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Medicine compound containing candesartan cilexetil

A technology of candesartan cilexetil and composition, which is applied in the field of solid dispersion pharmaceutical composition, can solve problems such as the inability to solve the problem of candesartan cilexetil decomposition, increased production costs, poor stability, etc., and achieve improved stability , Inhibition of hydrolysis, complete dissolution effect

Active Publication Date: 2010-10-20
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The oral preparation of candesartan cilexetil was found to be less stable, and the technology of common preparations could not solve the problem of the decomposition of candesartan cilexetil during the preparation process and placement process
Maintain the stability of candesartan cilexetil by reducing the moisture in the preparation excipients to a relatively anhydrous state, and the increase in production costs is not easy to achieve

Method used

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  • Medicine compound containing candesartan cilexetil
  • Medicine compound containing candesartan cilexetil
  • Medicine compound containing candesartan cilexetil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014]

[0015] Preparation process: Weigh candesartan cilexetil, PEG6000 according to the prescription amount, and use hypromellose of polyvinylpyrrolidone to prepare a solid dispersion; take the above solid dispersion with lactose, microcrystalline cellulose, acesulfame potassium and colloid Silica mixed, 16 mesh wet granulation, drying at 60°C. Whole grains with 24 meshes, measure the moisture content, add magnesium stearate and acesulfame potassium, mix them, and compress into tablets at 60-80N.

Embodiment 2

[0017]

[0018] Preparation process: Weigh candesartan cilexetil, PEG6000, polyvinylpyrrolidone, and hypromellose to prepare a solid dispersion according to the prescription amount, and take the solid dispersion and lactose, croscarmellose sodium, and microcrystalline cellulose , acesulfame potassium and colloidal silicon dioxide, 16 mesh wet granulation, drying at 60°C. Whole grains with 24 meshes, measure the moisture content, add magnesium stearate and acesulfame potassium, mix them, and compress into tablets at 60-80N.

Embodiment 3

[0020]

[0021] Preparation process: Weigh candesartan fat, lactose, PEG6000, acesulfame potassium and colloidal silicon dioxide according to the prescription, mix, wet granulate with 16 mesh, and dry at 60°C. The granules are sized to 24 mesh, the moisture content is measured, magnesium stearate is added and mixed, and then pressed into tablets at 60-80N.

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Abstract

The invention discloses a medicine compound containing candesartan cilexetil, and a preparation method thereof; and the medicine compound improves the stability of the base medicine and improves the dissolution rate of the medicine by preparing solid dispersion. The medicine compound is used for curing primary hypertension.

Description

technical field [0001] The invention discloses a pharmaceutical composition containing candesartan cilexetil for treating essential hypertension, in particular to a pharmaceutical composition containing candesartan cilexetil solid dispersion. Background technique [0002] Candesartan cilexetil is a non-peptide angiotensin II receptor antagonist used in the treatment of essential hypertension. Because of its specificity and selectivity in increasing the level of angiotensin II receptors in the circulatory system and tissues, it has superior characteristics than angiotensin-converting enzyme (ACE) inhibitors, and does not increase the bradykinin induced by ACE enzymes. role, so it will not cause coughing side effects. [0003] Candesartan cilexetil was found to have poor stability in the study of oral preparations, and the technology of common preparations could not solve the problem of the decomposition of candesartan cilexetil during the preparation process and placement pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4184A61K47/38A61K47/34A61P9/12A61K47/10A61K47/32
Inventor 蔡巍
Owner AVENTIS PHARMA HAINAN
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