salinomycin granule premix of 31%

[0026] 1. Bacterial culture of salinomycin

[0027] Select a few single colonies with a plump appearance from the slant, and put the colony spores into 5ml sterile water and shake them evenly under aseptic conditions. Apply the spore suspension evenly on the spore-producing slant medium by streaking method and culture in a 30°C constant temperature room for 8 days. Mark the well-grown slant spore bottle with the strain number, the date of the next bottle, and store in a refrigerator at 2-4°C spare.

[0028] 2. Fermentation production

[0029] Add 30ml of water to each slant of the slant spores, scrape the spores carefully so that they do not carry any medium substances, put them together and pour them into a sterile bottle, and then inoculate them into a 500L first-level seed tank by the differential pressure method. After 32 hours, the mycelia Dense network segmented hyphae are...

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PUM

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Abstract

The invention relates to the veterinary drug field, in particular to a method for preparing salinomycin particle premix. The method comprises the concrete steps as follows: adjusting the pH value of salinomycin fermentation liquor with the valence of 60000-100000 mu / ml to be 6.5-10.0 by adopting alkali to obtain alkalic fermentation liquor; adding calcium carbonate with the addition amount of 0 to 25% by weight of the fermentation liquor to obtain salinomycin feed liquor; and spraying and drying the salinomycin feed liquor obtained in step a to obtain the salinomycin particle premix. The method can be used for preparing the salinomycin particle premix with high uniformity and stability by a rapid and energy-saving mode, and the content of the salinomycin particle premix can be up to 31%.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a preparation method of salinomycin granule premix. Background technique [0002] Salinomycin is a monocarboxylic acid polyether antibiotic specially used for animals. It has a strong inhibitory and killing effect on most Gram-positive bacteria and various coccidia. It is not easy to produce drug resistance and cross-resistance, and it is excreted quickly. The residual amount is extremely low, and it can be used to prevent and treat diarrhea, promote growth, and improve survival rate. Salinomycin has a cation transport function in cells, especially for potassium ions, sodium ions, and rubidium ions. It can make these ions selectively flow out of the membrane, causing ion balance damage, osmotic pressure imbalance, cell swelling, Deform, crack, disintegrate. [0003] The preparation method of the salinomycin premix includes a solvent extraction method, a spray drying method, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/351A61P31/04
Inventor 谢昌贤刘运添邓维康王鹏飞
Owner 金河生物科技股份有限公司
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