Sulfadiazine silver controlled-release gel and preparation method thereof
A technology of silver sulfadiazine and gel, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as pain, difficult quantitative control, short action time, etc., to achieve Control wound infection, promote healing, good moisturizing effect
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Embodiment 1
[0039] A kind of sulfadiazine silver controlled-release gel is made by following method:
[0040] (1) Under the condition of avoiding light, mix 0.001g of silver sulfadiazine and 20ml of 0.005g / ml sodium alginate aqueous solution to form a suspension, pour it on the glass plate mold, make its natural flow edge smooth, and avoid Under light conditions, freeze at -5°C for 5 hours, thaw at room temperature for 3 hours, and repeat freezing-thawing 5 times;
[0041] (2) get the water-soluble chitosan aqueous solution of 0.01g / ml of 100ml, add the calcium chloride of 1g, fully stir, make it dissolve, make water-soluble chitosan-calcium chloride mixed solution; Step (1 ) prepared product immersed in the water-soluble chitosan-calcium chloride mixed solution, placed for 10min, after removing the glass plate mold, rinsed 3 times with deionized water to obtain the silver sulfadiazine controlled-release gel.
[0042] The extract of the sulfadiazine silver controlled-release gel prepared...
Embodiment 2
[0044] A silver sulfadiazine controlled-release gel is characterized in that it is made by the following method:
[0045] (1) Under dark conditions, mix 0.1g of silver sulfadiazine and 20ml of 0.05g / ml sodium alginate aqueous solution into a suspension, and pour it on the glass plate mold to make its natural flow edge smooth. Under dark conditions, freeze at -20°C for 20 hours, thaw at room temperature for 7 hours, and repeat freezing-thawing 10 times;
[0046] (2) get the water-soluble chitosan aqueous solution of 0.005g / ml of 500ml, add the calcium chloride of 50g, fully stir, make it dissolve, make water-soluble chitosan-calcium chloride mixed solution; Step (1 ) The product prepared was immersed in the water-soluble chitosan-calcium chloride mixed solution, placed for 5min, and after removing the glass plate mold, rinsed 4 times with deionized water to obtain the silver sulfadiazine controlled-release gel.
[0047] The appearance of the silver sulfadiazine controlled-rele...
Embodiment 3
[0049] A silver sulfadiazine controlled-release gel is characterized in that it is made by the following method:
[0050] (1) Under the condition of avoiding light, mix 0.01g of silver sulfadiazine and 20ml of 0.01g / ml sodium alginate aqueous solution to form a suspension, pour it on the glass plate mold, make its natural flow edge smooth, and avoid Under light conditions, freeze at -10°C for 5 hours, thaw at room temperature for 1 hour, and repeat freezing-thawing 4 times;
[0051] (2) get the water-soluble chitosan aqueous solution of 0.05g / ml of 50ml, add the calcium chloride of 0.25g, fully stir, make it dissolve, make water-soluble chitosan-calcium chloride mixed solution; Step ( 1) The prepared product was submerged in the water-soluble chitosan-calcium chloride mixed solution, placed for 60 min, and after the glass plate mold was removed, rinsed 5 times with deionized water to obtain the silver sulfadiazine controlled-release gel.
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